Publications by authors named "Jonathan Watts"

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TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.
Brian J Joseph, Kelly A Marshall, Peter Harley, Jacob R Mann, Francesco Alessandrini, Jonathan K Watts

Nat Neurosci· December 2025

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Pervasive noise in human splice site selection.
Eraj S Khokhar, Kaitlyn Brokaw, Zachary J Kartje, Valeria Sanabria, Nida Javeed, Jonathan K Watts

bioRxiv· July 2025

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Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series.
Neil A Shneider, Matthew B Harms, Vlad A Korobeynikov, Olivia M Rifai, Benjamin N Hoover, Jonathan K Watts

Lancet· June 2025

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Identifying optimal conditions for precise knock-in of exogenous DNA into the zebrafish genome.
Sarah Oikemus, Kai Hu, Masahiro Shin, Feston Idrizi, Aliece Goodman-Khan, Jonathan K Watts

Development· June 2025

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Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.
Jarryd M Campbell, Derek M Korpela, Hesong Han, Sheng Zhao, Dennis A Webster, Jonathan K Watts

bioRxiv· June 2025

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Increasing intracellular dNTP levels improves prime editing efficiency.
Pengpeng Liu, Karthikeyan Ponnienselvan, Thomas Nyalile, Sarah Oikemus, Anya T Joynt, Jonathan K Watts

Nat Biotechnol· April 2025

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The N=1 Collaborative: advancing customized nucleic acid therapies through collaboration and data sharing.
Jillian Belgrad, Erin McConnell, Stef Leonard, Nicole Nolen, Marlen C Lauffer, Jonathan K Watts

Nucleic Acids Res· April 2025

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CASCADES, a novel SOX2 super-enhancer-associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma.
Uswa Shahzad, Marina Nikolopoulos, Christopher Li, Michael Johnston, Jenny J Wang, Jonathan K Watts

Mol Oncol· March 2025

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Next generation APOBEC3 inhibitors: optimally designed for potency and nuclease stability.
Adam K Hedger, Wazo Myint, Jeong Min Lee, Diego Suchenski Loustaunau, Vanivilasini Balachandran, Jonathan K Watts

Nucleic Acids Res· March 2025

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Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system.
Michael P Moazami, Julia M Rembetsy-Brown, Samantha L Sarli, Holly R McEachern, Feng Wang, Jonathan K Watts

Mol Ther· December 2024

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Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca and Mg in the formulation.
Rachael Miller, Joseph Paquette, Alexandra Barker, Ellen Sapp, Nicholas McHugh, Jonathan Watts

Mol Ther Nucleic Acids· December 2024

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Efficient convergent synthesis of 1,3-diazepinone nucleosides by ring-closing metathesis and direct glycosylation.
Adam K Hedger, Jonathan Findell, Dinesh S Barak, Celia A Schiffer, Jonathan K Watts

RSC Adv· November 2024

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Next generation APOBEC3 inhibitors: Optimally designed for potency and nuclease stability.
Adam K Hedger, Wazo Myint, Jeong Min Lee, Diego Suchenski-Loustaunau, Vanivilasini Balachandran, Jonathan K Watts

bioRxiv· September 2024

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Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates.
Bin Liu, Xiaolong Dong, Chunwei Zheng, David Keener, Zexiang Chen, Jonathan K Watts

Nat Biotechnol· July 2024

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Avian influenza viruses in New Zealand wild birds, with an emphasis on subtypes H5 and H7: Their distinctive epidemiology and genomic properties.
Wlodek L Stanislawek, Toni Tana, Thomas G Rawdon, Susan C Cork, Kylie Chen, Jonathan Watts

PLoS One· June 2024

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Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca and Mg in the formulation.
Rachael Miller, Joseph Paquette, Alexandra Barker, Ellen Sapp, Nicholas McHugh, Jonathan Watts

bioRxiv· June 2024

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A combinatorial approach for achieving CNS-selective RNAi.
Chantal M Ferguson, Bruno M D C Godinho, Dimas Echeverria, Matthew Hassler, Lorenc Vangjeli, Jonathan Watts

Nucleic Acids Res· May 2024

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Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.
Samantha L Sarli, Hassan H Fakih, Karen Kelly, Gitali Devi, Julia M Rembetsy-Brown, Jonathan K Watts

Nucleic Acids Res· May 2024

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Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope.
Nathan Bamidele, Han Zhang, Xiaolong Dong, Haoyang Cheng, Nicholas Gaston, Jonathan K Watts

Nat Commun· February 2024

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EZH2 inhibition reactivates epigenetically silenced and normalizes molecular and electrophysiological abnormalities in fragile X syndrome neurons.
Minggang Fang, Sara K Deibler, Pranathi Meda Krishnamurthy, Feng Wang, Paola Rodriguez, Jonathan K Watts

Front Neurosci· February 2024

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Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.
Han Zhang, Karen Kelly, Jonathan Lee, Dimas Echeverria, David Cooper, Jonathan K Watts

Nucleic Acids Res· January 2024

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Prime Editing by Lipid Nanoparticle Co-delivery of Chemically Modified pegRNA and Prime Editor mRNA.
Zexiang Chen, Karen Kelly, Haoyang Cheng, Xiaolong Dong, Adam K Hedger, Jonathan K Watts

GEN Biotechnol· December 2023

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Dendritic amphiphilic siRNA: Selective albumin binding, efficacy, and low toxicity.
Hassan H Fakih, Qi Tang, Ashley Summers, Minwook Shin, Julianna E Buchwald, Jonathan K Watts

Mol Ther Nucleic Acids· December 2023

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A Fluorescent Reporter Mouse for Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors.
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Jonathan K Watts

CRISPR J· December 2023

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Addressing the dNTP bottleneck restricting prime editing activity.
Karthikeyan Ponnienselvan, Pengpeng Liu, Thomas Nyalile, Sarah Oikemus, Anya T Joynt, Jonathan K Watts

bioRxiv· October 2023

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