Publications by authors named "John Reader"

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Proteostasis and resilience in the mechanically-stressed vascular endothelium.
Adam Keen, Feiran Zhang, John S Reader, Ellie Tzima

Curr Opin Physiol· August 2023

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Searching for the Good Life: Boundary Crossing, Co-Existence, and Conviviality.
Mark Coeckelbergh, John Reader

Postdigit Sci Educ· May 2023

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Author Correction: The guidance receptor plexin D1 is a mechanosensor in endothelial cells.
Vedanta Mehta, Kar-Lai Pang, Daniel Rozbesky, Katrin Nather, Adam Keen, John S Reader

Nature· May 2022

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Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells.
Adam N Keen, Luke A Payne, Vedanta Mehta, Alistair Rice, Lisa J Simpson, John S Reader

J Cell Biol· February 2022

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Footprint evidence of early hominin locomotor diversity at Laetoli, Tanzania.
Ellison J McNutt, Kevin G Hatala, Catherine Miller, James Adams, Jesse Casana, John Reader

Nature· December 2021

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Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway.
Vedanta Mehta, Kar-Lai Pang, Christopher S Givens, Zhongming Chen, Jianhua Huang, John S Reader

Sci Adv· July 2021

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Enchantment - Disenchantment-Re-Enchantment: Postdigital Relationships between Science, Philosophy, and Religion.
John Reader, Petar Jandrić, Michael A Peters, Ronald Barnett, Marcin Garbowski

Postdigit Sci Educ· July 2020

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From New Materialism to the Postdigital: Religious Responses to Environment and Technology.
John Reader

Postdigit Sci Educ· July 2020

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Mechanical Forces and Their Effect on the Ribosome and Protein Translation Machinery.
Lisa J Simpson, John S Reader, Ellie Tzima

Cells· March 2020

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The guidance receptor plexin D1 is a mechanosensor in endothelial cells.
Vedanta Mehta, Kar-Lai Pang, Daniel Rozbesky, Katrin Nather, Adam Keen, John S Reader

Nature· February 2020

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Mechanical Regulation of Protein Translation in the Cardiovascular System.
Lisa J Simpson, John S Reader, Ellie Tzima

Front Cell Dev Biol· January 2020

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Haemodynamics Regulate Fibronectin Assembly via PECAM.
Zhongming Chen, Chris Givens, John S Reader, Ellie Tzima

Sci Rep· January 2017

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Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).
James D Osborne, Thomas P Matthews, Tatiana McHardy, Nicolas Proisy, Kwai-Ming J Cheung, John C Reader

J Med Chem· June 2016

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The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma.
Mike I Walton, Paul D Eve, Angela Hayes, Alan T Henley, Melanie R Valenti, John C Reader

Oncotarget· January 2016

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Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction.
Margaret E McCormick, Mauricio Rojas, Tyler Moser-Katz, Ellie Tzima, John S Reader

PLoS One· October 2015

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A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens.
Abbas El Sahili, Si-Zhe Li, Julien Lang, Cornelia Virus, Sara Planamente, John Reader

PLoS Pathog· August 2015

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tRNAs as antibiotic targets.
Shaileja Chopra, John Reader

Int J Mol Sci· December 2014

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Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis.
Melissa G Works, Fangfang Yin, Catherine C Yin, Ying Yiu, Kenneth Shew, John Reader

J Immunol· October 2014

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Role of aminoacyl-tRNA synthetases in infectious diseases and targets for therapeutic development.
Varun Dewan, John Reader, Karin-Musier Forsyth

Top Curr Chem· August 2014

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Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells.
Caitlin Collins, Lukas D Osborne, Christophe Guilluy, Zhongming Chen, E Tim O'Brien, John S Reader

Nat Commun· June 2014

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Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase.
Shaileja Chopra, Andrés Palencia, Cornelia Virus, Ashutosh Tripathy, Brenda R Temple, John S Reader

Nat Commun· June 2013

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Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.
Michael Lainchbury, Thomas P Matthews, Tatiana McHardy, Kathy J Boxall, Michael I Walton, John C Reader

J Med Chem· November 2012

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CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs.
Mike I Walton, Paul D Eve, Angela Hayes, Melanie R Valenti, Alexis K De Haven Brandon, John C Reader

Clin Cancer Res· October 2012

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Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing.
John C Reader, Thomas P Matthews, Suki Klair, Kwai-Ming J Cheung, Jane Scanlon

J Med Chem· December 2011

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