Publications by authors named "Johnathan D Guest"

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A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.
Mohammad M Sajadi, Abdolrahim Abbasi, Zahra Rikhtegaran Tehrani, Christine Siska, Rutilio Clark, Johnathan D Guest

Structure· July 2025

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SARS-CoV-2 RBD Scaffolded by AP205 or TIP60 Nanoparticles and Delivered as mRNA Elicits Robust Neutralizing Antibody Responses.
Johnathan D Guest, Yi Zhang, Daniel Flores, Emily Atkins, Kuishu Ren

Vaccines (Basel)· July 2025

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AlphaFold and Docking Approaches for Antibody-Antigen and Other Targets: Insights From CAPRI Rounds 47-55.
Ragul Gowthaman, Minjae Park, Rui Yin, Johnathan D Guest, Brian G Pierce

Proteins· January 2025

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A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.
Mohammad M Sajadi, Abdolrahim Abbasi, Zahra Rikhtegaran Tehrani, Christine Siska, Rutilio Clark, Johnathan D Guest

bioRxiv· October 2024

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Author Correction: Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials.
Bahar Ahani, Kevin M Tuffy, Anastasia A Aksyuk, Deidre Wilkins, Michael E Abram, Johnathan D Guest

Nat Commun· April 2024

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Impact of AlphaFold on structure prediction of protein complexes: The CASP15-CAPRI experiment.
Marc F Lensink, Guillaume Brysbaert, Nessim Raouraoua, Paul A Bates, Marco Giulini, Johnathan D Guest

Proteins· December 2023

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Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies.
Matthew C Metcalf, Benjamin M Janus, Rui Yin, Ruixue Wang, Johnathan D Guest

Nat Commun· July 2023

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Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials.
Bahar Ahani, Kevin M Tuffy, Anastasia A Aksyuk, Deidre Wilkins, Michael E Abram, Johnathan D Guest

Nat Commun· July 2023

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Molecular Characterization of AZD7442 (Tixagevimab-Cilgavimab) Neutralization of SARS-CoV-2 Omicron Subvariants.
Tiffany L Roe, Tyler Brady, Nicolette Schuko, Amy Nguyen, Jagadish Beloor, Johnathan D Guest

Microbiol Spectr· March 2023

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Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate.
Ruixue Wang, Saori Suzuki, Johnathan D Guest, Brigitte Heller, Maricar Almeda

Proc Natl Acad Sci U S A· March 2022

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An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development.
Jordan H Salas, Richard A Urbanowicz, Johnathan D Guest, Nicole Frumento, Alexis Figueroa

Gastroenterology· February 2022

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Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Daichao Wu, Alexander Kolesnikov, Rui Yin, Johnathan D Guest, Ragul Gowthaman

Nat Commun· January 2022

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Prediction of protein assemblies, the next frontier: The CASP14-CAPRI experiment.
Marc F Lensink, Guillaume Brysbaert, Théo Mauri, Nurul Nadzirin, Sameer Velankar, Johnathan D Guest

Proteins· December 2021

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Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants.
Rui Yin, Johnathan D Guest, Ghazaleh Taherzadeh, Ragul Gowthaman, Ipsa Mittra

PLoS Comput Biol· September 2021

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An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants.
Johnathan D Guest, Thom Vreven, Jing Zhou, Iain Moal, Jeliazko R Jeliazkov

Structure· June 2021

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Structure-Based and Rational Design of a Hepatitis C Virus Vaccine.
Johnathan D Guest, Brian G Pierce

Viruses· May 2021

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CoV3D: a database of high resolution coronavirus protein structures.
Ragul Gowthaman, Johnathan D Guest, Rui Yin, Jared Adolf-Bryfogle, William R Schief

Nucleic Acids Res· January 2021

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Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer.
Johnathan D Guest, Ruixue Wang, Khadija H Elkholy, Andrezza Chagas, Kinlin L Chao

Proc Natl Acad Sci U S A· January 2021

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Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.
Brian G Pierce, Zhen-Yong Keck, Ruixue Wang, Patrick Lau, Kyle Garagusi, Johnathan D Guest

J Virol· October 2020

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CoV3D: A database and resource for high resolution coronavirus protein structures.
Ragul Gowthaman, Johnathan D Guest, Rui Yin, Jared Adolf-Bryfogle, William R Schief

bioRxiv· June 2020

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Blind prediction of homo- and hetero-protein complexes: The CASP13-CAPRI experiment.
Marc F Lensink, Guillaume Brysbaert, Nurul Nadzirin, Sameer Velankar, Raphaël A G Chaleil, Johnathan D Guest

Proteins· December 2019

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Computational Modeling of Hepatitis C Virus Envelope Glycoprotein Structure and Recognition.
Johnathan D Guest, Brian G Pierce

Front Immunol· July 2019

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Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design.
Zhen-Yong Keck, Brian G Pierce, Patrick Lau, Janine Lu, Yong Wang, Johnathan D Guest

PLoS Pathog· May 2019

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Antigenicity and Immunogenicity of Differentially Glycosylated Hepatitis C Virus E2 Envelope Proteins Expressed in Mammalian and Insect Cells.
Richard A Urbanowicz, Ruixue Wang, John E Schiel, Zhen-Yong Keck, Melissa C Kerzic, Johnathan D Guest

J Virol· April 2019

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Zika virus NS5 protein antagonizes type I interferon production via blocking TBK1 activation.
Shaoli Lin, Shixing Yang, Jia He, Johnathan D Guest, Zexu Ma

Virology· January 2019

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