Publications by authors named "Jon Holy"

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Mechanoresponsive patterns of KLF2, 4, 5, and 6 expression differ among subclones from a single mammary tumor.
Rafaela Marocci Lima Pimenta, Cara Skon-Hegg, Teresa Rose-Hellekant, Jon Holy

Acta Histochem· June 2025

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Synthesis and biological evaluation of a novel anticancer agent CBISC that induces DNA damage response and diminishes levels of mutant-p53.
Conor T Ronayne, Sravan K Jonnalagadda, Shirisha Jonnalagadda, Grady L Nelson, Lucas N Solano, Jon Holy

Biochem Biophys Res Commun· July 2021

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Associated anisotropy of intrinsic NAD(P)H for monitoring changes in the metabolic activities of breast cancer cells (4T1) in three-dimensional collagen matrix.
Anh T Q Cong, Rafaela M L Pimenta, Jon Holy, Ahmed A Heikal

Phys Chem Chem Phys· June 2021

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Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Silvia Magalhães-Novais, Juan C Bermejo-Millo, Rute Loureiro, Katia A Mesquita, M Rosário Domingues, Jon Holy

Autophagy· February 2020

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Development of Novel Silyl Cyanocinnamic Acid Derivatives as Metabolic Plasticity Inhibitors for Cancer Treatment.
Grady L Nelson, Conor T Ronayne, Lucas N Solano, Sravan K Jonnalagadda, Shirisha Jonnalagadda, Jon Holy

Sci Rep· December 2019

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Novel N,N-dialkyl cyanocinnamic acids as monocarboxylate transporter 1 and 4 inhibitors.
Shirisha Jonnalagadda, Sravan K Jonnalagadda, Conor T Ronayne, Grady L Nelson, Lucas N Solano, Jon Holy

Oncotarget· March 2019

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Two-photon fluorescence lifetime imaging of intrinsic NADH in three-dimensional tumor models.
Anh Cong, Rafaela M L Pimenta, Hong Bok Lee, Venkatram Mereddy, Jon Holy

Cytometry A· January 2019

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Toxicity of lupane derivatives on anionic membrane models, isolated rat mitochondria and selected human cell lines: Role of terminal alkyl chains.
Filipa S Carvalho, Catarina M Morais, Jon Holy, Dmytro Krasutsky, Sergiy V Yemets

Chem Biol Interact· December 2018

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A tRNA fragment, tRF5-Glu, regulates BCAR3 expression and proliferation in ovarian cancer cells.
Kun Zhou, Kevin W Diebel, Jon Holy, Andrew Skildum, Evan Odean

Oncotarget· November 2017

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Synthesis and biological evaluation of 2-alkoxycarbonylallyl esters as potential anticancer agents.
Conor T Ronayne, Lucas N Solano, Grady L Nelson, Erica A Lueth, Skyler L Hubbard, Jon Holy

Bioorg Med Chem Lett· February 2017

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A Cancer Cell Spheroid Assay to Assess Invasion in a 3D Setting.
Eric B Berens, Jon M Holy, Anna T Riegel, Anton Wellstein

J Vis Exp· November 2015

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Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.
Ana C Moreira, Ana F Branco, Susana F Sampaio, Teresa Cunha-Oliveira, Tatiana R Martins, Jon Holy

Biochim Biophys Acta· December 2014

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New derivatives of lupane triterpenoids disturb breast cancer mitochondria and induce cell death.
Teresa L Serafim, Filipa S Carvalho, Telma C Bernardo, Gonçalo C Pereira, Edward Perkins, Jon Holy

Bioorg Med Chem· November 2014

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Vital imaging of multicellular spheroids.
Paulo J Oliveira, Edward L Perkins, Jon Holy

Methods Mol Biol· April 2014

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Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition.
Telma C Bernardo, Teresa Cunha-Oliveira, Teresa L Serafim, Jon Holy, Dmytro Krasutsky

Bioorg Med Chem· December 2013

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Differentiation-dependent doxorubicin toxicity on H9c2 cardiomyoblasts.
Ana F Branco, Susana F Sampaio, Ana C Moreira, Jon Holy, Kendall B Wallace

Cardiovasc Toxicol· December 2012

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Isoproterenol cytotoxicity is dependent on the differentiation state of the cardiomyoblast H9c2 cell line.
Ana F Branco, Sandro L Pereira, Ana C Moreira, Jon Holy, Vilma A Sardão

Cardiovasc Toxicol· September 2011

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Biologic activity of a dinuclear Pd(II)-spermine complex toward human breast cancer.
Sónia M Fiuza, Jon Holy, Luis A E Batista de Carvalho, Maria P M Marques

Chem Biol Drug Des· June 2011

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Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells.
Teresa L Serafim, Filipa S Carvalho, Maria P M Marques, Rita Calheiros, Tiago Silva, Jon Holy

Chem Res Toxicol· May 2011

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Dimethylaminopyridine derivatives of lupane triterpenoids are potent disruptors of mitochondrial structure and function.
Jon Holy, Oksana Kolomitsyna, Dmytro Krasutsky, Paulo J Oliveira, Edward Perkins

Bioorg Med Chem· August 2010

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Differentiation of pluripotent stem cells on multiwalled carbon nanotubes.
Jon Holy, Edward Perkins, Xun Yu

Annu Int Conf IEEE Eng Med Biol Soc· April 2010

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Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts.
Vilma A Sardão, Paulo J Oliveira, Jon Holy, Catarina R Oliveira, Kendall B Wallace

Cancer Chemother Pharmacol· September 2009

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Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets.
Vilma A Sardão, Paulo J Oliveira, Jon Holy, Catarina R Oliveira, Kendall B Wallace

Cell Biol Toxicol· June 2009

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Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells--nuclear vs. mitochondrial effects.
Teresa L Serafim, Júlio A C Matos, Vilma A Sardão, Gonçalo C Pereira, Ana F Branco, Jon Holy

Biochem Pharmacol· December 2008

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Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.
Gonçalo C Pereira, Ana F Branco, Júlio A C Matos, Sandro L Pereira, Donna Parke, Jon Holy

J Pharmacol Exp Ther· November 2007

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