Publications by authors named "Jonathan Elkins"

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Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK Inhibitors.
Alex G Baldwin, David W Foley, D Heulyn Jones, Hyunah Lee, Ross Collins, Jonathan M Elkins

J Med Chem· August 2025

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Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Claudia Tredup, Suzanne Ackloo, Hartmut Beck, Peter J Brown, Alex N Bullock, Jonathan M Elkins

RSC Med Chem· February 2025

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Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.
Alex G Baldwin, David W Foley, Ross Collins, Hyunah Lee, D Heulyn Jones, Jonathan M Elkins

J Med Chem· January 2025

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A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Lena Münzker, Serah W Kimani, Milan M Fowkes, Aiping Dong, Hong Zheng, Jonathan M Elkins

Commun Biol· July 2024

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Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.
Fernando H de Souza Gama, Luiz A Dutra, Michael Hawgood, Caio Vinícius Dos Reis, Ricardo A M Serafim, Jonathan M Elkins

J Med Chem· June 2024

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Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.
Esra Balıkçı, Anne-Sophie M C Marques, Ludwig G Bauer, Raina Seupel, James Bennett, Jonathan M Elkins

J Med Chem· May 2024

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Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.
Scott H Henderson, Fiona J Sorrell, James M Bennett, Oleg Fedorov, Marcus T Hanley, Jonathan M Elkins

Eur J Med Chem· April 2024

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Recent advances in the structural biology of tyrosine kinases.
Karolina A Rygiel, Jonathan M Elkins

Curr Opin Struct Biol· October 2023

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Updated protein domain annotation of the PARP protein family sheds new light on biological function.
Marcin J Suskiewicz, Deeksha Munnur, Øyvind Strømland, Ji-Chun Yang, Laura E Easton, Jonathan M Elkins

Nucleic Acids Res· August 2023

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An open source plant kinase chemogenomics set.
Maria Florencia Ercoli, Priscila Zonzini Ramos, Rashmi Jain, Joseph Pilotte, Oliver Xiaoou Dong, Jonathan M Elkins

Plant Direct· November 2022

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Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity.
Ross Collins, Hyunah Lee, D Heulyn Jones, Jonathan M Elkins, Jason A Gillespie

J Med Chem· October 2022

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Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery.
Fiona Scott, Angela M Fala, Jessica E Takarada, Mihaela P Ficu, Lewis E Pennicott, Jonathan M Elkins

Bioorg Med Chem Lett· March 2022

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Chemical Probes for Understudied Kinases: Challenges and Opportunities.
Ricardo A M Serafim, Jonathan M Elkins, William J Zuercher, Stefan A Laufer, Matthias Gehringer

J Med Chem· January 2022

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Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
Ricardo A M Serafim, Fiona J Sorrell, Benedict-Tilman Berger, Ross J Collins, Stanley N S Vasconcelos, Jonathan M Elkins

J Med Chem· September 2021

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Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.
Scott H Henderson, Fiona Sorrell, James Bennett, Oleg Fedorov, Marcus T Hanley, Jonathan M Elkins

J Med Chem· August 2021

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Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
Benedict-Tilman Berger, Marta Amaral, Daria B Kokh, Ariane Nunes-Alves, Djordje Musil, Jonathan M Elkins

Cell Chem Biol· May 2021

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Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.
Scott H Henderson, Fiona Sorrell, James Bennett, Marcus T Hanley, Sean Robinson, Jonathan M Elkins

ACS Med Chem Lett· August 2020

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Targeting the Water Network in Cyclin G-Associated Kinase (GAK) with 4-Anilino-quin(az)oline Inhibitors.
Christopher R M Asquith, Graham J Tizzard, James M Bennett, Carrow I Wells, Jonathan M Elkins

ChemMedChem· July 2020

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Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer.
Fiona Scott, Angela M Fala, Lewis E Pennicott, Tristan D Reuillon, Katlin B Massirer, Jonathan M Elkins

Bioorg Med Chem Lett· April 2020

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SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.
Carrow Wells, Rafael M Couñago, Juanita C Limas, Tuanny L Almeida, Jeanette Gowen Cook, Jonathan M Elkins

ACS Med Chem Lett· March 2020

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Design and Analysis of the 4-Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure-Activity Relationships.
Christopher R M Asquith, Tuomo Laitinen, James M Bennett, Carrow I Wells, Jonathan M Elkins

ChemMedChem· January 2020

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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).
Christopher R M Asquith, James M Bennett, Lianyong Su, Tuomo Laitinen, Jonathan M Elkins

Molecules· November 2019

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Binding and structural analyses of potent inhibitors of the human Ca/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.
Gerson S Profeta, Caio V Dos Reis, André da S Santiago, Paulo H C Godoi, Angela M Fala, Jonathan M Elkins

Sci Rep· November 2019

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Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.
Ricardo A M Serafim, Fernando H de Souza Gama, Luiz A Dutra, Caio V Dos Reis, Stanley N S Vasconcelos, Jonathan M Elkins

ACS Med Chem Lett· September 2019

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The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity.
Germanna Lima Righetto, Dev Sriranganadane, Levon Halabelian, Carla G Chiodi, Jonathan M Elkins

Front Plant Sci· September 2019

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