Respir Res July 2022 PMID 35831901

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease.

Rebecca Bignold, Bushra Shammout, Jessica E Rowley, Mariaelena Repici, John Simms, Jill R Johnson

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Mentions

Peak: 12 in Jul 2022

across 5 sources since Jul 2022

Extended reach

839,998

potential audience

Total likes

13,097

Video views

631,586

Mentions per month

Jul 2022 – Sep 2022

Where it's discussed

News34 articles
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Blogs6 articles
YouTube2 videos
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AI synopsis

What people are saying

The discussions show a strong overall agreement on the promising nature of the study, with words like 'potential long-term treatment' and 'game changer' conveying enthusiasm. Posts referencing specific molecules like CXCL12 and concepts such as airway remodeling reveal moderate engagement with the scientific content, while the focus on future treatment implications underscores perceived high impact.

AgreementModerate agreement

Most discussions reflect support and positive anticipation about the research, emphasizing its potential benefits for asthma treatment.

InterestHigh interest

Posts demonstrate high interest, with mentions of potential long-term solutions and disease management implications.

EngagementModerate engagement

Participants reference specific pathways like CXCL12 and pericytes, indicating moderate engagement with scientific details.

ImpactModerate impact

Several comments highlight the significance of the findings, viewing them as potential breakthroughs in respiratory medicine.

Abstract in brief

This study investigates how chemokine CXCL12 influences the accumulation of pericytes (cells supporting blood vessels) in the airway walls during allergic airway disease, leading to airway remodeling and lung dysfunction.
The researchers found that chronic allergic inflammation increases CXCR4 expression on pericytes, making them migrate more towards CXCL12, which results in thicker airway walls and respiratory issues.
Using a drug that blocks CXCL12, called LIT927, they successfully prevented pericyte migration and airway remodeling, suggesting that targeting the CXCL12-CXCR4 pathway could be a potential treatment for airway structural changes in allergic lung diseases.]

Read the full abstract

All mentions

Targeting CXCL12 to Prevent Airway Remodeling in Allergic Lung Disease

This study explores how chemokine CXCL12 influences pericyte accumulation in airway walls during allergy, leading to remodeling. Blocking CXCL12 with LIT927 prevented these changes, indicating a potential treatment for…

dr afzal critical care medicine · Aug 24, 2022 631,533 views

CXCL12 Chemokine Promotes Pericyte Migration in Allergic Airway Disease

This study investigates how chemokine CXCL12 influences pericyte accumulation in airway walls during allergic airway disease, leading to remodeling and lung dysfunction. Blocking CXCL12 with LIT927 prevents this…

Igor and Frankenstein · Aug 27, 2022 53 views

HABIB.LOAF@GMAIL.COM

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Obaid

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NP AGARWAL世界一フォローを目指しますAiming best in world.

@np_grwl · X

RT @medical_xpress: Potential long-term treatment for asthma found @astonuniversity https://t.co/lHHUgZ8Fd5 https://t.co/iNlXL57HP1

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RT @medical_xpress: Potential long-term treatment for asthma found @astonuniversity https://t.co/lHHUgZ8Fd5 https://t.co/iNlXL57HP1

Aug 9, 2022 · 4 shares · 21 followers View post →

O.Horvath

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RT @medical_xpress: Potential long-term treatment for asthma found @astonuniversity https://t.co/lHHUgZ8Fd5 https://t.co/iNlXL57HP1

Aug 9, 2022 · 4 shares · 905 followers View post →

Medical Xpress

@medical_xpress · X

Potential long-term treatment for asthma found @astonuniversity https://t.co/lHHUgZ8Fd5 https://t.co/iNlXL57HP1

Aug 9, 2022 · 6 likes · 4 shares · 173,260 followers View post →

Medical Xpress

@physorg_health · X

RT @medical_xpress: Potential long-term treatment for asthma found @astonuniversity https://t.co/lHHUgZ8Fd5 https://t.co/iNlXL57HP1

Aug 9, 2022 · 4 shares · 7,078 followers View post →

lungdevelopment

@lungdevelopmen1 · X

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease https://t.co/zWZ4auLuMl https://t.co/LCWcwKNt6M

Jul 15, 2022 · 62 followers View post →

lungdevelopment

@lungdevelopmen1 · X

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease https://t.co/S4u2o40aVB https://t.co/Ym5jr5o6sk

Jul 15, 2022 · 62 followers View post →

Cardio-Targets

@CardioTargets · X

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease https://t.co/LYTw8s6MLk

Jul 15, 2022 · 153 followers View post →

Interasma

@Interasma · X

RT @Aller_MD: Chemokine #CXCL12 drives #pericyte accumulation and airway #remodeling in #allergic #airway #disease. Open Access. https://t.…

Jul 14, 2022 · 4 shares · 2,450 followers View post →

SLaai

@SocLatAlergia · X

RT @Aller_MD: Chemokine #CXCL12 drives #pericyte accumulation and airway #remodeling in #allergic #airway #disease. Open Access. https://t.…

Jul 14, 2022 · 4 shares · 1,782 followers View post →

Fundación Libra

@FUNDACIONLIBRA · X

RT @Aller_MD: Chemokine #CXCL12 drives #pericyte accumulation and airway #remodeling in #allergic #airway #disease. Open Access. https://t.…

Jul 14, 2022 · 4 shares · 416 followers View post →

ARIAguideline

@ARIAGuideline · X

RT @Aller_MD: Chemokine #CXCL12 drives #pericyte accumulation and airway #remodeling in #allergic #airway #disease. Open Access. https://t.…

Jul 14, 2022 · 4 shares · 2,354 followers View post →

Juan C Ivancevich MD

@Aller_MD · X

Chemokine #CXCL12 drives #pericyte accumulation and airway #remodeling in #allergic #airway #disease. Open Access. https://t.co/v4mC3bMzW5 https://t.co/c0KhyL5Bha

Jul 14, 2022 · 3 likes · 4 shares · 7,477 followers View post →

Annelise Garrison (She/her)

@AnneliseGar · X

RT @JJohnsonLab: Pleased to announce the publication of our latest paper in Respiratory Research! #pericytes #asthma #CXCL12 @R_Bignold ht…

Jul 14, 2022 · 2 shares · 66 followers View post →

Rebecca Bignold PhD MRSB FHEA

@R_Bignold · X

RT @JJohnsonLab: Pleased to announce the publication of our latest paper in Respiratory Research! #pericytes #asthma #CXCL12 @R_Bignold ht…

Jul 14, 2022 · 2 shares · 30 followers View post →

Johnson Lab

@JJohnsonLab · X

Pleased to announce the publication of our latest paper in Respiratory Research! #pericytes #asthma #CXCL12 @R_Bignold https://t.co/fvFYvRGK93

Jul 14, 2022 · 2 likes · 2 shares · 78 followers View post →

Respiratory Medicine Portfolio

@RespiratoryBMC · X

New arrticle: Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease https://t.co/7tiaSGAI8r

Jul 13, 2022 · 3 likes · 3,404 followers View post →

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Targeting CXCL12 to Prevent Airway Remodeling in Allergic Lung Disease

CXCL12 Chemokine Promotes Pericyte Migration in Allergic Airway Disease