Publications by authors named "Jonathan D Lippiat"

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Identification of New KCNT1-Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling.
Michael G Ricos, Bethan A Cole, Rashid Hussain, Grigori Y Rychkov, Zeeshan Shaukat, Jonathan D Lippiat

Ann Neurol· December 2025

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The mechanosensitive channel YbiO has a conductance equivalent to the largest gated pore.
Benjamin J Lane, Mariangela Dionysopoulou, Nana Yan, Jonathan D Lippiat, Stephen P Muench

Structure· April 2025

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A molecular switch in RCK2 triggers sodium-dependent activation of K1.1 (KCNT1) potassium channels.
Bethan A Cole, Antreas C Kalli, Nadia Pilati, Stephen P Muench, Jonathan D Lippiat

Biophys J· July 2024

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K1.3-induced hyperpolarization is required for efficient Kaposi's sarcoma-associated herpesvirus lytic replication.
Holli Carden, Katherine L Harper, Timothy J Mottram, Oliver Manners, Katie L Allott, Jonathan D Lippiat

Sci Signal· July 2024

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Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy.
Rashid Hussain, Chiao Xin Lim, Zeeshan Shaukat, Anowarul Islam, Emily A Caseley, Jonathan D Lippiat

Sci Rep· February 2024

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Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling.
Moza M Al-Owais, Nishani T Hettiarachchi, Mark L Dallas, Jason L Scragg, Jonathan D Lippiat

Commun Biol· June 2023

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Is intestinal transport dysfunctional in COVID-19-related diarrhea?
Geoffrey I Sandle, Morgan R Herod, Juan Fontana, Jonathan D Lippiat, Peter G Stockley

Am J Physiol Gastrointest Liver Physiol· May 2023

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Author Correction: Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis.
Anna J Higgins, Alex J Flynn, Anaïs Marconnet, Laura J Musgrove, Vincent L G Postis, Jonathan D Lippiat

Commun Biol· January 2022

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Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis.
Anna J Higgins, Alex J Flynn, Anaïs Marconnet, Laura J Musgrove, Vincent L G Postis, Jonathan D Lippiat

Commun Biol· November 2021

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Targeting K1.1 channels in KCNT1-associated epilepsy.
Bethan A Cole, Steven J Clapcote, Stephen P Muench, Jonathan D Lippiat

Trends Pharmacol Sci· August 2021

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Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism.
Faye L Styles, Moza M Al-Owais, Jason L Scragg, Eulashini Chuntharpursat-Bon, Nishani T Hettiarachchi, Jonathan D Lippiat

Cell Death Dis· April 2021

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TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection.
Hayley Pearson, Eleanor J A A Todd, Mareike Ahrends, Samantha E Hover, Adrian Whitehouse, Jonathan D Lippiat

Thorax· January 2021

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Small molecules restore the function of mutant CLC5 associated with Dent disease.
Jingshu Liu, Tal T Sadeh, Jonathan D Lippiat, Rajesh V Thakker, Graeme C Black

J Cell Mol Med· January 2021

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Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated K1.1 (KCNT1) Potassium Channel.
Bethan A Cole, Rachel M Johnson, Hattapark Dejakaisaya, Nadia Pilati, Colin W G Fishwick, Jonathan D Lippiat

iScience· May 2020

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A cytoplasmic Slo3 isoform is expressed in somatic tissues.
Julio C Chávez, Alberto Vicens, David C Wrighton, Karla Andrade-López, Carmen Beltrán, Jonathan D Lippiat

Mol Biol Rep· October 2019

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Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets.
Charalampos Kapsalis, Bolin Wang, Hassane El Mkami, Samantha J Pitt, Jason R Schnell, Jonathan D Lippiat

Nat Commun· October 2019

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Differential patterns of inhibition of the sugar transporters GLUT2, GLUT5 and GLUT7 by flavonoids.
Julia S Gauer, Sarka Tumova, Jonathan D Lippiat, Asimina Kerimi, Gary Williamson

Biochem Pharmacol· June 2018

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The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility.
Gabrielė Stakaitytė, Nnenna Nwogu, Jonathan D Lippiat, G Eric Blair, Krzysztof Poterlowicz

J Biol Chem· March 2018

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Affimer proteins are versatile and renewable affinity reagents.
Christian Tiede, Robert Bedford, Sophie J Heseltine, Gina Smith, Imeshi Wijetunga, Jonathan D Lippiat

Elife· June 2017

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The changing landscape of membrane protein structural biology through developments in electron microscopy.
Shaun Rawson, Simon Davies, Jonathan D Lippiat, Stephen P Muench

Mol Membr Biol· March 2016

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Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium.
David C Wrighton, Stephen P Muench, Jonathan D Lippiat

Br J Pharmacol· September 2015

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Requirement for chloride channel function during the hepatitis C virus life cycle.
Zsofia Igloi, Bjorn-Patrick Mohl, Jonathan D Lippiat, Mark Harris, Jamel Mankouri

J Virol· April 2015

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Conventional micropipette-based patch clamp techniques.
Jonathan D Lippiat, David C Wrighton

Methods Mol Biol· September 2013

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Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor.
Xin Jin, Shihab Shah, Yani Liu, Huiran Zhang, Meredith Lees, Jonathan D Lippiat

Sci Signal· August 2013

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Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients.
Caroline M Gorvin, Martijn J Wilmer, Sian E Piret, Brian Harding, Lambertus P van den Heuvel, Jonathan D Lippiat

Proc Natl Acad Sci U S A· April 2013

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