Publications by authors named "Jonathan Astin"

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APOA1 binding protein promotes lymphatic cell fate and lymphangiogenesis by relieving caveolae-mediated inhibition of VEGFR3 signaling.
Jun-Dae Kim, Surbhi Chaudhary, Weiqing Chen, Jonathan Astin, Philip S Crosier

Nat Commun· October 2025

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A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity.
Lucia Yi Du, Pramuk Keerthisinghe, Leah Rolland, Yih Jian Sung, Hannah Darroch, Jonathan W Astin

Sci Immunol· May 2025

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The Chemistry of Anticancer Mononuclear and N-Bridged Dinuclear 8-Aminoquinoline Half-sandwich Metal Complexes.
Tasha R Steel, Julia Stjärnhage, Mie Riisom, Hugh O Bloomfield, Caitlin D Herbert, Jonathan W Astin

Chemistry· April 2025

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Biotin functionalization of 8-hydroxyquinoline anticancer organometallics: low toxicity but potent activity.
Tasha R Steel, Julia Stjärnhage, Zexiong Lin, Hugh O Bloomfield, Caitlin D Herbert, Jonathan W Astin

Dalton Trans· January 2025

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Canthin-6-One Inhibits Developmental and Tumour-Associated Angiogenesis in Zebrafish.
Mei Fong Ng, Juliana Da Silva Viana, Pei Jean Tan, Denver D Britto, Sy Bing Choi, Jonathan W Astin

Pharmaceuticals (Basel)· January 2024

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In vitro and in vivo accumulation of the anticancer Ru complexes [Ru(cym)(HQ)Cl] and [Ru(cym)(PCA)Cl]Cl.
Mie Riisom, Stuart J Morrow, Caitlin D Herbert, William D J Tremlett, Jonathan W Astin

J Biol Inorg Chem· December 2023

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Microinjection of β-glucan Into Larval Zebrafish () for the Assessment of a Trained-Like Immunity Phenotype.
Hannah Darroch, Jonathan W Astin, Christopher J Hall

Bio Protoc· December 2023

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Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity.
Hannah Darroch, Pramuk Keerthisinghe, Yih Jian Sung, Leah Rolland, Anneke Prankerd-Gough, Jonathan W Astin

Sci Adv· September 2023

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Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity .
Matthew P Sullivan, Muneebah Adams, Mie Riisom, Caitlin D Herbert, Kelvin K H Tong, Jonathan W Astin

Dalton Trans· January 2023

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Plexin D1 negatively regulates zebrafish lymphatic development.
Denver D Britto, Jia He, June P Misa, Wenxuan Chen, Purvi M Kakadia, Jonathan W Astin

Development· November 2022

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Uricase-Deficient Larval Zebrafish with Elevated Urate Levels Demonstrate Suppressed Acute Inflammatory Response to Monosodium Urate Crystals and Prolonged Crystal Persistence.
Tanja Linnerz, Yih Jian Sung, Leah Rolland, Jonathan W Astin, Nicola Dalbeth

Genes (Basel)· November 2022

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Towards a new model of trained immunity: Exposure to bacteria and β-glucan protects larval zebrafish against subsequent infections.
Hannah Darroch, Jonathan W Astin, Christopher J Hall

Dev Comp Immunol· July 2022

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A New Transgenic Line for Rapid and Complete Neutrophil Ablation.
Christopher J Hall, Jonathan W Astin, Jeff S Mumm, David F Ackerley

Zebrafish· June 2022

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3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish.
Kazuhide S Okuda, Mei Fong Ng, Nur Faizah Ruslan, Neil I Bower, Dedrick Soon Seng Song, Jonathan W Astin

Pharmaceuticals (Basel)· June 2021

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Isolation of Neutrophils from Larval Zebrafish and Their Transplantation into Recipient Larvae for Functional Studies.
Hannah Darroch, Jonathan W Astin, Christopher J Hall

Methods Mol Biol· January 2021

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A Multitargeted Approach: Organorhodium Anticancer Agent Based on Vorinostat as a Potent Histone Deacetylase Inhibitor.
Muhammad Hanif, Jahanzaib Arshad, Jonathan W Astin, Zohaib Rana, Ayesha Zafar

Angew Chem Int Ed Engl· August 2020

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Targeting Drugs to Larval Zebrafish Macrophages by Injecting Drug-Loaded Liposomes.
Tanja Linnerz, Manju Kanamala, Jonathan W Astin, Nicola Dalbeth, Zimei Wu

J Vis Exp· February 2020

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Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways.
Benjamin Stump, Shikshya Shrestha, Anthony M Lamattina, Pierce H Louis, Woohyun Cho, Jonathan Astin

PLoS One· December 2019

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Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity.
Shahida Parveen, Muhammad Hanif, Euphemia Leung, Kelvin K H Tong, Annie Yang, Jonathan Astin

Chem Commun (Camb)· October 2019

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In Vivo Imaging and Quantitation of the Host Angiogenic Response in Zebrafish Tumor Xenografts.
Denver D Britto, Christopher J Hall, Jonathan W Astin

J Vis Exp· August 2019

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Characterization of Zebrafish Facial Lymphatics.
Tiffany C Y Eng, Jonathan W Astin

Methods Mol Biol· May 2019

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Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors.
Tiffany Cy Eng, Wenxuan Chen, Kazuhide S Okuda, June P Misa, Yvonne Padberg, Jonathan W Astin

EMBO Rep· May 2019

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Liposome-Mediated Drug Delivery in Larval Zebrafish to Manipulate Macrophage Function.
Zimei Wu, Ben Koh, Lisa M Lawrence, Manju Kanamala, Bregina Pool, Jonathan W Astin

Zebrafish· April 2019

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Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model.
Denver D Britto, Barbara Wyroba, Wenxuan Chen, Rhoswen A Lockwood, Khanh B Tran, Jonathan W Astin

Dis Model Mech· November 2018

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Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation.
Christopher J Hall, Leslie E Sanderson, Lisa M Lawrence, Bregina Pool, Maarten van der Kroef, Jonathan W Astin

J Clin Invest· May 2018

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