Publications by authors named "John L Spudich"

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Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics.
Elena G Govorunova, Oleg A Sineshchekov, Hai Li, Yueyang Gou, Hongmei Chen, John L Spudich

Elife· September 2025

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Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics.
Elena G Govorunova, Oleg A Sineshchekov, Hai Li, Yueyang Gou, Hongmei Chen, John L Spudich

bioRxiv· July 2025

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Structural insights into light-gating of potassium-selective channelrhodopsin.
Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Probal Nag, Tal Dogon, John L Spudich

Nat Commun· February 2025

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Channel Gating in Kalium Channelrhodopsin Slow Mutants.
Oleg A Sineshchekov, Elena G Govorunova, Hai Li, Yumei Wang, John L Spudich

J Mol Biol· March 2024

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Isospectral intermediates in the photochemical reaction cycle of anion channelrhodopsin GtACR1.
Pamela Schleissner, Istvan Szundi, Eefei Chen, Hai Li, John L Spudich

Biophys J· October 2023

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Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K and Na selectivities.
Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Elena G Govorunova, Oleg A Sineshchekov, John L Spudich

Nat Commun· July 2023

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Sequential absorption of two photons creates a bistable form of RubyACR responsible for its strong desensitization.
Oleg A Sineshchekov, Elena G Govorunova, Hai Li, Yumei Wang, John L Spudich

Proc Natl Acad Sci U S A· May 2023

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Potassium-selective channelrhodopsins.
Elena G Govorunova, Oleg A Sineshchekov, John L Spudich

Biophys Physicobiol· March 2023

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Structural Foundations of Potassium Selectivity in Channelrhodopsins.
Elena G Govorunova, Oleg A Sineshchekov, Leonid S Brown, Ana-Nicoleta Bondar, John L Spudich

mBio· December 2022

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Biophysical characterization of light-gated ion channels using planar automated patch clamp.
Elena G Govorunova, Oleg A Sineshchekov, Leonid S Brown, John L Spudich

Front Mol Neurosci· August 2022

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Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition.
Elena G Govorunova, Yueyang Gou, Oleg A Sineshchekov, Hai Li, Xiaoyu Lu, John L Spudich

Nat Neurosci· July 2022

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Emerging Diversity of Channelrhodopsins and Their Structure-Function Relationships.
Elena G Govorunova, Oleg A Sineshchekov, John L Spudich

Front Cell Neurosci· January 2022

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Heterogeneous side effects of cortical inactivation in behaving animals.
Ariana R Andrei, Samantha Debes, Mircea Chelaru, Xiaoqin Liu, Elsa Rodarte, John L Spudich

Elife· September 2021

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Cation and Anion Channelrhodopsins: Sequence Motifs and Taxonomic Distribution.
Elena G Govorunova, Oleg A Sineshchekov, Hai Li, Yumei Wang, Leonid S Brown, John L Spudich

mBio· August 2021

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The crystal structure of bromide-bound ACR1 reveals a pre-activated state in the transmembrane anion tunnel.
Hai Li, Chia-Ying Huang, Elena G Govorunova, Oleg A Sineshchekov, Adrian Yi, John L Spudich

Elife· May 2021

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Probing Channelrhodopsin Electrical Activity in Algal Cell Populations.
Oleg A Sineshchekov, Elena G Govorunova, John L Spudich

Methods Mol Biol· March 2021

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An Open Resource for Non-human Primate Optogenetics.
Sébastien Tremblay, Leah Acker, Arash Afraz, Daniel L Albaugh, Hidetoshi Amita, John L Spudich

Neuron· December 2020

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RubyACRs, nonalgal anion channelrhodopsins with highly red-shifted absorption.
Elena G Govorunova, Oleg A Sineshchekov, Hai Li, Yumei Wang, Leonid S Brown, John L Spudich

Proc Natl Acad Sci U S A· September 2020

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Conductance Mechanisms of Rapidly Desensitizing Cation Channelrhodopsins from Cryptophyte Algae.
Oleg A Sineshchekov, Elena G Govorunova, Hai Li, Yumei Wang, Michael Melkonian, John L Spudich

mBio· April 2020

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Opposite Charge Movements Within the Photoactive Site Modulate Two-Step Channel Closing in GtACR1.
Oleg A Sineshchekov, Elena G Govorunova, Hai Li, Xin Wang, John L Spudich

Biophys J· November 2019

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Extending the Time Domain of Neuronal Silencing with Cryptophyte Anion Channelrhodopsins.
Elena G Govorunova, Oleg A Sineshchekov, Raheleh Hemmati, Roger Janz, Olivier Morelle, John L Spudich

eNeuro· January 2019

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Crystal structure of a natural light-gated anion channelrhodopsin.
Hai Li, Chia-Ying Huang, Elena G Govorunova, Christopher T Schafer, Oleg A Sineshchekov, John L Spudich

Elife· January 2019

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Rhodopsin optogenetic toolbox v2.0 for light-sensitive excitation and inhibition in Caenorhabditis elegans.
Amelie Bergs, Christian Schultheis, Elisabeth Fischer, Satoshi P Tsunoda, Karen Erbguth, John L Spudich

PLoS One· March 2018

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Bacteriorhodopsin-like channelrhodopsins: Alternative mechanism for control of cation conductance.
Oleg A Sineshchekov, Elena G Govorunova, Hai Li, John L Spudich

Proc Natl Acad Sci U S A· November 2017

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Structural Changes in an Anion Channelrhodopsin: Formation of the K and L Intermediates at 80 K.
Adrian Yi, Hai Li, Natalia Mamaeva, Roberto E Fernandez De Cordoba, Johan Lugtenburg, John L Spudich

Biochemistry· April 2017

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