Publications by authors named "John Parrington"

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Added value of abdominal CT after treatment of lung cancer.
Yunjing Zhu, Jing Liu, Kai Nie, Qunhui Chen, Lingming Yu, John Parrington

Quant Imaging Med Surg· August 2025

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TPC2 in drug development: Emerging target for cancer, viral infections, cardiovascular diseases, and neurological disorders.
Abeer F Alharbi, John Parrington

Pharmacol Res· March 2025

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TPC1 regulates melanoma tumourigenesis via mTORC1 and TFEB.
Xuhui Jin, Ali A Hanbashi, Faroq Kamli, Xiaoqi Pan, Colin R Goding, John Parrington

Heliyon· November 2024

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Endolysosomal two-pore channel 2 plays opposing roles in primary and metastatic malignant melanoma cells.
Samantha Barbonari, Antonella D'Amore, Ali A Hanbashi, Fioretta Palombi, Anna Riccioli, John Parrington

Cell Biol Int· April 2024

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Whole-exome sequencing identifies cancer-associated variants of the endo-lysosomal ion transport channels in the Saudi population.
Lama Binobaid, Homood M As Sobeai, Khalid Alhazzani, Lama AlAbdi, Meshari M Alwazae, John Parrington

Saudi Pharm J· March 2024

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Development of a nomogram based on the clinicopathological and CT features to predict the survival of primary pulmonary lymphoepithelial carcinoma patients.
Kai Nie, Lin Zhu, Yuxuan Zhang, Yinan Chen, John Parrington

Respir Res· March 2024

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Loss of two-pore channel 2 function in melanoma-derived tumours reduces tumour growth in vivo but greatly increases tumour-related toxicity in the organism.
Ali Hanbashi, Moureq Alotaibi, Homood M As Sobeai, Lama Binobaid, Khalid Alhazzani, John Parrington

Cancer Cell Int· December 2023

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Clinicopathological features and survival of rare primary pulmonary lymphoepithelial carcinoma: A cohort from a single center.
Kai Nie, GuangYu Tao, Lin Zhu, Yuxuan Zhang, Ruiying Zhao, John Parrington

J Surg Oncol· September 2023

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Relevance of lysosomal Ca signalling machinery in cancer.
Samantha Barbonari, Antonella D'Amore, Fioretta Palombi, Paola De Cesaris, John Parrington

Cell Calcium· March 2022

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Effect of Aphidicolin, a Reversible Inhibitor of Eukaryotic Nuclear DNA Replication, on the Production of Genetically Modified Porcine Embryos by CRISPR/Cas9.
Sergio Navarro-Serna, Celia Piñeiro-Silva, Chiara Luongo, John Parrington, Raquel Romar

Int J Mol Sci· February 2022

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Deciphering the Role of Endolysosomal Ca Channels in Immunity.
Abeer F Alharbi, John Parrington

Front Immunol· September 2021

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TPC2 targeting evolution: Leveraging therapeutic opportunities for cancer.
Abeer F Alharbi, John Parrington

Cell Chem Biol· August 2021

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The role of genetic polymorphisms in endolysosomal ion channels TPC2 and P2RX4 in cancer pathogenesis, prognosis, and diagnosis: a genetic association in the UK Biobank.
Abeer F Alharbi, John Parrington

NPJ Genom Med· July 2021

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A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK.
Yuxuan Zhang, Chen Gong, Dawei Li, Zhi-Wei Wang, Shengda D Pu, John Parrington

Sci Rep· April 2021

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Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination.
Sergio Navarro-Serna, Alaa Hachem, Analuce Canha-Gouveia, Ali Hanbashi, Gabriela Garrappa, John Parrington

CRISPR J· February 2021

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Deciphering the Role of Ca Signalling in Cancer Metastasis: From the Bench to the Bedside.
Abeer Alharbi, Yuxuan Zhang, John Parrington

Cancers (Basel)· January 2021

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Targeting Two-Pore Channels: Current Progress and Future Challenges.
Xuhui Jin, Yuxuan Zhang, Abeer Alharbi, Ali Hanbashi, Ali Alhoshani, John Parrington

Trends Pharmacol Sci· August 2020

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Loss of Two-Pore Channel 2 (TPC2) Expression Increases the Metastatic Traits of Melanoma Cells by a Mechanism Involving the Hippo Signalling Pathway and Store-Operated Calcium Entry.
Antonella D'Amore, Ali Ahmed Hanbashi, Silvia Di Agostino, Fioretta Palombi, Andrea Sacconi, John Parrington

Cancers (Basel)· August 2020

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Endolysosomal Ca Signaling in Cancer: The Role of TPC2, From Tumorigenesis to Metastasis.
Abeer F Alharbi, John Parrington

Front Cell Dev Biol· December 2019

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The eggstraordinary story of how life begins.
John Parrington, Christophe Arnoult, Rafael A Fissore

Mol Reprod Dev· January 2019

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Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain.
Hong He, Katie Holl, Sarah DeBehnke, Chay Teng Yeo, Polly Hansen, John Parrington

Physiol Genomics· August 2018

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Synthesis of the Ca-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling.
Wee K Lin, Emma L Bolton, Wilian A Cortopassi, Yanwen Wang, Fiona O'Brien, John Parrington

J Biol Chem· August 2017

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PLCζ is the physiological trigger of the Ca oscillations that induce embryogenesis in mammals but conception can occur in its absence.
Alaa Hachem, Jonathan Godwin, Margarida Ruas, Hoi Chang Lee, Minerva Ferrer Buitrago, John Parrington

Development· August 2017

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Ca release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos.
Jeffrey J Kelu, Sarah E Webb, John Parrington, Antony Galione, Andrew L Miller

Dev Biol· May 2017

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Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.
Vanessa Garcia-Rua, Sandra Feijoo-Bandin, Maria Garcia-Vence, Alana Aragon-Herrera, Susana B Bravo, John Parrington

J Biosci· December 2016

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