Publications by authors named "John K Botson"

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Safety, Tolerability, and Efficacy of Shorter Infusion Durations of Pegloticase Administered to Patients With Uncontrolled Gout Receiving Methotrexate: AGILE Trial.
Orrin M Troum, John K Botson, Fang Fang, Afroz S Mohammad, Supra Verma

J Clin Rheumatol· January 2026

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Monosodium Urate Crystal Depletion and Bone Erosion Response in Kidney Transplant Recipients With Uncontrolled Gout Treated With Pegloticase: PROTECT Serial Dual-Energy Computed Tomography Findings.
Nicola Dalbeth, Abdul Abdellatif, John K Botson, Kenneth G Saag, Ada Kumar

Transplant Direct· June 2025

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Pegloticase and Methotrexate Cotherapy in Patients With Uncontrolled Gout With Prior Pegloticase Monotherapy Failure: Findings of an Open-Label Trial.
Orrin M Troum, John K Botson, Katie Obermeyer, Bo Chao, Yang Song

ACR Open Rheumatol· January 2025

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Controversies and practical management of patients with gout and chronic kidney disease.
Richard J Johnson, Brian F Mandell, Naomi Schlesinger, David B Mount, John K Botson

Kidney Int· October 2024

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A Randomized, Double-Blind, Placebo-Controlled Multicenter Efficacy and Safety Study of Methotrexate to Increase Response Rates in Patients With Uncontrolled Gout Receiving Pegloticase: 12-Month Findings.
John K Botson, Kenneth Saag, Jeff Peterson, Katie Obermeyer, Yan Xin

ACR Open Rheumatol· August 2023

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A Randomized, Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled Gout Receiving Pegloticase: Primary Efficacy and Safety Findings.
John K Botson, Kenneth Saag, Jeff Peterson, Naval Parikh, Stephen Ong

Arthritis Rheumatol· February 2023

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Improved joint and patient-reported health assessments with pegloticase plus methotrexate co-therapy in patients with uncontrolled gout: 12-month exploratory outcomes of the MIRROR open-label trial.
John K Botson, Katie Obermeyer, Brian LaMoreaux, Lin Zhao, Michael E Weinblatt

Arthritis Res Ther· December 2022

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Dual-energy CT assessment of rapid monosodium urate depletion and bone erosion remodelling during pegloticase plus methotrexate co-therapy.
Nicola Dalbeth, Fabio Becce, John K Botson, Lin Zhao, Ada Kumar

Rheumatology (Oxford)· November 2022

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A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study.
John K Botson, John R P Tesser, Ralph Bennett, Howard M Kenney, Paul M Peloso

Arthritis Res Ther· August 2022

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Pretreatment and Coadministration With Methotrexate Improved Durability of Pegloticase Response: An Observational, Proof-of-Concept Case Series.
John K Botson, Jeff Peterson

J Clin Rheumatol· January 2022

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Expert Opinion on Pegloticase with Concomitant Immunomodulatory Therapy in the Treatment of Uncontrolled Gout to Improve Efficacy, Safety, and Durability of Response.
John K Botson, Herbert S B Baraf, Robert T Keenan, John Albert, Karim R Masri

Curr Rheumatol Rep· January 2022

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Pegloticase in Combination With Methotrexate in Patients With Uncontrolled Gout: A Multicenter, Open-label Study (MIRROR).
John K Botson, John R P Tesser, Ralph Bennett, Howard M Kenney, Paul M Peloso

J Rheumatol· May 2021

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The effect of immunomodulators on the efficacy and tolerability of pegloticase: a systematic review.
Robert T Keenan, John K Botson, Karim R Masri, Lissa Padnick-Silver, Brian LaMoreaux

Semin Arthritis Rheum· April 2021

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Pegloticase hypersensitivity desensitisation: an outpatient, 3-bag, 12-step protocol.
John K Botson

BMJ Case Rep· June 2020

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