Publications by authors named "John Sears"

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Novel computational pipeline to identify target sites for broad spectrum antiviral drugs.
John D Sears, Konstantin I Popov, Paul A Sylvester, Rebekah Dickmander, Jennifer Diaz

Antiviral Res· January 2026

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-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity.
Anirban Ghoshal, John D Sears, Mohammad Anwar Hossain, Edwin G Tse, Stefanie Howell

J Med Chem· November 2025

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Identification of spirodioxolane nsP2 helicase inhibitors with antialphaviral activity.
Hans J Oh, John D Sears, Bose Muthu Ramalingam, Rahman Shah Zaib Saleem, Zachary W Davis-Gilbert

RSC Med Chem· October 2025

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Matching-adjusted indirect comparison between garadacimab and lanadelumab for the long-term prophylactic treatment of patients with hereditary angioedema.
Sarah Walsh, Anja Haltner, Meaghan Bartlett, John Sears, Yinglei Li

J Comp Eff Res· August 2025

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Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity.
Bose Muthu Ramalingam, Hans J Oh, John D Sears, Chun-Hsing Chen, Anand Vala

ACS Infect Dis· August 2025

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-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad Spectrum Antialphaviral Activity.
Anirban Ghoshal, John D Sears, Mohammad Anwar Hossain, Edwin G Tse, Stefanie Howell

bioRxiv· July 2025

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Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity.
Bose Muthu Ramalingam, John D Sears, Kacey M Talbot, Yuan-Wei Norman Su, Scott Houliston

J Med Chem· July 2025

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Novel Computational Pipeline to Identify Target Sites for Broad Spectrum Antiviral Drugs.
John D Sears, Konstantin I Popov, Paul Sylvester, Rebekah Dickmander, Jennifer Loome-Diaz

bioRxiv· July 2025

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Network Meta-Analysis of Pharmacological Therapies for Long-Term Prophylactic Treatment of Patients with Hereditary Angioedema.
Sarah Walsh, Meaghan Bartlett, Elizabeth M Salvo-Halloran, John Sears, Yinglei Li

Drugs R D· June 2025

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A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity.
Anirban Ghoshal, Edwin G Tse, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Eric M Merten, John D Sears

Sci Rep· March 2025

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RNA-targeted proteomics identifies YBX1 as critical for efficient HCMV mRNA translation.
Rebekah J Dickmander, Erik M Lenarcic, John D Sears, Andrew E Hale, Nathaniel J Moorman

Proc Natl Acad Sci U S A· March 2025

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A Covalent Chemical Probe for nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity.
Anirban Ghoshal, Edwin G Tse, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Eric M Merten, John D Sears

Res Sq· November 2024

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Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Eric M Merten, John D Sears, Tina M Leisner, P Brian Hardy, Anirban Ghoshal

Proc Natl Acad Sci U S A· October 2024

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Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of nsP2 Cysteine Protease with Antialphavirus Activity.
Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J Brown, Meganathan Nandakumar, John D Sears

J Med Chem· September 2024

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IL3-Driven T Cell-Basophil Crosstalk Enhances Antitumor Immunity.
Jian Wei, Colleen L Mayberry, Xiaoting Lv, Fangyan Hu, Taushif Khan, John D Sears

Cancer Immunol Res· July 2024

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An international survey assessing the effects of the duration of attack-free period on health-related quality of life for patients with hereditary angioedema.
Robbin Itzler, William R Lumry, John Sears, Julia Braverman, Yinglei Li

Orphanet J Rare Dis· June 2024

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Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of nsP2 Cysteine Protease with Anti-alphavirus Activity.
Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J Brown, Eric M Merten, John D Sears

bioRxiv· June 2024

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Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Eric M Merten, John D Sears, Tina M Leisner, Paul B Hardy, Anirban Ghoshal

bioRxiv· May 2024

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U-CAN-seq: A Universal Competition Assay by Nanopore Sequencing.
Jennifer Diaz, John Sears, Che-Kang Chang, Jane Burdick, Isabella Law

Viruses· April 2024

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Transcriptome analysis reveals organ-specific effects of 2-deoxyglucose treatment in healthy mice.
Ann E Wells, John J Wilson, Sarah E Heuer, John D Sears, Jian Wei

PLoS One· March 2024

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Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatment.
John J Wilson, Jian Wei, Andrea R Daamen, John D Sears, Elaine Bechtel

iScience· September 2023

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Transcriptome Analysis Reveals Organ-Specific Effects of 2-Deoxyglucose Treatment in Healthy Mice.
Ann E Wells, John J Wilson, John D Sears, Jian Wei, Sarah Heuer

bioRxiv· May 2023

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Targeting metabolism to reverse T-cell exhaustion in chronic viral infections.
John D Sears, Kevin J Waldron, Jian Wei, Chih-Hao Chang

Immunology· February 2021

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Histomorphological and Molecular Assessments of the Fixation Times Comparing Formalin and Ethanol-Based Fixatives.
Joon-Yong Chung, Joon Seon Song, Kris Ylaya, John D Sears, Lauren Choi

J Histochem Cytochem· February 2018

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Understanding the effects of electronic polarization and delocalization on charge-transport levels in oligoacene systems.
Christopher Sutton, Naga Rajesh Tummala, Travis Kemper, Saadullah G Aziz, John Sears

J Chem Phys· June 2017

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