Publications by authors named "Joke A Bouwstra"

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Mild psoriasis as a suitable model for proof-of-mechanism in a phase 1B setting: Results from a double-blind placebo-controlled trial with guselkumab.
Jannik Rousel, Menthe E Bergmans, Lisa J Bruijnincx, Sissi Lin, Tessa Niemeyer-van der Kolk, Joke A Bouwstra

Br J Clin Pharmacol· December 2025

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Evaluation of PLGA, lipid-PLGA hybrid nanoparticles, and cationic pH-sensitive liposomes as tuberculosis vaccine delivery systems in a Mycobacterium tuberculosis challenge mouse model - A comparison.
Mikołaj M Szachniewicz, Malene A Neustrup, Susan J F van den Eeden, Krista E van Meijgaarden, Kees L M C Franken, Joke A Bouwstra

Int J Pharm· December 2024

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A Versatile, Low-Cost Modular Microfluidic System to Prepare Poly(Lactic-co-Glycolic Acid) Nanoparticles With Encapsulated Protein.
Malene Aaby Neustrup, Tom H M Ottenhoff, Wim Jiskoot, Joke A Bouwstra, Koen van der Maaden

Pharm Res· December 2024

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Similar Alterations of the Stratum Corneum Ceramide Profile in Atopic Dermatitis, Psoriasis, and Ichthyosis: Results from a Systematic Review and Meta-Analysis.
Jannik Rousel, Catherine Mergen, Jan W Schoones, Tessa Niemeyer-van der Kolk, Martijn B A van Doorn, Joke A Bouwstra

J Invest Dermatol· October 2024

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Lesional Psoriasis is Associated With Alterations in the Stratum Corneum Ceramide Profile and Concomitant Decreases in Barrier Function.
Jannik Rousel, Catherine Mergen, Menthe E Bergmans, Naomi B Klarenbeek, Tessa Niemeyer-van der Kolk, Joke A Bouwstra

Exp Dermatol· October 2024

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The phase behavior of skin-barrier lipids: A combined approach of experiments and simulations.
Parashara Shamaprasad, Andreea Nădăban, Christopher R Iacovella, Gerrit S Gooris, Annette L Bunge, Joke A Bouwstra

Biophys J· September 2024

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Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial.
Jannik Rousel, Catherine Mergen, Menthe E Bergmans, Lisa J Bruijnincx, Marieke L de Kam, Joke A Bouwstra

J Lipid Res· August 2024

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The Sphingosine and Phytosphingosine Ceramide Ratio in Lipid Models Forming the Short Periodicity Phase: An Experimental and Molecular Simulation Study.
Andreea Nădăban, Chloe O Frame, Dounia El Yachioui, Gerrit S Gooris, Robert M Dalgliesh, Joke A Bouwstra

Langmuir· July 2024

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The molecular arrangement of ceramides in the unit cell of the long periodicity phase of stratum corneum models shows a high adaptability to different ceramide head group structures.
Andreea Nădăban, Gerrit S Gooris, Charlotte M Beddoes, Robert M Dalgliesh, Marc Malfois, Joke A Bouwstra

Biochim Biophys Acta Biomembr· June 2024

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Guselkumab induction therapy demonstrates long-lasting efficacy in patients with mild psoriasis, results from a randomized, placebo-controlled exploratory clinical trial.
Jannik Rousel, Menthe E Bergmans, Laura W J van der Meulen, Lisa Pagan, Digna T de Bruin, Joke A Bouwstra

J Am Acad Dermatol· February 2024

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Intradermal Vaccination with PLGA Nanoparticles via Dissolving Microneedles and Classical Injection Needles.
Jihui Lee, Malene A Neustrup, Bram Slütter, Conor O'Mahony, Joke A Bouwstra

Pharm Res· February 2024

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Lesional skin of seborrheic dermatitis patients is characterized by skin barrier dysfunction and correlating alterations in the stratum corneum ceramide composition.
Jannik Rousel, Andreea Nădăban, Mahdi Saghari, Lisa Pagan, Ahnjili Zhuparris, Joke A Bouwstra

Exp Dermatol· January 2024

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The skin barrier: An extraordinary interface with an exceptional lipid organization.
Joke A Bouwstra, Andreea Nădăban, Wim Bras, Clare McCabe, Annette Bunge

Prog Lipid Res· November 2023

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Efficient fabrication of thermo-stable dissolving microneedle arrays for intradermal delivery of influenza whole inactivated virus vaccine.
Jihui Lee, Martin Beukema, Oliwia A Zaplatynska, Conor O'Mahony, Wouter L J Hinrichs, Joke A Bouwstra

Biomater Sci· October 2023

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Treatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial.
Jannik Rousel, Mahdi Saghari, Lisa Pagan, Andreea Nădăban, Tom Gambrah, Joke A Bouwstra

Int J Mol Sci· September 2023

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Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models.
Andreea Nădăban, Jannik Rousel, Dounia El Yachioui, Gerrit S Gooris, Charlotte M Beddoes, Joke A Bouwstra

J Lipid Res· August 2023

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The effect of PPAR isoform (de)activation on the lipid composition in full-thickness skin models.
Richard W J Helder, Jannik Rousel, Walter A Boiten, Gerrit S Gooris, Andreea Nadaban, Joke A Bouwstra

Exp Dermatol· April 2023

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Using molecular simulation to understand the skin barrier.
Parashara Shamaprasad, Chloe O Frame, Timothy C Moore, Alexander Yang, Christopher R Iacovella, Joke A Bouwstra

Prog Lipid Res· November 2022

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Phytosphingosine ceramide mainly localizes in the central layer of the unique lamellar phase of skin lipid model systems.
Andreea Nădăban, Gerrit S Gooris, Charlotte M Beddoes, Robert M Dalgliesh, Joke A Bouwstra

J Lipid Res· September 2022

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The importance of ceramide headgroup for lipid localisation in skin lipid models.
Charlotte M Beddoes, Gert S Gooris, David J Barlow, M Jayne Lawrence, Robert M Dalgliesh, Joke A Bouwstra

Biochim Biophys Acta Biomembr· June 2022

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The Use of a Staggered Herringbone Micromixer for the Preparation of Rigid Liposomal Formulations Allows Efficient Encapsulation of Antigen and Adjuvant.
Fernando Lozano Vigario, Noémi Anna Nagy, Meike H The, Rinske Sparrius, Joke A Bouwstra

J Pharm Sci· April 2022

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Coating gold nanorods with self-assembling peptide amphiphiles promotes stability and facilitates two-photon imaging.
Elena A Egorova, Gabriela Arias-Alpizar, Redmar C Vlieg, Gert S Gooris, Joke A Bouwstra

J Mater Chem B· March 2022

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Effects of ozone on stratum corneum lipid integrity and assembly.
Benedetta Petracca, Andreea Nădăban, Marc Eeman, Gert S Gooris, Joke A Bouwstra

Chem Phys Lipids· October 2021

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Increased Levels of Short-Chain Ceramides Modify the Lipid Organization and Reduce the Lipid Barrier of Skin Model Membranes.
Lorretta E Uche, Gerrit S Gooris, Joke A Bouwstra, Charlotte M Beddoes

Langmuir· August 2021

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Antigen Uptake After Intradermal Microinjection Depends on Antigen Nature and Formulation, but Not on Injection Depth.
Romain J T Leboux, Pim Schipper, Toni M M van Capel, Lily Kong, Koen van der Maaden, Joke A Bouwstra

Front Allergy· April 2021

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