Publications by authors named "John D Isaacs"

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Skeletal muscle effects of Janus kinase inhibition in rheumatoid arthritis (RAMUS): a single-arm, experimental medicine study.
Joshua L Bennett, Kieren G Hollingsworth, Arthur G Pratt, Abbie E A Degnan, Gráinne S Gorman, John D Isaacs

Lancet Rheumatol· January 2026

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Early onset neutropenia in rituximab treated rheumatoid arthritis patients: a case series.
Chung Mun Alice Lin, Alice R Lorenzi, John D Isaacs, Faye A H Cooles

Rheumatol Adv Pract· September 2025

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Time-independent disease state identification defines distinct trajectories determined by localised vs systemic inflammation in patients with early rheumatoid arthritis.
Nils Steinz, Tjardo D Maarseveen, Erik B van den Akker, Andrew P Cope, John D Isaacs

Ann Rheum Dis· August 2025

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Pre-treatment GlycA measurement provides no additional predictive utility beyond routine clinical measures in patients with rheumatoid arthritis.
Stephanie F Ling, Chuan Fu Yap, Nisha Nair, Suzanne M M Verstappen, Ann W Morgan, John D Isaacs

Rheumatology (Oxford)· July 2025

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Endogenous Retroelement Activation is Implicated in Interferon-α Production and Anti-Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis.
Faye A H Cooles, Gemma Vidal Pedrola, Najib Naamane, Arthur G Pratt, Ben Barron-Millar, John D Isaacs

Arthritis Rheumatol· June 2025

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Bruton's tyrosine kinase - A new target for immune mediated inflammatory diseases?
John D Isaacs

Semin Arthritis Rheum· June 2025

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Chasing the target: reports from the Advances in Targeted Therapies meeting, 2024.
Kevin L Winthrop, Joan Bathon, Andreas Kerschbaumer, John D Isaacs, Philip Mease

Ann Rheum Dis· June 2025

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Comparative Effectiveness of Abatacept Versus Adalimumab in Shared Epitope Positive and Negative Patients With Rheumatoid Arthritis.
Chuan Fu Yap, Nisha Nair, Seema D Sharma, John Bowes, Amirah Binti Mohammad Ariff, John D Isaacs

Arthritis Rheumatol· June 2025

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Expert consensus statement on the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: 2024 update.
Peter Nash, Andreas Kerschbaumer, Victoria Konzett, Daniel Aletaha, Thomas Dörner, John D Isaacs

Ann Rheum Dis· May 2025

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Identifying Predictive Biomarkers of Response in Patients With Rheumatoid Arthritis Treated With Adalimumab Using Machine Learning Analysis of Whole-Blood Transcriptomics Data.
Chuan Fu Yap, Nisha Nair, Ann W Morgan, John D Isaacs, Anthony G Wilson

Arthritis Rheumatol· May 2025

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Patient-reported outcomes as early warning signs of flare following drug cessation in rheumatoid arthritis.
Leher Gumber, Fiona Rayner, Theophile Bigirumurame, Bernard Dyke, Andrew Melville, John D Isaacs

RMD Open· April 2025

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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trials.
Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, John D Isaacs

EClinicalMedicine· January 2025

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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocols.
Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, John D Isaacs

EClinicalMedicine· January 2025

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Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis.
Lucy MacDonald, Aziza Elmesmari, Domenico Somma, Jack Frew, Clara Di Mario, John D Isaacs

Immunity· December 2024

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Micro-RNA content of circulating extracellular vesicles in early rheumatoid arthritis as biomarkers and mediators of methotrexate efficacy.
Daniel Maunder, Philip M Brown, Ben Barron-Millar, Dennis W Lendrem, Najib Naamane, John D Isaacs

Rheumatology (Oxford)· August 2024

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Monitoring immunE DysregulAtion foLLowing Immune checkpOint-inhibitioN (MEDALLION): protocol for an observational cancer immunotherapy cohort study.
Abigail Gault, Linda Hogarth, Kristian C Williams, Alastair Greystoke, Neil Rajan, John D Isaacs

BMC Cancer· June 2024

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Population Pharmacokinetic Analysis and Simulation of Alternative Dosing Regimens for Biosimilars to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis.
Stephanie F Ling, Kayode Ogungbenro, Adam S Darwich, Amirah Binti Mohammad Ariff, Nisha Nair, John D Isaacs

Pharmaceutics· May 2024

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Operational complexities in international clinical trials: a systematic review of challenges and proposed solutions.
Leher Gumber, Opeyemi Agbeleye, Alex Inskip, Ross Fairbairn, Madeleine Still, John D Isaacs

BMJ Open· April 2024

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Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2023.
Kevin L Winthrop, Philip Mease, Andreas Kerschbaumer, Reinhard E Voll, Ferdinand C Breedveld, John D Isaacs

Ann Rheum Dis· March 2024

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Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial.
Andrew P Cope, Marianna Jasenecova, Joana C Vasconcelos, Andrew Filer, Karim Raza, John D Isaacs

Lancet· March 2024

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Role of IFN-α in Rheumatoid Arthritis.
Chung M A Lin, John D Isaacs, Faye A H Cooles

Curr Rheumatol Rep· February 2024

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Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission.
Kenneth F Baker, David McDonald, Gillian Hulme, Rafiqul Hussain, Jonathan Coxhead, John D Isaacs

Nat Commun· February 2024

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Adenosine metabolic signature in circulating CD4+ T cells predicts remission in rheumatoid arthritis.
Philip M Brown, Amy E Anderson, Najib Naamane, Dennis W Lendrem, Ann W Morgan, John D Isaacs

RMD Open· February 2024

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CAR T Cells - A New Horizon for Autoimmunity?
John D Isaacs

N Engl J Med· February 2024

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