Publications by authors named "Suzanne Ackloo"

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E
Enantioselective protein affinity selection mass spectrometry (E-ASMS).
Xiaoyun Wang, Jianxian Sun, Shabbir Ahmad, Diwen Yang, Fengling Li, Suzanne Ackloo

Nat Commun· December 2025

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Site-Specific Hydrogen Deuterium Exchange Difference Mass Spectrometry Measurements for Ligand Binding.
Joseph Anacleto, Suzanne Ackloo, Cheryl Arrowsmith, Esther Wolf, Yves Leblanc

J Am Soc Mass Spectrom· October 2025

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Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space.
Fuqiang Ban, Rahul Ravichandran, Galen J Correy, Oleksandra Herasymenko, Madhushika Silva, Suzanne Ackloo

bioRxiv· September 2025

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High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin.
Esther Wolf, Rebeka Fanti, Tatsuya Ikenoue, Justin C Deme, Swati Balakrishnan, Suzanne Ackloo

bioRxiv· August 2025

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OICR-41103 as a chemical probe for the DCAF1 WD40 domain.
Serah W Kimani, Mahmoud Noureldin, Brian Wilson, Laurent Hoffer, Stuart R Green, Suzanne Ackloo

Commun Biol· July 2025

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Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities.
Filipp Gusev, Evgeny Gutkin, Francesco Gentile, Fuqiang Ban, S Benjamin Koby, Suzanne Ackloo

J Chem Inf Model· June 2025

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Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS).
Xiaoyun Wang, Jianxian Sun, Shabbir Ahmad, Diwen Yang, Fengling Li, Suzanne Ackloo

bioRxiv· April 2025

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T
The GPCR antagonist PPTN synergizes with caspofungin providing increased fungicidal activity against .
Thaila Fernanda Dos Reis, Endrews Delbaje, Camila Figueiredo Pinzan, Rafael Bastos, Suzanne Ackloo

Microbiol Spectr· March 2025

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Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Claudia Tredup, Suzanne Ackloo, Hartmut Beck, Peter J Brown, Alex N Bullock

RSC Med Chem· February 2025

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Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1.
Akhila Mettu, Marta Glavatskikh, Xiaowen Wang, Antonio Jesús Lara Ordóñez, Fengling Li, Suzanne Ackloo

Chem Sci· February 2025

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Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells.
Mélanie Uguen, Devan J Shell, Madhushika Silva, Yu Deng, Fengling Li, Suzanne Ackloo

Nat Commun· February 2025

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A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins.
Suzanne Ackloo, Fengling Li, Magda Szewczyk, Almagul Seitova, Peter Loppnau

J Med Chem· January 2025

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C
CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein.
Fengling Li, Suzanne Ackloo, Cheryl H Arrowsmith, Fuqiang Ban, Christopher J Barden

J Chem Inf Model· November 2024

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C
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
Mark F Mabanglo, Brian Wilson, Mahmoud Noureldin, Serah W Kimani, Ahmed Mamai, Suzanne Ackloo

Nat Commun· November 2024

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Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells.
Mélanie Uguen, Devan J Shell, Madhushika Silva, Yu Deng, Fengling Li, Suzanne Ackloo

bioRxiv· September 2024

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Quantitative Hydrogen-Deuterium Exchange Mass Spectrometry for Simultaneous Structural Characterization and Affinity Indexing of Single Target Drug Candidate Libraries.
Esther Wolf, Oleksandra Herasymenko, Maria Kutera, Cristina Lento, Cheryl Arrowsmith, Suzanne Ackloo

Anal Chem· August 2024

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Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2.
Merveille Eguida, Guillaume Bret, François Sindt, Fengling Li, Irene Chau, Suzanne Ackloo

J Chem Inf Model· July 2024

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D
Development of Peptide Displacement Assays to Screen for Antagonists of DDB1 Interactions.
Darren Yong, Shabbir Ahmad, Mark F Mabanglo, Levon Halabelian, Matthieu Schapira, Suzanne Ackloo

Biochemistry· May 2024

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Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.
Shabbir Ahmad, Jin Xu, Jianwen A Feng, Ashley Hutchinson, Hong Zeng, Suzanne Ackloo

J Med Chem· December 2023

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D
Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6.
Rachel J Harding, Ivan Franzoni, Mandeep K Mann, Magdalena M Szewczyk, Bijan Mirabi, Suzanne Ackloo

J Med Chem· August 2023

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SETDB1 Triple Tudor Domain Ligand, (,)-59, Promotes Methylation of Akt1 in Cells.
Mélanie Uguen, Yu Deng, Fengling Li, Devan J Shell, Jacqueline L Norris-Drouin, Suzanne Ackloo

ACS Chem Biol· August 2023

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Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets.
Serah W Kimani, Julie Owen, Stuart R Green, Fengling Li, Yanjun Li, Suzanne Ackloo

J Chem Inf Model· July 2023

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Target 2035 - an update on private sector contributions.
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex Bullock

RSC Med Chem· June 2023

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SETDB1 Triple Tudor Domain Ligand, ( )-59, Promotes Methylation of Akt1 in Cells.
Mélanie Uguen, Yu Deng, Fengling Li, Devan J Shell, Jacqueline L Norris-Drouin, Suzanne Ackloo

bioRxiv· May 2023

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A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi.
Thaila Fernanda Dos Reis, Patrícia Alves de Castro, Rafael Wesley Bastos, Camila Figueiredo Pinzan, Pedro F N Souza, Suzanne Ackloo

Nat Commun· April 2023

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