Publications by authors named "Jorg Hendle"

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Discovery and clinical translation of ceperognastat, an O-GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease.
William Kielbasa, Paul Goldsmith, Kevin B Donnelly, Hugh N Nuthall, Sergey Shcherbinin, Jörg Hendle

Alzheimers Dement (N Y)· December 2024

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Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nuria Diaz, Carlos Perez, Ana Maria Escribano, Gema Sanz, Julian Priego, Jörg Hendle

Nature· May 2024

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Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA.
Timothy C Cheung, Shane Atwell, Lisa Bafetti, Paulina Delgado Cuenca, Karen Froning, Jorg Hendle

Structure· August 2023

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LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants.
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Jörg Hendle

Cell Rep· May 2022

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LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants.
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Jörg Hendle

bioRxiv· March 2022

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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
David L McKinzie, Leonard L Winneroski, Steven J Green, Erik J Hembre, Jon A Erickson, Jörg Hendle

J Med Chem· June 2021

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The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates.
Bryan E Jones, Patricia L Brown-Augsburger, Kizzmekia S Corbett, Kathryn Westendorf, Julian Davies, Jorg Hendle

Sci Transl Med· May 2021

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LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection.
Bryan E Jones, Patricia L Brown-Augsburger, Kizzmekia S Corbett, Kathryn Westendorf, Julian Davies, Jorg Hendle

bioRxiv· October 2020

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Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Leonard L Winneroski, Jon A Erickson, Steven J Green, Jose E Lopez, Stephanie L Stout, Jörg Hendle

Bioorg Med Chem· January 2020

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Idea2Data: Toward a New Paradigm for Drug Discovery.
Christos A Nicolaou, Christine Humblet, Hong Hu, Eva M Martin, Frank C Dorsey, Jorg Hendle

ACS Med Chem Lett· March 2019

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Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.
Paul D Adams, Kathleen Aertgeerts, Cary Bauer, Jeffrey A Bell, Helen M Berman, Jorg Hendle

Structure· April 2016

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Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Shane Atwell, Christie G Brouillette, Kris Conners, Spencer Emtage, Tarun Gheyi, Jorg Hendle

Protein Eng Des Sel· May 2010

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SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Sean G Buchanan, Jorg Hendle, Patrick S Lee, Christopher R Smith, Pierre-Yves Bounaud

Mol Cancer Ther· December 2009

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Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.
Stephen S Antonysamy, Brandon Aubol, Jeff Blaney, Michelle F Browner, Anthony M Giannetti, Jörg Hendle

Bioorg Med Chem Lett· May 2008

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A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
Shane Atwell, Jason M Adams, John Badger, Michelle D Buchanan, Ingeborg K Feil, Jörg Hendle

J Biol Chem· December 2004

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The 1.59 A resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima.
Frances Park, Ketan Gajiwala, Brian Noland, Lydia Wu, Dongmei He, Jorg Hendle

Proteins· May 2004

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Crystal structure of YIGZ, a conserved hypothetical protein from Escherichia coli k12 with a novel fold.
Frances Park, Ketan Gajiwala, Galina Eroshkina, Eva Furlong, Dongmei He, Jorg Hendle

Proteins· May 2004

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X-ray crystallographic characterization and phasing of an NtrC homologue.
László Sallai, Jörg Hendle, Paul A Tucker

Acta Crystallogr D Biol Crystallogr· September 2003

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Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme.
Brian W Noland, Janet M Newman, Jörg Hendle, John Badger, Jon A Christopher

Structure· November 2002

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Reliable quality-control methods for protein crystal structures.
John Badger, Jörg Hendle

Acta Crystallogr D Biol Crystallogr· February 2002

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