Publications by authors named "Jon R Appel"

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Correction to "Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput 'Unbiased' Screening Campaign".
Skye R Doering, Katie Freeman, Ginamarie Debevec, Phaedra Geer, Radleigh G Santos, Jon R Appel

J Med Chem· May 2023

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Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.
Skye R Doering, Katie Freeman, Ginamarie Debevec, Phaedra Geer, Radleigh G Santos, Jon R Appel

J Med Chem· May 2021

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Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa-Arg-(pI)DPhe-Xaa-NH.
Skye R Doering, Katie T Freeman, Sathya M Schnell, Erica M Haslach, Marvin Dirain, Jon R Appel

J Med Chem· May 2017

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Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).
Erica M Haslach, Huisuo Huang, Marvin Dirain, Ginamarie Debevec, Phaedra Geer, Jon R Appel

J Med Chem· June 2014

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Identification of a small molecule that selectively inhibits mouse PC2 over mouse PC1/3: a computational and experimental study.
Austin B Yongye, Mirella Vivoli, Iris Lindberg, Jon R Appel, Richard A Houghten

PLoS One· September 2013

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Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries.
Clemencia Pinilla, Bruce S Edwards, Jon R Appel, Tina Yates-Gibbins, Marc A Giulianotti

Mol Pharmacol· September 2013

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Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches.
José L Medina-Franco, Bruce S Edwards, Clemencia Pinilla, Jon R Appel, Marc A Giulianotti

J Chem Inf Model· June 2013

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The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors.
Radleigh G Santos, Jon R Appel, Marc A Giulianotti, Bruce S Edwards, Larry A Sklar

Molecules· May 2013

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The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.
Christine Levesque, Martin Fugère, Anna Kwiatkowska, Frédéric Couture, Roxane Desjardins, Jon R Appel

J Med Chem· December 2012

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Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries.
Clemencia Pinilla, Jon R Appel, Valeria Judkowski, Richard A Houghten

Curr Protoc Immunol· November 2012

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Inhibitor screening of proprotein convertases using positional scanning libraries.
Iris Lindberg, Jon R Appel

Methods Mol Biol· March 2012

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GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4+ T cells following smallpox vaccination.
Valeria Judkowski, Alcinette Bunying, Feng Ge, Jon R Appel, Kingyee Law

PLoS One· March 2012

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Integrating computational and mixture-based screening of combinatorial libraries.
Austin B Yongye, Clemencia Pinilla, Jose L Medina-Franco, Marc A Giulianotti, Colette T Dooley, Jon R Appel

J Mol Model· June 2011

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Use and implications of the harmonic mean model on mixtures for basic research and drug discovery.
Radleigh G Santos, Marc A Giulianotti, Colette T Dooley, Clemencia Pinilla, Jon R Appel

ACS Comb Sci· May 2011

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Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.
Austin B Yongye, Jon R Appel, Marc A Giulianotti, Colette T Dooley, Jose L Medina-Franco

Bioorg Med Chem· August 2009

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Synthetic small-molecule prohormone convertase 2 inhibitors.
Dorota Kowalska, Jin Liu, Jon R Appel, Akihiko Ozawa, Adel Nefzi

Mol Pharmacol· March 2009

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Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.
Karina Martínez-Mayorga, Jose L Medina-Franco, Marc A Giulianotti, Clemencia Pinilla, Colette T Dooley, Jon R Appel

Bioorg Med Chem· June 2008

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Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
Richard A Houghten, Clemencia Pinilla, Marc A Giulianotti, Jon R Appel, Colette T Dooley

J Comb Chem· February 2008

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Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries.
Adel Nefzi, John M Ostresh, Jon R Appel, Jean Bidlack, Colette T Dooley

Bioorg Med Chem Lett· August 2006

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In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands.
Richard A Houghten, Colette T Dooley, Jon R Appel

AAPS J· May 2006

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De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library.
Richard A Houghten, Colette T Dooley, Jon R Appel

Bioorg Med Chem Lett· April 2004

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Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.
Clemencia Pinilla, Jon R Appel, Eva Borràs, Richard A Houghten

Nat Med· January 2003

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Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries.
Clemencia Pinilla, Jon R Appel, Richard A Houghten

Curr Protoc Immunol· November 2001

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