Publications by authors named "Jon D Williams"

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Development and Optimization of an Electrospray Diverter for Reduced Background Signal in Ambient Ionization Sources.
Seth M Eisenberg, Alena N Joignant, Jonathan D Trumbull, David Hernandez, David Chang-Yen, Jon D Williams

J Am Soc Mass Spectrom· December 2025

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Application and Characterization of Novel Mid-IR Glucoloop Laser for Mass Spectrometry Imaging and Small Molecule Screening.
Seth M Eisenberg, Emily R Bruce, Sarah M Ashbacher, Mary F Wang, James W Sawicki, Jon D Williams

Anal Chem· November 2025

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A role for the autophagy receptor NBR1 in the degradation of tau aggregates.
Marie Neu, Iwan Parfentev, Gregory K Potts, Nina Stöberl, Jürgen Korffmann, Jon D Williams

Neurobiol Dis· October 2025

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Metabolite fingerprinting by infrared matrix-assisted laser desorption electrospray ionization mass spectrometry.
Alena N Joignant, Fan Pu, Shaun M McLoughlin, James W Sawicki, Andrew J Radosevich, Jon D Williams

SLAS Technol· June 2025

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Automated High-Throughput Affinity Capture-Mass Spectrometry Platform with Data-Independent Acquisition.
Hui Jing, Paul L Richardson, Gregory K Potts, Sameera Senaweera, Violeta L Marin, Jon D Williams

J Proteome Res· February 2025

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Detection of Noncovalent Protein-Ligand Complexes by IR-MALDESI-MS.
Kevan T Knizner, Fan Pu, James W Sawicki, Andrew J Radosevich, Scott A Ugrin, Jon D Williams

J Am Soc Mass Spectrom· August 2024

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Collaborative robotics to enable ultra-high-throughput IR-MALDESI.
John Shanley, Fan Pu, Jon D Williams, Nathaniel L Elsen, Sujatha M Gopalakrishnan

SLAS Technol· August 2024

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Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson's disease pathogenesis.
Casey J Lumpkin, Hiral Patel, Gregory K Potts, Shilpi Chaurasia, Lauren Gibilisco, Jon D Williams

Mol Brain· May 2024

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Ultra-high-throughput mass spectrometry in drug discovery: fundamentals and recent advances.
Jon D Williams, Fan Pu, James W Sawicki, Nathaniel L Elsen

Expert Opin Drug Discov· March 2024

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New Platform for Label-Free, Proximal Cellular Pharmacodynamic Assays: Identification of Glutaminase Inhibitors Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry.
Fan Pu, Andrew J Radosevich, Brett G Bruckner, David A Fontaine, Sanjay C Panchal, Jon D Williams

ACS Chem Biol· April 2023

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High-Throughput Deconvolution of Intact Protein Mass Spectra for the Screening of Covalent Inhibitors.
Fan Pu, Kevan T Knizner, Matthew T Robey, Andrew J Radosevich, Scott A Ugrin, Jon D Williams

J Am Soc Mass Spectrom· December 2022

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Next-Generation Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Source for Mass Spectrometry Imaging and High-Throughput Screening.
Kevan T Knizner, Jacob P Guymon, Kenneth P Garrard, Guy Bouvrée, Jeffrey Manni, Jon D Williams

J Am Soc Mass Spectrom· November 2022

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High-Throughput Intact Protein Analysis for Drug Discovery Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry.
Fan Pu, Scott A Ugrin, Andrew J Radosevich, David Chang-Yen, James W Sawicki, Jon D Williams

Anal Chem· October 2022

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Normalization techniques for high-throughput screening by infrared matrix-assisted laser desorption electrospray ionization mass spectrometry.
Kevan T Knizner, Michael C Bagley, Fan Pu, Nathaniel L Elsen, Jon D Williams

J Mass Spectrom· June 2022

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Ultra-High-Throughput Ambient MS: Direct Analysis at 22 Samples per Second by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry.
Andrew J Radosevich, Fan Pu, David Chang-Yen, James W Sawicki, Nari N Talaty, Jon D Williams

Anal Chem· March 2022

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Optimized C-Trap Timing of an Orbitrap 240 Mass Spectrometer for High-Throughput Screening and Native MS by IR-MALDESI.
Kevan T Knizner, Michael C Bagley, Kenneth P Garrard, Jan-Peter Hauschild, Fan Pu, Jon D Williams

J Am Soc Mass Spectrom· February 2022

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High-Throughput Label-Free Biochemical Assays Using Infrared Matrix-Assisted Desorption Electrospray Ionization Mass Spectrometry.
Fan Pu, Andrew J Radosevich, James W Sawicki, David Chang-Yen, Nari N Talaty, Jon D Williams

Anal Chem· May 2021

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Emerging Chromatography-Free High-Throughput Mass Spectrometry Technologies for Generating Hits and Leads.
Fan Pu, Nathaniel L Elsen, Jon D Williams

ACS Med Chem Lett· November 2020

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Correction to Comprehensive Middle-Down Mass Spectrometry Characterization of an Antibody-Drug Conjugate by Combined Ion Activation Methods.
Eleanor Watts, Jon D Williams, Laura J Miesbauer, Milan Bruncko, Jennifer S Brodbelt

Anal Chem· September 2020

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Comprehensive Middle-Down Mass Spectrometry Characterization of an Antibody-Drug Conjugate by Combined Ion Activation Methods.
Eleanor Watts, Jon D Williams, Laura J Miesbauer, Milan Bruncko, Jennifer S Brodbelt

Anal Chem· July 2020

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A Dual-Purpose Bromocoumarin Tag Enables Deep Profiling of the Cellular Cysteinome.
Adam J Rabalski, Jon D Williams, Ryan A McClure, Anil Vasudevan, Aleksandra Baranczak

Proteomics· June 2019

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Native Reversed-Phase Liquid Chromatography: A Technique for LCMS of Intact Antibody-Drug Conjugates.
Tse-Hong Chen, Yun Yang, Zhaorui Zhang, Cexiong Fu, Qunying Zhang, Jon D Williams

Anal Chem· February 2019

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Impact of Mass Spectrometry-Based Technologies and Strategies on Chemoproteomics as a Tool for Drug Discovery.
Ryan A McClure, Jon D Williams

ACS Med Chem Lett· August 2018

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Direct screening of enzyme activity using infrared matrix-assisted laser desorption electrospray ionization.
Milad Nazari, Måns Ekelöf, Sitora Khodjaniyazova, Nathaniel L Elsen, Jon D Williams

Rapid Commun Mass Spectrom· November 2017

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Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group.
Mercedes Lobera, Kevin P Madauss, Denise T Pohlhaus, Quentin G Wright, Mark Trocha, Jon D Williams

Nat Chem Biol· May 2013

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