Publications by authors named "John Rouse"

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Loss of SLX4IP leads to common fragile site instability and compromises DNA interstrand crosslink repair in vivo.
Andreas Ingham, Mukundhan Ramaswami, Ramanagouda Ramangoudr-Bhojappa, David Pladevall-Morera, Flavia De Santis, John Rouse

J Biol Chem· June 2025

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Functional dissection of the conserved C. elegans LEM-3/ANKLE1 nuclease reveals a crucial requirement for the LEM-like and GIY-YIG domains for DNA bridge processing.
Junfang Song, Peter Geary, Khadisha Salemova, John Rouse, Ye Hong

Nucleic Acids Res· March 2025

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PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability.
Vikram Tejwani, Thomas Carroll, Thomas Macartney, Susanne Bandau, Constance Alabert, John Rouse

Sci Rep· September 2024

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Chemo-Phosphoproteomic Profiling with ATR Inhibitors Berzosertib and Gartisertib Uncovers New Biomarkers and DNA Damage Response Regulators.
Rathan Jadav, Florian Weiland, Sylvie M Noordermeer, Thomas Carroll, Yuandi Gao, John Rouse

Mol Cell Proteomics· August 2024

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The histone chaperone SPT2 regulates chromatin structure and function in Metazoa.
Giulia Saredi, Francesco N Carelli, Stéphane G M Rolland, Giulia Furlan, Sandra Piquet, John Rouse

Nat Struct Mol Biol· March 2024

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Enablers and barriers to engaging under-served groups in research: Survey of the United Kingdom research professional's views.
Dorothy Coe, Theophile Bigirumurame, Meera Burgess, John Rouse, Caroline Wroe

NIHR Open Res· December 2023

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Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases.
Mateusz Gregorczyk, Graziana Pastore, Ivan Muñoz, Thomas Carroll, Johanna Streubel, John Rouse

Life Sci Alliance· July 2023

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Barriers and facilitators to primary care research: views of GP trainees and trainers.
Sarah Stephenson, Eugene Yee Hing Tang, Eugene Tang, Penny Williams, Hilary Allan, John Rouse

BJGP Open· June 2022

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CDKL5 kinase controls transcription-coupled responses to DNA damage.
Taran Khanam, Ivan Muñoz, Florian Weiland, Thomas Carroll, Michael Morgan, John Rouse

EMBO J· December 2021

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Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Alejandro Álvarez-Quilón, Jessica L Wojtaszek, Marie-Claude Mathieu, Tejas Patel, C Denise Appel, John Rouse

Mol Cell· June 2020

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Expanding the phenotype of the CDKL5 deficiency disorder: Are seizures mandatory?
Conor I MacKay, David Bick, Jeremy W Prokop, Ivan Muñoz, John Rouse

Am J Med Genet A· May 2020

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A complex comprising C15ORF41 and Codanin-1: the products of two genes mutated in congenital dyserythropoietic anaemia type I (CDA-I).
Maithili Shroff, Axel Knebel, Rachel Toth, John Rouse

Biochem J· May 2020

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Ways to unwind with HROB, a new player in homologous recombination.
Giulia Saredi, John Rouse

Genes Dev· October 2019

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Consensus Statement on Public Involvement and Engagement with Data Intensive Health Research.
Mhairi Aitken, Mary P Tully, Carol Porteous, Simon Denegri, Sarah Cunningham-Burley, John Rouse

Int J Popul Data Sci· February 2019

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Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase.
Ivan M Muñoz, Michael E Morgan, Julien Peltier, Florian Weiland, Mateusz Gregorczyk, John Rouse

EMBO J· December 2018

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Corrigendum to "Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR" [DNA Repair 6 (2007) 1536-1544].
Paul Jowsey, Nicholas A Morrice, C James Hastie, Hilary MacLauchlan, Rachel Toth, John Rouse

DNA Repair (Amst)· May 2018

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Corrigendum: Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage.
Ivan M Munoz, Paul A Jowsey, Rachel Toth, John Rouse

Nucleic Acids Res· December 2017

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RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.
Laura Feeney, Ivan M Muñoz, Christophe Lachaud, Rachel Toth, Paul L Appleton, John Rouse

Mol Cell· June 2017

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Comparing initial diagnostic excision biopsy of cutaneous malignant melanoma in primary versus secondary care: A study of Irish National data.
Sarah M Doherty, Louise M Jackman, John F Kirwan, Deirdre Dunne, Kieran G O'Connor, John M Rouse

Eur J Gen Pract· December 2016

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A route to new cancer therapies: the FA pathway is essential in BRCA1- or BRCA2-deficient cells.
Christophe Lachaud, John Rouse

Nat Struct Mol Biol· August 2016

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Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice.
Christophe Lachaud, Meghan Slean, Francesco Marchesi, Claire Lock, Edward Odell, John Rouse

Genes Dev· March 2016

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Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.
Christophe Lachaud, Alberto Moreno, Francesco Marchesi, Rachel Toth, J Julian Blow, John Rouse

Science· February 2016

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Prospective diagnostic test accuracy comparison of computed tomography during arterial portography and Primovist magnetic resonance imaging in the pre-operative assessment of colorectal cancer liver metastases.
Jai S Bagia, Alan Chai, Roger Chou, Christopher Chu, John Rouse

HPB (Oxford)· October 2015

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Improved genome editing in human cell lines using the CRISPR method.
Ivan M Munoz, Piotr Szyniarowski, Rachel Toth, John Rouse, Christophe Lachaud

PLoS One· June 2015

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USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.
Ana B Perez-Oliva, Christophe Lachaud, Piotr Szyniarowski, Ivan Muñoz, Thomas Macartney, John Rouse

EMBO J· February 2015

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