Publications by authors named "John Lear"

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Recurrent morphoeic basal cell carcinoma with metastatic progression in a 34-year-old patient: a case report.
Usamah M Afzal, Faisal R Ali, Deemesh Oudit, Roxana Totorean, Patrick Shenjere, John T Lear

Clin Exp Dermatol· May 2025

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Melanoma: assessment and management summary of the 2022 update of the National Institute for Health and Care Excellence guidelines.
Myles J Smith, Howard Peach, Steve Keohane, John Lear, Lynne A Jamieson

Br J Dermatol· April 2025

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Topical application of the Hedgehog inhibitor patidegib in patients with Gorlin syndrome: a phase II trial.
John T Lear, Catherine A Harwood, Zeeshaan Hasan, Jonathan Kentley, Jason Thomson

Br J Dermatol· March 2025

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Metastatic basal cell carcinomas in Gorlin syndrome-A case series and literature review.
Usamah M Afzal, Faisal R Ali, Deemesh Oudit, Roxana Totorean, Gareth Evans, John T Lear

Australas J Dermatol· February 2025

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Topical sirolimus in dermatology: a systematic review.
Usamah M Afzal, Mohammad Alazemi, Omar Ali, Faisal R Ali, John T Lear

Clin Exp Dermatol· December 2024

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The "Personalising Actinic Keratosis Treatment for Immunocompromised Patients" (IM-PAKT) Project: An Expert Panel Opinion.
Rolf-Markus Szeimies, Claas Ulrich, Carla Ferrándiz-Pulido, Gunther F L Hofbauer, John Thomas Lear

Dermatol Ther (Heidelb)· July 2024

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Pharmacokinetics and pharmacodynamics of Hedgehog pathway inhibitors used in the treatment of advanced or treatment-refractory basal cell carcinoma.
John T Lear, Linda M Morris, Dylan B Ness, Lionel D Lewis

Expert Rev Clin Pharmacol· December 2023

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Concomitant medication use does not appear to alter long-term efficacy of sonidegib for advanced basal cell carcinoma: a post hoc analysis based on the 42-month BOLT study.
John T Lear, Caroline Robert, Jean-Jacques Grob, Reinhard Dummer, Alexander Guminski

Eur J Dermatol· June 2023

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Germline intergenic duplications at Xq26.1 underlie Bazex-Dupré-Christol basal cell carcinoma susceptibility syndrome.
Yanshan Liu, Siddharth Banka, Yingzhi Huang, Jonathan Hardman-Smart, Derek Pye, John T Lear

Br J Dermatol· December 2022

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Clinicopathological characteristics of individuals with coexisting melanoma and chronic lymphocytic leukaemia: a multicentre cohort study.
Rachel Mary Fisher, Antonio Ji-Xu, Rachel Abbott, Tanya Basu, Alistair Brown, John T Lear

Clin Exp Dermatol· November 2022

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Topical treatment of actinic keratoses in organ transplant recipients: a feasibility study for SPOT (Squamous cell carcinoma Prevention in Organ transplant recipients using Topical treatments).
Zeeshaan-Ul Hasan, Ikhlaaq Ahmed, Rubeta N Matin, Victoria Homer, John T Lear

Br J Dermatol· September 2022

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A Real-World Data Study on the Healthcare Resource Use for Uncontrolled Moderate-to-Severe Atopic Dermatitis in Secondary Care in the United Kingdom Prior to the Introduction of Biologic Treatment.
Richard D A Hudson, Mahreen Ameen, Susannah M C George, Catherine A Harwood, Richard B Weller, John T Lear

Clinicoecon Outcomes Res· April 2022

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Comparison of ALitretinoin with PUVA as the first-line treatment in patients with severe chronic HAnd eczema (ALPHA): study protocol for a randomised controlled trial.
Isabelle L Smith, Rachael Gilberts, Sarah Brown, Catherine Fernandez, Jane Nixon, John T Lear

BMJ Open· February 2022

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Using drug scheduling to manage adverse events associated with hedgehog pathway inhibitors for basal cell carcinoma.
John T Lear, Reinhard Dummer, Alexander Guminski

Oncotarget· December 2021

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Female Immunity Protects from Cutaneous Squamous Cell Carcinoma.
Timothy Budden, Caroline Gaudy-Marqueste, Sarah Craig, Yuan Hu, Charles H Earnshaw, John Lear

Clin Cancer Res· June 2021

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Efficacy of sonidegib in histologic subtypes of advanced basal cell carcinoma: Results from the final analysis of the randomized phase 2 Basal Cell Carcinoma Outcomes With LDE225 Treatment (BOLT) trial at 42 months.
Reinhard Dummer, John T Lear, Alex Guminski, Liang Joo Leow, Nicholas Squittieri

J Am Acad Dermatol· April 2021

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Expression of Glioma-associated oncogene homolog 1 as biomarker with sonidegib in advanced basal cell carcinoma.
Reinhard Dummer, Li Liu, Nicholas Squittieri, Ralf Gutzmer, John Lear

Oncotarget· September 2020

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Efficacy and Safety of Sonidegib in Adult Patients with Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome): Results from a Phase 2, Double-Blind, Randomized Trial.
John T Lear, Axel Hauschild, Eggert Stockfleth, Nicholas Squittieri, Nicole Basset-Seguin

Clin Cosmet Investig Dermatol· February 2020

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Photodynamic therapy corrects abnormal cancer-associated gene expression observed in actinic keratosis lesions and induces a remodeling effect in photodamaged skin.
Florence Joly, Sophie Deret, Bastien Gamboa, Corinne Menigot, Paul Fogel, John Lear

J Dermatol Sci· May 2018

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Emerging trends in the treatment of advanced basal cell carcinoma.
Michael R Migden, Anne Lynn S Chang, Luc Dirix, Alexander J Stratigos, John T Lear

Cancer Treat Rev· March 2018

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A Novel Actinic Keratosis Field Assessment Scale for Grading Actinic Keratosis Disease Severity.
Brigitte Dréno, Rino Cerio, Thomas Dirschka, Ignasi Figueras Nart, John T Lear

Acta Derm Venereol· October 2017

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Actinic Keratosis, a Chronic, Progressive Disease: Understanding Clinical Gaps to Optimise Patient Management.
Rino Cerio, Thomas Dirschka, Brigitte Dréno, Ignasi Figueras Nart, John T Lear

Acta Derm Venereol· August 2017

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First evidence of genotype-phenotype correlations in Gorlin syndrome.
D Gareth Evans, Deemesh Oudit, Miriam J Smith, David Rutkowski, Ernest Allan, John T Lear

J Med Genet· August 2017

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Treatment patterns and outcomes for patients with locally advanced basal cell carcinoma before availability of Hedgehog pathway inhibitors: a retrospective chart review.
John T Lear, Nicole Basset-Seguin, Martin Kaatz, Thomas Jouary, Laurent Mortier

Eur J Dermatol· August 2017

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Vismodegib for Locally Advanced Periocular and Orbital Basal Cell Carcinoma: A Review of 15 Consecutive Cases.
Kai Yuen Wong, Kate Fife, John T Lear, Richard D Price, Amer J Durrani

Plast Reconstr Surg Glob Open· July 2017

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