Publications by authors named "Jonathan D Best"

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The Epigenetics of Normal Pregnancy.
Jonathan D Best, Nessa Carey

Obstet Med· March 2013

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Epigenetic therapies for non-oncology indications.
Jonathan D Best, Nessa Carey

Drug Discov Today· December 2010

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Epigenetic opportunities and challenges in cancer.
Jonathan D Best, Nessa Carey

Drug Discov Today· January 2010

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Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.
Linda E Keown, Ian Collins, Laura C Cooper, Timothy Harrison, Andrew Madin, Jonathan D Best

J Med Chem· June 2009

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Non-associative learning in larval zebrafish.
Jonathan D Best, Stéphane Berghmans, Julia J F G Hunt, Samantha C Clarke, Angeleen Fleming

Neuropsychopharmacology· April 2008

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The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.
Jonathan D Best, David W Smith, Michael A Reilly, Ruth O'Donnell, Huw D Lewis

J Pharmacol Exp Ther· February 2007

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A comparative assessment of gamma-secretase activity in transgenic and non-transgenic rodent brain.
Julian L Goggi, Huw D Lewis, Joanie Mok, Tim Harrison, Mark S Shearman, Jonathan D Best

J Neurosci Methods· October 2006

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In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat.
Jonathan D Best, Mark T Jay, Franklin Otu, Ian Churcher, Michael Reilly

J Pharmacol Exp Ther· May 2006

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4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.
Ian Churcher, Dirk Beher, Jonathan D Best, José L Castro, Earl E Clarke

Bioorg Med Chem Lett· January 2006

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Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide].
Jonathan D Best, Mark T Jay, Franklin Otu, Jerome Ma, Alan Nadin

J Pharmacol Exp Ther· May 2005

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A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.
Stephen J Lewis, Adrian L Smith, Joseph G Neduvelil, Graeme I Stevenson, Matthew J Lindon, Jonathan D Best

Bioorg Med Chem Lett· January 2005

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Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells.
Giles E Duffield, Jonathan D Best, Bernhard H Meurers, Anton Bittner, Jennifer J Loros

Curr Biol· April 2002

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