Publications by authors named "John D Hulleman"

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Genetic removal of Nlrp3 protects against age-related and R345W Efemp1-induced basal laminar deposit formation.
Antonio J Ortega, Steffi Daniel, Marian Renwick, Pravallika Kambhampati, Krista N Thompson, John D Hulleman

Cell Death Dis· November 2025

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Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface.
John D Hulleman, Seungje Jeon, Sofia Bali, Sophia M DiCesare, Ali Abbas

ACS Chem Biol· August 2025

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A spectrum of cysteine mutations in fibulin-3 highlight its disulfide bonding complexity and potential to induce ER stress.
Gracen E Collier, Anna L Roovers, John D Hulleman

Sci Rep· August 2025

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Monitoring mutant myocilin secretion and localization in trabecular meshwork cell cultures using a protein complementation-based luminescence assay.
Hannah A Youngblood, Ethan F Harris, Kaylee P Lankford, Victoria Garfinkel, John D Hulleman

Exp Eye Res· June 2025

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Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface.
John D Hulleman, Seungje Jeon, Sofia Bali, Sophia M DiCesare, Ali Abbas

bioRxiv· May 2025

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Monitoring mutant myocilin secretion and localization in trabecular meshwork cell cultures using a protein complementation-based luminescence assay.
Hannah A Youngblood, Ethan F Harris, Kaylee P Lankford, Victoria Garfinkel, John D Hulleman

bioRxiv· March 2025

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RPE Basal Lamina Biology and Pathophysiology Related to Age-Related Macular Degeneration.
Steffi Daniel, Antonio J Ortega, John D Hulleman

Adv Exp Med Biol· February 2025

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Genetic removal of Nlrp3 protects against sporadic and R345W Efemp1-induced basal laminar deposit formation.
Antonio J Ortega, Steffi Daniel, Marian Renwick, Pravallika Kambhampati, Krista N Thompson, John D Hulleman

bioRxiv· October 2024

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Exploring ocular fibulin-3 (EFEMP1): Anatomical, age-related, and species perspectives.
Steffi Daniel, John D Hulleman

Biochim Biophys Acta Mol Basis Dis· August 2024

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GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology.
Sophia M DiCesare, Antonio J Ortega, Gracen E Collier, Steffi Daniel, Krista N Thompson, John D Hulleman

JCI Insight· August 2024

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A spectrum of clinically-identified cysteine mutations in fibulin-3 (EFEMP1) highlight its disulfide bonding complexity and potential to induce stress response activation.
Gracen E Collier, John D Hulleman

bioRxiv· July 2024

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Protocol for HiBiT tagging endogenous proteins using CRISPR-Cas9 gene editing.
Kaylee P Lankford, John D Hulleman

STAR Protoc· June 2024

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The Role of Vimentin in Human Corneal Fibroblast Spreading and Myofibroblast Transformation.
Miguel Miron-Mendoza, Kara Poole, Sophie DiCesare, Emi Nakahara, Meet Paresh Bhatt, John D Hulleman

Cells· June 2024

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E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration.
Yeshumenesh Zegeye, Bogale Aredo, Seher Yuksel, Dogan Can Kirman, Ashwani Kumar, John D Hulleman

Sci Rep· February 2024

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GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology.
Sophia M DiCesare, Antonio J Ortega, Gracen E Collier, Steffi Daniel, Krista N Thompson, John D Hulleman

bioRxiv· December 2023

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Ocular Amyloid, Condensates, and Aggregates - Higher-Order Protein Assemblies Participate in Both Retinal Degeneration and Function.
Michael H Hayes, DaNae R Woodard, John D Hulleman

Adv Exp Med Biol· July 2023

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Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis.
Seher Yuksel, Bogale Aredo, Yeshumenesh Zegeye, Cynthia X Zhao, Miao Tang, John D Hulleman

Commun Biol· May 2023

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A loss-of-function cysteine mutant in fibulin-3 (EFEMP1) forms aberrant extracellular disulfide-linked homodimers and alters extracellular matrix composition.
DaNae R Woodard, Steffi Daniel, Emi Nakahara, Ali Abbas, Sophia M DiCesare, John D Hulleman

Hum Mutat· December 2022

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Specifications of the ACMG/AMP variant curation guidelines for myocilin: Recommendations from the clingen glaucoma expert panel.
Kathryn P Burdon, Patricia Graham, Johanna Hadler, John D Hulleman, Francesca Pasutto

Hum Mutat· December 2022

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Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems.
Emi Nakahara, Vishruth Mullapudi, Gracen E Collier, Lukasz A Joachimiak, John D Hulleman

ACS Chem Biol· October 2022

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A Simple Secretion Assay for Assessing New and Existing Myocilin Variants.
Emi Nakahara, John D Hulleman

Curr Eye Res· June 2022

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Utility of the DHFR-based destabilizing domain across mouse models of retinal degeneration and aging.
Hui Peng, Prerana Ramadurgum, DaNae R Woodard, Steffi Daniel, Emi Nakahara, John D Hulleman

iScience· May 2022

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A novel homozygous missense mutation p.P388S in causes protein instability and retinitis pigmentosa.
DaNae R Woodard, Chao Xing, Pratyusha Ganne, Hanquan Liang, Avinash Mahindrakar, John D Hulleman

Mol Vis· November 2021

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A trimethoprim derivative impedes antibiotic resistance evolution.
Madhu Sudan Manna, Yusuf Talha Tamer, Ilona Gaszek, Nicole Poulides, Ayesha Ahmed, John D Hulleman

Nat Commun· May 2021

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Clinically-identified C-terminal mutations in fibulin-3 are prone to misfolding and destabilization.
DaNae R Woodard, Emi Nakahara, John D Hulleman

Sci Rep· February 2021

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