Publications by authors named "Jonathan Alder"

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Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health.
Ulalume Hernández-Arciga, Jun Kyoung Kim, Jacob L Fisher, Alexander Tyshkovskiy, Alibek Moldakozhayev, Jonathan K Alder

JCI Insight· December 2025

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Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex.
Samantha L Sanford, Mareike Badstübner, Michael Gerber, William Mannherz, Noah Lampl, Jonathan K Alder

Nat Commun· December 2025

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Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis.
Kyle Inman, Jonathan Chernus, Myoungkeun Lee, Jonathan K Alder, Faraaz Ali Shah

Crit Care Explor· November 2025

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Belatacept as an alternative immunosuppressive agent for bone marrow-sparing in idiopathic pulmonary fibrosis lung transplant recipients with short telomeres.
Stefanie J Hannan, Carlo J Iasella, Michel Sciullo, Cody Moore, Ryan Rivosecci, Jonathan K Alder

J Heart Lung Transplant· October 2025

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Chemotherapeutic 6-thio-2'-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex.
Samantha L Sanford, Mareike Badstübner, Michael Gerber, William Mannherz, Noah Lampl, Jonathan K Alder

bioRxiv· June 2025

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Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner.
Ulalume Hernández-Arciga, Ceda Stamenkovic, Shweta Yadav, Chiara Nicoletti, Wafaa N Albalawy, Jonathan K Alder

Sci Adv· April 2025

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SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms.
Euxhen Hasanaj, Delphine Beaulieu, Cankun Wang, Qianjiang Hu, Marta Bueno, Jonathan Alder

bioRxiv· December 2024

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IL-10 Is Critical for Regulation of Cytotoxic CD4+NKG7+ T Cells in Lung Allograft Rejection but Is Not Required for Allograft Acceptance.
Antu Das, Xingan Wang, Kaitlyn Devonshire, Emily J Lyons, Iulia Popescu, Jonathan K Alder

J Immunol· September 2024

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A persistent variant telomere sequence in a human pedigree.
Angela M Hinchie, Samantha L Sanford, Kelly E Loughridge, Rachel M Sutton, Anishka H Parikh, Jonathan K Alder

Nat Commun· June 2024

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Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury.
Faraaz A Shah, Harinath Bahudhanapati, Mao Jiang, Mohammadreza Tabary, Rick van der Geest, Jonathan K Alder

Am J Respir Cell Mol Biol· May 2024

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Mammalian Target of Rapamycin Complex 1 Activation in Macrophages Contributes to Persistent Lung Inflammation following Respiratory Tract Viral Infection.
Brydie R Huckestein, Kelly Zeng, Rosemary Westcott, Jonathan K Alder, Danielle Antos

Am J Pathol· March 2024

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Increased expression of CXCL6 in secretory cells drives fibroblast collagen synthesis and is associated with increased mortality in idiopathic pulmonary fibrosis.
Harinath Bahudhanapati, Jiangning Tan, Rosa Marie Apel, Benjamin Seeliger, Jonas Schupp, Jonathan K Alder

Eur Respir J· January 2024

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Human telomere length is chromosome specific and conserved across individuals.
Kayarash Karimian, Aljona Groot, Vienna Huso, Ramin Kahidi, Kar-Tong Tan, Jonathan K Alder

bioRxiv· January 2024

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Impact of age and telomere length on circulating T cells and rejection risk after lung transplantation for idiopathic pulmonary fibrosis.
Mark E Snyder, Michaela R Anderson, Luke J Benvenuto, Rachel M Sutton, Anna Bondonese, Jonathan K Alder

J Heart Lung Transplant· December 2023

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BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary infection.
Rick van der Geest, Hernán F Peñaloza, Zeyu Xiong, Shekina Gonzalez-Ferrer, Xiaojing An, Jonathan K Alder

Am J Physiol Lung Cell Mol Physiol· November 2023

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Lung transplant recipients with telomere-mediated pulmonary fibrosis have increased risk for hematologic complications.
Stefanie J Hannan, Carlo J Iasella, Rachel M Sutton, Iulia D Popescu, Ritchie Koshy, Jonathan K Alder

Am J Transplant· October 2023

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Intact mitochondrial function in the setting of telomere-induced senescence.
Daniel I Sullivan, Fiona M Bello, Agustin Gil Silva, Kevin M Redding, Luca Giordano, Jonathan K Alder

Aging Cell· October 2023

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Down syndrome is associated with altered frequency and functioning of tracheal multiciliated cells, and response to influenza virus infection.
Samantha N Thomas, Brian F Niemeyer, Rocio J Jimenez-Valdes, Alexander J Kaiser, Joaquin M Espinosa, Jonathan K Alder

iScience· August 2023

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Spatial mapping of cellular senescence: emerging challenges and opportunities.
Aditi U Gurkar, Akos A Gerencser, Ana L Mora, Andrew C Nelson, Anru R Zhang, Jonathan K Alder

Nat Aging· July 2023

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Rare surfactant-related variants in familial and sporadic pulmonary fibrosis.
Rachel M Sutton, Humberto Trejo Bittar, Daniel I Sullivan, Agustin Gil Silva, Harinath Bahudhanapati, Jonathan K Alder

Hum Mutat· December 2022

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Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice.
Bingxian Xie, Anjana Murali, Amber M Vandevender, Jeffrey Chen, Agustin Gil Silva, Jonathan K Alder

iScience· December 2022

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Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-α during Acute and Chronic Lung Allograft Rejection.
Antu Das, Xingan Wang, Jianxin Wei, Aki Hoji, Tiffany A Coon, Jonathan K Alder

J Immunol· November 2022

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TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma.
Pattra Chun-On, Angela M Hinchie, Holly C Beale, Agustin A Gil Silva, Elizabeth Rush, Jonathan K Alder

Science· November 2022

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Telomere-mediated lung disease.
Jonathan K Alder, Mary Armanios

Physiol Rev· October 2022

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