Publications by authors named "John McIntosh"

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Profiling of Diverse Pyridoxal-5'-Phosphate Dependent Enzymes Reveals Promiscuous Aldolase Activity with (2-Azaaryl)methanamines.
Kendrick L Smith, Madeline A Arbuckle, Alexander T Kim, Chun-Yi Tsai, John A McIntosh

J Am Chem Soc· July 2025

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Decarboxylation in Natural Products Biosynthesis.
Nguyet A Nguyen, Jacob H Forstater, John A McIntosh

JACS Au· August 2024

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Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.
Wai Ling Cheung-Lee, Joshua N Kolev, John A McIntosh, Agnieszka A Gil, Weilan Pan

Angew Chem Int Ed Engl· March 2024

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Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454.
Tamas Benkovics, Feng Peng, Eric M Phillips, Chihui An, Rachel S Bade, John A McIntosh

J Am Chem Soc· April 2022

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A kinase-cGAS cascade to synthesize a therapeutic STING activator.
John A McIntosh, Zhijian Liu, Brian M Andresen, Nastaran Salehi Marzijarani, Jeffrey C Moore

Nature· March 2022

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Quantitation and speciation of residual protein within active pharmaceutical ingredients using image analysis with SDS-PAGE.
Joseph P Smith, Nicole M Ralbovsky, Mackenzie L Lauro, Erik Hoyt, Erik D Guetschow, John A McIntosh

J Pharm Biomed Anal· January 2022

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Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19.
John A McIntosh, Tamas Benkovics, Steven M Silverman, Mark A Huffman, Jongrock Kong

ACS Cent Sci· December 2021

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HEED: NYU's Mentor-Protégé Model of Dental Education.
Charles N Bertolami, Elyse Bloom, John D McIntosh

Compend Contin Educ Dent· February 2021

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Deep Dive into Machine Learning Models for Protein Engineering.
Yuting Xu, Deeptak Verma, Robert P Sheridan, Andy Liaw, Junshui Ma, John McIntosh

J Chem Inf Model· June 2020

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Hemoprotein-Catalyzed Cyclopropanation En Route to the Chiral Cyclopropanol Fragment of Grazoprevir.
Taejin Kim, Amude M Kassim, Ajit Botejue, Chen Zhang, Jared Forte, John A McIntosh

Chembiochem· May 2019

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Molecular basis for the broad substrate selectivity of a peptide prenyltransferase.
Yue Hao, Elizabeth Pierce, Daniel Roe, Maho Morita, John A McIntosh

Proc Natl Acad Sci U S A· December 2016

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Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor.
Kari E Hernandez, Hans Renata, Russell D Lewis, S B Jennifer Kan, Chen Zhang, John A McIntosh

ACS Catal· November 2016

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Metabolic model for diversity-generating biosynthesis.
Ma Diarey Tianero, Elizabeth Pierce, Shrinivasan Raghuraman, Debosmita Sardar, John A McIntosh

Proc Natl Acad Sci U S A· February 2016

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Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450.
John A McIntosh, Thomas Heel, Andrew R Buller, Linda Chio, Frances H Arnold

J Am Chem Soc· November 2015

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Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450.
Christopher C Farwell, Ruijie K Zhang, John A McIntosh, Todd K Hyster, Frances H Arnold

ACS Cent Sci· May 2015

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