Publications by authors named "Jong Kil Lee"

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Anti-Photoaging Effects of a Standardized Hot Water Extract of Leaves in Ultraviolet B-Exposed Hairless Mice.
Hyeon-A Song, Min-Ji Park, Chae-Won Lee, Sangsu Park, Jong Kil Lee, Kyung-Tae Lee

Pharmaceuticals (Basel)· October 2025

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Korean Red Ginseng Marc-Derived Gintonin Improves Alzheimer's Cognitive Dysfunction by Upregulating LPAR1.
Yujeong Ha, Rami Lee, Seung Ho Jeon, Ji-Hun Kim, Hyo-Sung Jo, Jong Kil Lee

Am J Chin Med· May 2025

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Korean black ginseng extract alleviates Alzheimer's disease-related cognitive impairment by activating the Nrf2/HO-1 pathway and suppressing the p38 MAPK/NF-κB/STAT3 pathways and NLRP3 inflammasome via TLR2 and TLR4 modulation.
Yujeong Ha, Hyo-Sung Jo, Tae Woo Kwon, Seung Ho Jeon, Sang-Kwan Moon, Jong Kil Lee

J Ginseng Res· May 2025

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In vitro and in vivo anti-inflammatory effects of 5-hydroxyconiferaldehyde via NF-κB, MAPK/AP-1, and Nrf2 modulation.
Soo-Yeon Kim, Jae-Min Kim, Kyung-Sook Chung, Dae Sik Jang, Ja-Yeon Lee, Jae Yeol Lee, Jong Kil Lee, Kyung-Tae Lee

Chem Biol Interact· March 2025

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Immunomodulatory Effects of a Standardized Botanical Mixture Comprising Roots and Flowers Through the TLR2/6 Pathway in RAW 264.7 Macrophages and Cyclophosphamide-Induced Immunosuppression Mice.
Seo-Yun Jang, Hyeon-A Song, Min-Ji Park, Kyung-Sook Chung, Jong Kil Lee, Kyung-Tae Lee

Pharmaceuticals (Basel)· February 2025

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Immunostimulation Signaling via Toll-like Receptor 2 Activation: A Molecular Mechanism of OTG1204 In Vitro and In Vivo.
Hyeon-A Song, Seo-Yun Jang, Min-Ji Park, Seung Wook Kim, Choon Gil Kang, Joo Hyun Lee, Jong Kil Lee, Kyung-Tae Lee

Nutrients· October 2024

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Synthesis and biological evaluation of O-benzyl-hispidol derivatives and analogs as dual monoamine oxidase-B inhibitors and anti-neuroinflammatory agents.
Ahmed H E Hassan, Yeonwoo Choi, Rium Kim, Hyeon Jeong Kim, Aya M Almatary, Yeongae Lee, Jong Kil Lee, Yong Sup Lee

Bioorg Med Chem· August 2024

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Anti-obesity effects of a standardized ethanol extract of by regulating the AMPK signaling pathway in 3T3-L1 cells and HFD-induced mice.
Young-Seo Yoon, Kyung-Sook Chung, Su-Yeon Lee, So-Won Heo, Ye-Rin Kim, Jong Kil Lee, Kyung-Tae Lee

Food Funct· June 2024

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Survivin enhances hippocampal neurogenesis and cognitive function in Alzheimer's disease mouse model.
Yeongae Lee, Yeon-Joo Ju, Min Sung Gee, Seung Ho Jeon, Namkwon Kim, Jong Kil Lee

CNS Neurosci Ther· April 2024

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CRISPR base editing-mediated correction of a tau mutation rescues cognitive decline in a mouse model of tauopathy.
Min Sung Gee, Eunji Kwon, Myeong-Hoon Song, Seung Ho Jeon, Namkwon Kim, Jong Kil Lee

Transl Neurodegener· April 2024

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Dextran sodium sulfate (DSS)-induced colitis is alleviated in mice after administration of flavone-derived NRF2-activating molecules.
Nu-Ri Yeon, Jae Seok Cho, Hyung-Seok Yoo, Seung Ho Jeon, Chae-Min Yi, Yun-Seok Lee, Jong Kil Lee

Life Sci· March 2024

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Protective effect of hydrangenol on lipopolysaccharide-induced endotoxemia by suppressing intestinal inflammation.
Seo-Yun Jang, Su-Yeon Kim, Hyeon-A Song, Hyeyun Kim, Kyung-Sook Chung, Jong Kil Lee, Kyung-Tae Lee

Int Immunopharmacol· December 2023

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Inhibition of microfold cells ameliorates early pathological phenotypes by modulating microglial functions in Alzheimer's disease mouse model.
Namkwon Kim, In Gyoung Ju, Seung Ho Jeon, Yeongae Lee, Min-Ji Jung, Lee Ann Garrett-Sinha, Jong Kil Lee

J Neuroinflammation· November 2023

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Eugenol relieves the pathological manifestations of Alzheimer's disease in 5×FAD mice.
Min-Ji Jung, Namkwon Kim, Seung Ho Jeon, Min Sung Gee, Ji-Woon Kim, Jong Kil Lee

Phytomedicine· September 2023

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Aerial part of Houttuynia cordata reverses memory impairment by regulating amyloid beta accumulation and neuroinflammation in Alzheimer's disease model.
In Gyoung Ju, Seungmin Lee, Jin Gyu Choi, Namkwon Kim, Eugene Huh, Jong Kil Lee

Phytother Res· July 2023

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Hydrangenol, an active constituent of (Thunb.) Ser., ameliorates colitis through suppression of macrophage-mediated inflammation in dextran sulfate sodium-treated mice.
Su-Yeon Kim, Kyung-Sook Chung, Seo-Yun Jang, Hee-Soo Han, So-Won Heo, Jong Kil Lee, Sun Hee Lee, Kyung-Tae Lee

Food Funct· July 2023

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Synthesis and Biological Evaluation of -Aminoalkyl-Hispidol Analogs as Multifunctional Monoamine Oxidase-B Inhibitors towards Management of Neurodegenerative Diseases.
Ahmed H E Hassan, Hyeon Jeong Kim, Keontae Park, Yeonwoo Choi, Suyeon Moon, Chae Hyeon Lee, Danbi Lee, Jong Kil Lee, Yong Sup Lee

Antioxidants (Basel)· April 2023

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Chemical Knockdown of Phosphorylated p38 Mitogen-Activated Protein Kinase (MAPK) as a Novel Approach for the Treatment of Alzheimer's Disease.
Seung Hwan Son, Na-Rae Lee, Min Sung Gee, Chae Won Song, Soo Jin Lee, Sang-Kyung Lee, Yoonji Lee, Jong Kil Lee

ACS Cent Sci· March 2023

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3',4'-Dihydroxyflavone mitigates inflammatory responses by inhibiting LPS and TLR4/MD2 interaction.
Hwi-Ho Lee, Ji-Sun Shin, Kyung-Sook Chung, Jae-Min Kim, Seang-Hwan Jung, Jong Kil Lee, Sangmin Lee, Kyung-Tae Lee

Phytomedicine· January 2023

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Positional scanning of natural product hispidol's ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases.
Ahmed H E Hassan, Hyeon Jeong Kim, Min Sung Gee, Jong-Hyun Park, Hye Rim Jeon, Cheol Jung Lee, Danbi Lee, Jong Kil Lee, Yong Sup Lee

J Enzyme Inhib Med Chem· December 2022

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A Botanical Mixture Consisting of and Relieves Obesity via the AMPK Signaling Pathway in 3T3-L1 Adipocytes and HFD-Fed Obese Mice.
Su-Yeon Lee, Kyung-Sook Chung, So-Ri Son, So Young Lee, Dae Sik Jang, Jong-Kil Lee, Sun-Hee Lee, Kyung-Tae Lee

Nutrients· September 2022

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Hesperidin Improves Memory Function by Enhancing Neurogenesis in a Mouse Model of Alzheimer's Disease.
Danbi Lee, Namkwon Kim, Seung Ho Jeon, Min Sung Gee, Yeon-Joo Ju, Yeongae Lee, Sangmin Lee, Jong Kil Lee

Nutrients· July 2022

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Beneficial Activities of Extract in a Western Diet-Induced Murine Non-Alcoholic Steatohepatitis and Related Fibrosis Model via Regulation of the Hepatic Adiponectin and Farnesoid X Receptor Pathways.
Seung Ho Jeon, Eungyeong Jang, Geonha Park, Yeongae Lee, Young Pyo Jang, Kyung-Tae Lee, Jong Kil Lee, Jang-Hoon Lee

Nutrients· February 2022

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Transplantation of gut microbiota derived from Alzheimer's disease mouse model impairs memory function and neurogenesis in C57BL/6 mice.
Namkwon Kim, Seung Ho Jeon, In Gyoung Ju, Min Sung Gee, Jimin Do, Jong Kil Lee

Brain Behav Immun· November 2021

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Identification of ortho catechol-containing isoflavone as a privileged scaffold that directly prevents the aggregation of both amyloid β plaques and tau-mediated neurofibrillary tangles and its in vivo evaluation.
Seung Hwan Son, Ji Min Do, Ji-Na Yoo, Hyun Woo Lee, Nam Kwon Kim, Jong Kil Lee

Bioorg Chem· August 2021

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