Publications by authors named "Jonathan S Marchant"

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Novel 1-1,2,3-Triazole Derivatives of Praziquantel with TRPM Modulatory Activity and Antiparasitic Effects on Larvae, Juvenile, and Adult Worms of .
Floriano Paes Silva Junior, Rafael Ferreira Dantas, Sang-Kyu Park, Helen Whiteland, Camilla Thomaz da Silva Oliveira, Jonathan S Marchant

ACS Infect Dis· December 2025

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Target-Based Design of Praziquantel Analogs at Cestode TRPM.
Daniel J Sprague, Sang-Kyu Park, Marc Kaethner, Claudia M Rohr, Mina R Ghobrial, Jonathan S Marchant

ACS Infect Dis· September 2025

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TRPtracker: a community database for monitoring praziquantel sensitivity at TRPM variants.
Claudia M Rohr, Sang-Kyu Park, Kelsilandia Aguiar-Martins, Timothy J C Anderson, Duncan J Berger, Jonathan S Marchant

bioRxiv· August 2025

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NAADP signaling: Master manipulation.
Qianru Mu, Jade L Harris, David I Yule, James T Slama, Jonathan S Marchant

Cell Calcium· December 2024

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Target-based discovery of a broad-spectrum flukicide.
Daniel J Sprague, Sang-Kyu Park, Svenja Gramberg, Lisa Bauer, Claudia M Rohr, Jonathan S Marchant

Nat Struct Mol Biol· September 2024

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Extensive transmission and variation in a functional receptor for praziquantel resistance in endemic .
Duncan J Berger, Sang-Kyu Park, Thomas Crellen, Tushabe John Vianney, Narcis B Kabatereine, Jonathan S Marchant

bioRxiv· September 2024

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Diazirine-AIOC-NAADP, a Clickable-Photoactive NAADP Analog for Sea Urchin NAADP Binding Proteins.
Yuqing Zhang, Zhong Guan, Jennifer N Gadient, Sushil Kumar, Gihan Gunaratne, Jonathan S Marchant

ACS Chem Biol· August 2024

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Progress interrogating TRPMPZQ as the target of praziquantel.
Jonathan S Marchant

PLoS Negl Trop Dis· February 2024

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TRP drop, TRP drop: a steady patter of anti-schistosomal target illumination.
Daniel J Sprague, Claudia M Rohr, Jonathan S Marchant

Front Parasitol· February 2024

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The anthelmintic meclonazepam activates a schistosome transient receptor potential channel.
Sang-Kyu Park, Daniel J Sprague, Claudia M Rohr, Evgeny G Chulkov, Ian Petrow, Jonathan S Marchant

J Biol Chem· January 2024

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Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca signals between lysosomes and the endoplasmic reticulum.
Yu Yuan, Vikas Arige, Ryo Saito, Qianru Mu, Gabriela C Brailoiu, Jonathan S Marchant

Cell Rep· January 2024

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Progesterone receptor membrane component 1 facilitates Ca signal amplification between endosomes and the endoplasmic reticulum.
Gihan S Gunaratne, Sushil Kumar, Yaping Lin-Moshier, James T Slama, Eugen Brailoiu, Jonathan S Marchant

J Biol Chem· December 2023

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The Anthelmintic Activity of Praziquantel Analogs Correlates with Structure-Activity Relationships at TRPM Orthologs.
Daniel J Sprague, Marc Kaethner, Sang-Kyu Park, Claudia M Rohr, Jade L Harris, Jonathan S Marchant

ACS Med Chem Lett· November 2023

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Praziquantel activates a native cation current in .
Evgeny G Chulkov, Claudia M Rohr, Jonathan S Marchant

Front Parasitol· November 2023

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Metabolism of (R)-Praziquantel versus the Activation of a Parasite Transient Receptor Potential Melastatin Ion Channel.
Lukas Friedrich, Sang-Kyu Park, Peter Ballard, Tobias Hyun Ho Baeurle, David Maillard, Jonathan S Marchant

ChemMedChem· September 2023

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Target-based discovery of a broad spectrum flukicide.
Daniel J Sprague, Sang-Kyu Park, Svenja Gramberg, Lisa Bauer, Claudia M Rohr, Jonathan S Marchant

bioRxiv· September 2023

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Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12.
Gihan S Gunaratne, Eugen Brailoiu, Sushil Kumar, Yu Yuan, James T Slama, Jonathan S Marchant

Sci Signal· August 2023

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Convergent activation of Ca permeability in two-pore channel 2 through distinct molecular routes.
Ryo Saito, Qianru Mu, Yu Yuan, Marcos Rubio-Alarcón, Maria Eznarriaga, Jonathan S Marchant

Sci Signal· August 2023

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Use the force, fluke: Ligand-independent gating of Schistosoma mansoni ion channel TRPM.
Evgeny G Chulkov, Elena Isaeva, Cheryl L Stucky, Jonathan S Marchant

Int J Parasitol· July 2023

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Electrophysiological characterization of a schistosome transient receptor potential channel activated by praziquantel.
Evgeny G Chulkov, Oleg Palygin, Nawal A Yahya, Sang-Kyu Park, Jonathan S Marchant

Int J Parasitol· July 2023

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Vitamin C transport in neurons and epithelia is regulated by secretory carrier-associated membrane protein-2 (SCAMP2).
Mohammad A Rashid, Yaping Lin-Moshier, Gihan S Gunaratne, Sreya Subramanian, Jonathan S Marchant

Int J Biol Macromol· March 2023

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Molecular and cellular basis of praziquantel action in the cardiovascular system.
Nawal A Yahya, Janelle K Lanham, Daniel J Sprague, Oleg Palygin, John D McCorvy, Jonathan S Marchant

Am J Physiol Cell Physiol· February 2023

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Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity.
Claudia M Rohr, Daniel J Sprague, Sang-Kyu Park, Nicholas J Malcolm, Jonathan S Marchant

Proc Natl Acad Sci U S A· January 2023

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Synthesis and biological evaluation of novel photo-clickable adenosine and cyclic ADP-ribose analogs: 8-N-2'-O-propargyladenosine and 8-N-2'-O-propargyl-cADPR.
Divya Andy, Gihan S Gunaratne, Jonathan S Marchant, Timothy F Walseth, James T Slama

Bioorg Med Chem· December 2022

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Quantal leaps in understanding Ca signaling: A "Taylored" approach.
Sandip Patel, Martin D Bootman, Ana Rossi, Taufiq Rahman, Jonathan S Marchant

Sci Signal· November 2022

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