Publications by authors named "John R Toomey"

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High FGF23 Levels Failed to Predict Cardiac Hypertrophy in Animal Models of Hyperphosphatemia and Chronic Renal Failure.
Ian Moench, Karpagam Aravindhan, Joanne Kuziw, Christine G Schnackenberg, Robert N Willette, John R Toomey

J Endocr Soc· August 2021

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Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype.
Christine Y Ivashchenko, Gordon C Pipes, Irina M Lozinskaya, Zuojun Lin, Xu Xiaoping, John R Toomey

Am J Physiol Heart Circ Physiol· September 2013

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An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.
Kevin S Thorneloe, Mui Cheung, Weike Bao, Hasan Alsaid, Stephen Lenhard, John R Toomey

Sci Transl Med· November 2012

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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs.
Robert J Young, Carl Adams, Mike Blows, David Brown, Cynthia L Burns-Kurtis, John R Toomey

Bioorg Med Chem Lett· March 2011

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The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs.
Nigel S Watson, Carl Adams, David Belton, David Brown, Cynthia L Burns-Kurtis, John R Toomey

Bioorg Med Chem Lett· March 2011

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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs.
Savvas Kleanthous, Alan D Borthwick, David Brown, Cynthia L Burns-Kurtis, Matthew Campbell, John R Toomey

Bioorg Med Chem Lett· January 2010

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Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function.
Joseph A Erhardt, Connie L Erickson-Miller, Manuel Aivado, Melanie Abboud, Kodandaram Pillarisetti, John R Toomey

Exp Hematol· September 2009

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Antithrombotic potential of GW813893: a novel, orally active, active-site directed factor Xa inhibitor.
Melanie A Abboud, Saul J Needle, Cynthia L Burns-Kurtis, Richard E Valocik, Paul F Koster, John R Toomey

J Cardiovasc Pharmacol· July 2008

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Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.
Robert J Young, Alan D Borthwick, David Brown, Cynthia L Burns-Kurtis, Matthew Campbell, John R Toomey

Bioorg Med Chem Lett· January 2008

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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs.
Robert J Young, Alan D Borthwick, David Brown, Cynthia L Burns-Kurtis, Matthew Campbell, John R Toomey

Bioorg Med Chem Lett· January 2008

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Selective and dual action orally active inhibitors of thrombin and factor Xa.
Robert J Young, David Brown, Cynthia L Burns-Kurtis, Chuen Chan, Máire A Convery, John R Toomey

Bioorg Med Chem Lett· May 2007

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Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides.
Chuen Chan, Alan D Borthwick, David Brown, Cynthia L Burns-Kurtis, Matthew Campbell, John R Toomey

J Med Chem· April 2007

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The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa.
Aysar Aktimur, Melanie A Gabriel, David Gailani, John R Toomey

J Biol Chem· March 2003

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The antithrombotic efficacy of lotrafiban (SB 214857) in canine models of acute coronary thrombosis.
John R Toomey, James Samanen, Richard E Valocik, Paul F Koster, Frank C Barone

Curr Drug Targets Cardiovasc Haematol Disord· June 2002

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Inhibition of factor IX(a) is protective in a rat model of thromboembolic stroke.
John R Toomey, Richard E Valocik, Paul F Koster, Melanie A Gabriel, Matt McVey

Stroke· February 2002

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