Publications by authors named "Jonathan A Doorn"

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Subacute exposure of male adolescent rats to 2,2',5,5'-tetrachlorobiphenyl-4-ol via a polymeric implant causes gene expression changes in the brain and metabolomic disruption in serum.
Hui Wang, Amanda J Bullert, Morgan J Linahon, Michael E Dailey, Jonathan A Doorn

Toxicology· June 2025

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Pharmaceutical Sciences: Insights and Observations from Academic Chairs and Vice Chairs.
Kristy M Ainslie, Albert A Bowers, Robert H Chichewicz, Lara S Collier, Jonathan A Doorn

AAPS J· February 2025

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Astrocyte Mitochondria Are a Sensitive Target of PCB52 and its Human-Relevant Metabolites.
Neha Paranjape, Stefan Strack, Hans-Joachim Lehmler, Jonathan A Doorn

ACS Chem Neurosci· August 2024

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A Novel Analog of the Natural Product Fraxinellone Protects against Endogenous and Exogenous Neurotoxicants.
Anna E Bartman, Mersad Raeisi, Clarence D Peiris, Isabella E Jacobsen, David B C Martin, Jonathan A Doorn

ACS Chem Neurosci· July 2024

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Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology.
Fatema Currim, Reeya Tanwar, Josephine M Brown-Leung, Neha Paranjape, Jennifer Liu, Jonathan A Doorn

Neurotoxicology· July 2024

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Detection and disaggregation of amyloid fibrils by luminescent amphiphilic platinum(II) complexes.
Zhuoheng Li, Akalanka B Ekanayake, Anna E Bartman, Jonathan A Doorn, Alexei V Tivanski

Dalton Trans· May 2024

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Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease.
Paul Anthony Martinez, Vanessa Elia Martinez, Sheela Rani, Meredith Murrell, Martin Javors, Jonathan Alan Doorn

Brain Behav· September 2023

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Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure.
Amanda Bullert, Xueshu Li, Zhang Chunyun, Kendra Lee, Casey F Pulliam, Jonathan A Doorn

Environ Toxicol Pharmacol· September 2023

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Disposition and Metabolomic Effects of 2,2',5,5'-Tetrachlorobiphenyl in Female Rats Following Intraperitoneal Exposure.
Amanda Bullert, Xueshu Li, Chunyun Zhang, Kendra Lee, Casey F Pulliam, Jonathan A Doorn

bioRxiv· August 2023

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Structure-Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity.
Neha Paranjape, Laura E Dean, Andres Martinez, Ronald B Tjalkens, Hans-Joachim Lehmler, Jonathan A Doorn

Chem Res Toxicol· June 2023

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Characterization of Catecholaldehyde Adducts with Carnosine and l-Cysteine Reveals Their Potential as Biomarkers of Catecholaminergic Stress.
Rachel A Crawford, Ettore Gilardoni, T Blake Monroe, Luca Regazzoni, Ethan J Anderson, Jonathan A Doorn

Chem Res Toxicol· October 2021

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In vitro inhibition of glutathione-S-transferase by dopamine and its metabolites, 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetic acid.
Rachel A Crawford, Kate R Bowman, Brianna S Cagle, Jonathan A Doorn

Neurotoxicology· September 2021

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The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review.
Amanda J Bullert, Jonathan A Doorn, Hanna E Stevens, Hans-Joachim Lehmler

Chem Res Toxicol· September 2021

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Enhanced Catecholamine Flux and Impaired Carbonyl Metabolism Disrupt Cardiac Mitochondrial Oxidative Phosphorylation in Diabetes Patients.
Margaret-Ann M Nelson, Jimmy T Efird, Kimberly A Kew, Lalage A Katunga, T Blake Monroe, Jonathan A Doorn

Antioxid Redox Signal· August 2021

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Fragment-Based Nuclear Magnetic Resonance Screen against a Regulator of G Protein Signaling Identifies a Binding "Hot Spot".
Michael P Hayes, Joseph B O'Brien, Rachel A Crawford, C Andrew Fowler, Liping Yu, Jonathan A Doorn

Chembiochem· May 2021

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A Soft Mechanical Phenotype of SH-SY5Y Neuroblastoma and Primary Human Neurons Is Resilient to Oligomeric Aβ(1-42) Injury.
Terra M Kruger, Kendra J Bell, Thiranjeewa I Lansakara, Alexei V Tivanski, Jonathan A Doorn

ACS Chem Neurosci· March 2020

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Atropselective Oxidation of 2,2',3,3',4,6'-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity.
Eric Uwimana, Brianna Cagle, Coby Yeung, Xueshu Li, Eric V Patterson, Jonathan A Doorn

Toxicol Sci· October 2019

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Reduced Extracellular Matrix Stiffness Prompts SH-SY5Y Cell Softening and Actin Turnover To Selectively Increase Aβ(1-42) Endocytosis.
Terra M Kruger, Kendra J Bell, Thiranjeewa I Lansakara, Alexei V Tivanski, Jonathan A Doorn

ACS Chem Neurosci· March 2019

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Biogenic Aldehyde-Mediated Mechanisms of Toxicity in Neurodegenerative Disease.
Brianna S Cagle, Rachel A Crawford, Jonathan A Doorn

Curr Opin Toxicol· February 2019

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Biochemical characterization of the catecholaldehyde reactivity of L-carnosine and its therapeutic potential in human myocardium.
Margaret-Ann M Nelson, Zachariah J Builta, T Blake Monroe, Jonathan A Doorn, Ethan J Anderson

Amino Acids· January 2019

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Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells.
Eric A Rodriguez, Brigitte C Vanle, Jonathan A Doorn, Hans-Joachim Lehmler, Larry W Robertson

Environ Toxicol Pharmacol· September 2018

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Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures.
Christopher R Bodle, Josephine H Schamp, Joseph B O'Brien, Michael P Hayes, Meng Wu, Jonathan A Doorn

SLAS Discov· April 2018

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PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells.
Sabah H Enayah, Brigitte C Vanle, Laurence J Fuortes, Jonathan A Doorn, Gabriele Ludewig

Toxicology· February 2018

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Inactivation of glyceraldehyde-3-phosphate dehydrogenase by the dopamine metabolite, 3,4-dihydroxyphenylacetaldehyde.
Brigitte C Vanle, Virginia R Florang, Daryl J Murry, Arturo L Aguirre, Jonathan A Doorn

Biochem Biophys Res Commun· October 2017

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Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.
Christopher R Bodle, Duncan I Mackie, Michael P Hayes, Josephine H Schamp, Michael R Miller, Jonathan A Doorn

J Nat Prod· July 2017

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