Publications by authors named "John D Klement"

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STAT5 Activation Enhances Adoptive Therapy Combined with Peptide Vaccination by Preventing PD-1 Inhibition.
Aaron E Fan, Hussein Sultan, Takumi Kumai, Valentyna I Fesenkova, Juan Wu, John D Klement

Mol Cancer Ther· March 2025

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PD-L1 restrains PD-1Nrp1 Treg cells to suppress inflammation-driven colorectal tumorigenesis.
Dakota B Poschel, John D Klement, Alyssa D Merting, Chunwan Lu, Yang Zhao

Cell Rep· October 2024

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In vitro antibody-mediated SARS-CoV-2 infection suppression through human ACE2 receptor blockade.
Priscilla S Redd, Alyssa D Merting, John D Klement, Dakota B Poschel, Dafeng Yang

Immunol Lett· August 2024

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Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment.
John D Klement, Priscilla S Redd, Chunwan Lu, Alyssa D Merting, Dakota B Poschel

Cancer Cell· March 2023

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IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes.
Dakota B Poschel, Mercy Kehinde-Ige, John D Klement, Dafeng Yang, Alyssa D Merting

Cells· January 2023

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Lipid Nanoparticle Delivery of Fas Plasmid Restores Fas Expression to Suppress Melanoma Growth .
Zeinab Y Al Subeh, Dakota B Poschel, Priscilla S Redd, John D Klement, Alyssa D Merting

ACS Nano· August 2022

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H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth.
Chunwan Lu, Dafeng Yang, John D Klement, Yolonda L Colson, Nicholas H Oberlies

Oncogene· April 2022

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G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes.
Chunwan Lu, Dafeng Yang, John D Klement, Yolonda L Colson, Nicholas H Oberlies

J Immunother Cancer· January 2022

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Restoring FAS Expression via Lipid-Encapsulated FAS DNA Nanoparticle Delivery Is Sufficient to Suppress Colon Tumor Growth In Vivo.
Alyssa D Merting, Dakota B Poschel, Chunwan Lu, John D Klement, Dafeng Yang

Cancers (Basel)· January 2022

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Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells.
Maria Y Liu, John D Klement, Candace J Langan, Jan van Riggelen, Kebin Liu

Cell Immunol· August 2021

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WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape.
Chunwan Lu, Zhuoqi Liu, John D Klement, Dafeng Yang, Alyssa D Merting

J Immunother Cancer· July 2021

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Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
Huabin Zhu, John D Klement, Chunwan Lu, Priscilla S Redd, Dafeng Yang

J Immunol· March 2021

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MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment.
T William Mudd, Chunwan Lu, John D Klement, Kebin Liu

Cell Immunol· February 2021

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Osteopontin Blockade Immunotherapy Increases Cytotoxic T Lymphocyte Lytic Activity and Suppresses Colon Tumor Progression.
John D Klement, Dakota B Poschel, Chunwan Lu, Alyssa D Merting, Dafeng Yang

Cancers (Basel)· February 2021

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Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells.
Mohammed L Ibrahim, Chunwan Lu, John D Klement, Priscilla S Redd, Dafeng Yang

Cancer Immunol Immunother· November 2020

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Osteopontin: A Key Regulator of Tumor Progression and Immunomodulation.
Hannah R Moorman, Dakota Poschel, John D Klement, Chunwan Lu, Priscilla S Redd

Cancers (Basel)· November 2020

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p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy.
Chunwan Lu, John D Klement, Alyssa D Smith, Dafeng Yang, Jennifer L Waller

J Immunother Cancer· October 2020

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Autocrine IL6-Mediated Activation of the STAT3-DNMT Axis Silences the TNFα-RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells.
Alyssa D Smith, Chunwan Lu, Daniela Payne, Amy V Paschall, John D Klement

Cancer Res· August 2020

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SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth.
Chunwan Lu, John D Klement, Dafeng Yang, Thomas Albers, Iryna O Lebedyeva

Cancer Lett· April 2020

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Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes.
Chunwan Lu, John D Klement, Mohammed L Ibrahim, Wei Xiao, Priscilla S Redd

J Immunother Cancer· June 2019

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SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion.
Chunwan Lu, Dafeng Yang, John D Klement, Il Kyu Oh, Natasha M Savage

Cancer Immunol Res· March 2019

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Loss of Fas Expression and Function Is Coupled with Colon Cancer Resistance to Immune Checkpoint Inhibitor Immunotherapy.
Wei Xiao, Mohammed L Ibrahim, Priscilla S Redd, John D Klement, Chunwan Lu

Mol Cancer Res· February 2019

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An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion.
John D Klement, Amy V Paschall, Priscilla S Redd, Mohammed L Ibrahim, Chunwan Lu

J Clin Invest· December 2018

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Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.
Mohammed L Ibrahim, John D Klement, Chunwan Lu, Priscilla S Redd, Wei Xiao

Cell Rep· December 2018

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H3K4me3 mediates the NF-κB p50 homodimer binding to the promoter to activate PD-1 transcription in T cells.
Priscilla S Redd, Chunwan Lu, John D Klement, Mohammed L Ibrahim, Gang Zhou

Oncoimmunology· July 2018

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