Publications by authors named "Jonathan Karn"

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Non-neutralizing antibodies against SARS-CoV-2 nucleocapsid protein mediate variant transcendent antibody-dependent cellular cytotoxicity.
Anthonia E Osuagwu, Michael Payne, Jürgen Bosch, Uri Mbonye, Kien Nguyen, Jonathan Karn

J Immunol· December 2025

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Interleukin-2 is a potent latency reversal agent in people with treated HIV-1.
Michael L Freeman, Brian M Clagett, Konstantin Leskov, Daniela Moisi, George A Yendewa, Jonathan Karn

Sci Adv· December 2025

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HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency.
Leah M Plasek Hegde, Lalith S Gunawardane, Farshad Niazi, Uri Mbonye, Konstantin Leskov, Jonathan Karn

Nat Microbiol· October 2025

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HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways.
Sara J Mason, Sheetal Sreeram, Farshad Niazi, Konstantin Leskov, Alan D Levine, Jonathan Karn

bioRxiv· May 2025

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Cytokine trajectory over time in men and women with HIV on long-term antiretroviral therapy.
Christophe Vanpouille, Alan Wells, Victor DeGruttola, Miranda Lynch, Xinlian Zhang, Jonathan Karn

AIDS· January 2025

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Protocol for intracellular immunofluorescence measurements of latent HIV reactivation in a primary CD4 T cell model.
Uri Mbonye, Anna Agaponova, Muda Yang, Jonathan Karn

STAR Protoc· December 2024

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The sounds of silencing: dynamic epigenetic control of HIV latency.
Kien Nguyen, Jonathan Karn

Curr Opin HIV AIDS· May 2024

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Direct Analysis of HIV mRNA mA Methylation by Nanopore Sequencing.
Ethan Honeycutt, Fredrick Kizito, Jonathan Karn, Thomas Sweet

Methods Mol Biol· May 2024

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The cell biology of HIV-1 latency and rebound.
Uri Mbonye, Jonathan Karn

Retrovirology· April 2024

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Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation.
Fredrick Kizito, Kien Nguyen, Uri Mbonye, Meenakshi Shukla, Benjamin Luttge, Jonathan Karn

Proc Natl Acad Sci U S A· April 2024

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Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells.
Harpreet Kaur, Paige Minchella, David Alvarez-Carbonell, Neeraja Purandare, Vijay K Nagampalli, Jonathan Karn

Int J Mol Sci· July 2023

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Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary.
Brigitte E Sanders-Beer, Nancie M Archin, Zabrina L Brumme, Michael P Busch, Claire Deleage, Jonathan Karn

AIDS Res Hum Retroviruses· June 2023

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A viral pan-end RNA element and host complex define a SARS-CoV-2 regulon.
Debjit Khan, Fulvia Terenzi, GuanQun Liu, Prabar K Ghosh, Fengchun Ye, Jonathan Karn

Nat Commun· June 2023

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Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains.
Mona Rheinberger, Ana Luisa Costa, Martin Kampmann, Dunja Glavas, Iart Luca Shytaj, Jonathan Karn

Cell Rep· February 2023

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New insights into transcription elongation control of HIV-1 latency and rebound.
Uri Mbonye, Fredrick Kizito, Jonathan Karn

Trends Immunol· January 2023

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COVID-19 plasma exosomes promote proinflammatory immune responses in peripheral blood mononuclear cells.
Lechuang Chen, Rui Chen, Min Yao, Zhimin Feng, Guoxiang Yuan, Jonathan Karn

Sci Rep· December 2022

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Impact of Tamoxifen on Vorinostat-Induced Human Immunodeficiency Virus Expression in Women on Antiretroviral Therapy: AIDS Clinical Trials Group A5366, The MOXIE Trial.
Eileen P Scully, Evgenia Aga, Athe Tsibris, Nancie Archin, Kate Starr, Jonathan Karn

Clin Infect Dis· October 2022

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The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder.
Sheetal Sreeram, Fengchun Ye, Yoelvis Garcia-Mesa, Kien Nguyen, Ahmed El Sayed, Jonathan Karn

Trends Immunol· August 2022

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Detecting Sources of Immune Activation and Viral Rebound in HIV Infection.
Stephen W Wietgrefe, Lijie Duan, Jodi Anderson, Guillermo Marqués, Mark Sanders, Jonathan Karn

J Virol· August 2022

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Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells.
Fengchun Ye, David Alvarez-Carbonell, Kien Nguyen, Konstantin Leskov, Yoelvis Garcia-Mesa, Jonathan Karn

PLoS Pathog· July 2022

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A Reliable Primary Cell Model for HIV Latency: The QUECEL (Quiescent Effector Cell Latency) Method.
Meenakshi Shukla, Fredrick Kizito, Uri Mbonye, Kien Nguyen, Curtis Dobrowolski, Jonathan Karn

Methods Mol Biol· March 2022

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Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial.
Jeffrey S Miller, Zachary B Davis, Erika Helgeson, Cavan Reilly, Ann Thorkelson, Jonathan Karn

Nat Med· February 2022

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A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung Cells.
Abhijit Basu, Srinivasa Penumutchu, Kien Nguyen, Uri Mbonye, Blanton S Tolbert, Jonathan Karn

J Virol· January 2022

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Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda.
Samira Joussef-Piña, Immaculate Nankya, Sophie Nalukwago, Joy Baseke, Sandra Rwambuya, Jonathan Karn

Retrovirology· January 2022

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Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation.
Kien Nguyen, Curtis Dobrowolski, Meenakshi Shukla, Won-Kyung Cho, Benjamin Luttge, Jonathan Karn

PLoS Pathog· October 2021

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