Publications by authors named "John Simms"

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Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease.
Rebecca Bignold, Bushra Shammout, Jessica E Rowley, Mariaelena Repici, John Simms, Jill R Johnson

Respir Res· July 2022

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The effect of oxidative stress on the adenosine A receptor activity and signalling.
Idoia Company-Marín, Joseph Gunner, David Poyner, John Simms, Andrew R Pitt

Biochim Biophys Acta Biomembr· March 2025

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Classifying tetraspanins: A universal system for numbering residues and a proposal for naming structural motifs and subfamilies.
Luke M Broadbent, Alice J Rothnie, John Simms, Roslyn M Bill

Biochim Biophys Acta Biomembr· March 2024

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Membrane Protein Production in the Yeast P. pastoris.
Hoor Ayub, Michelle Clare, Luke Broadbent, John Simms, Alan D Goddard

Methods Mol Biol· July 2022

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The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation.
Ian Winfield, Kerry Barkan, Sarah Routledge, Nathan J Robertson, Matthew Harris, John Simms

Front Endocrinol (Lausanne)· March 2022

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Membrane protein extraction and purification using partially-esterified SMA polymers.
Olivia P Hawkins, Christine Parisa T Jahromi, Aiman A Gulamhussein, Stephanie Nestorow, Taranpreet Bahra, John Simms

Biochim Biophys Acta Biomembr· December 2021

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Ligand-induced conformational changes in a SMALP-encapsulated GPCR.
Sarah J Routledge, Mohammed Jamshad, Haydn A Little, Yu-Pin Lin, John Simms

Biochim Biophys Acta Biomembr· June 2020

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Preventive antibiotic treatment of calves: emergence of dysbiosis causing propagation of obese state-associated and mobile multidrug resistance-carrying bacteria.
Dorota A Dobrzanska, Matthew T F Lamaudière, Jessica Rollason, Lauren Acton, Michael Duncan, John Simms

Microb Biotechnol· May 2020

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Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors.
Sarah J Routledge, John Simms, Ashley Clark, Ho Yan Yeung, Mark J Wigglesworth

Biochim Biophys Acta Biomembr· March 2020

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Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics.
Sang-Min Lee, Yejin Jeong, John Simms, Margaret L Warner, David R Poyner

J Mol Biol· March 2020

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The Structure of the CGRP and Related Receptors.
John Simms, Sarah Routledge, Romez Uddin, David Poyner

Handb Exp Pharmacol· September 2019

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Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context.
Sian Bailey, Matthew Harris, Kerry Barkan, Ian Winfield, Matthew Thomas Harper, John Simms

Biochim Biophys Acta Biomembr· May 2019

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Functional characterisation of G protein-coupled receptors.
Romez Uddin, John Simms, David Poyner

Methods· September 2018

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h mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.
Duncan I Mackie, Fuad Al Mutairi, Reema B Davis, Daniel O Kechele, Natalie R Nielsen, John Simms

J Exp Med· September 2018

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Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex.
John Simms, Romez Uddin, Thomas P Sakmar, Joseph J Gingell, Michael L Garelja

Biochemistry· August 2018

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Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.
Thomas Coudrat, John Simms, Arthur Christopoulos, Denise Wootten, Patrick M Sexton

PLoS Comput Biol· November 2017

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Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach.
Michael J Woolley, John Simms, Juan Carlos Mobarec, Christopher A Reynolds, David R Poyner

Mol Cell Endocrinol· October 2017

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Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.
Michael J Woolley, Christopher A Reynolds, John Simms, Christopher S Walker, Juan Carlos Mobarec

Biochem Pharmacol· October 2017

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Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model.
Michael J Woolley, John Simms, Sifat Uddin, David R Poyner, Alex C Conner

Biochemistry· August 2017

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An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology.
Joseph J Gingell, John Simms, James Barwell, David R Poyner, Harriet A Watkins

Cell Discov· July 2016

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Erratum: An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology.
Joseph J Gingell, John Simms, James Barwell, David R Poyner, Harriet A Watkins

Cell Discov· July 2016

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The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.
Denise Wootten, Christopher A Reynolds, Kevin J Smith, Juan C Mobarec, Cassandra Koole, John Simms

Cell· June 2016

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A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.
Denise Wootten, Christopher A Reynolds, Cassandra Koole, Kevin J Smith, Juan C Mobarec, John Simms

Mol Pharmacol· March 2016

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Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
Jason M Booe, Christopher S Walker, James Barwell, Gabriel Kuteyi, John Simms

Mol Cell· June 2015

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Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.
Cassandra Koole, Denise Wootten, John Simms, Laurence J Miller, Arthur Christopoulos

J Pharmacol Exp Ther· April 2015

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