Publications by authors named "Jorge Moscat"

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Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer.
Kosuke Iwane, Yuki Nakanishi, Yu Muta, Jiayu Chen, Kento Yasumura, Jorge Moscat

Nat Commun· November 2025

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Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer.
Laura Antonucci, Na Li, Angeles Duran, Isidoro Cobo, Chiara Nicoletti, Jorge Moscat

Nat Cancer· July 2025

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Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion.
Maria T Diaz-Meco, Juan F Linares, Jorge Moscat

Mol Cell· April 2025

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Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma.
Sadaaki Nishimura, Juan F Linares, Antoine L'Hermitte, Angeles Duran, Tania Cid-Diaz, Jorge Moscat

Mol Cell· December 2024

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Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer.
Shankha S Chatterjee, Juan F Linares, Tania Cid-Diaz, Angeles Duran, Mohd Imran K Khan, Jorge Moscat

Nat Commun· November 2024

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Protocol to characterize mouse intestinal epithelial cell lineage using Opal multiplex immunofluorescence.
Anxo Martinez-Ordoñez, Hiroto Kinoshita, Tania Cid-Diaz, Angeles Duran, Marta Osrodek, Jorge Moscat

STAR Protoc· September 2024

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Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation.
Hiroto Kinoshita, Anxo Martinez-Ordoñez, Tania Cid-Diaz, Qixiu Han, Angeles Duran, Jorge Moscat

Dev Cell· August 2024

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Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Yu Muta, Juan F Linares, Anxo Martinez-Ordoñez, Angeles Duran, Tania Cid-Diaz, Jorge Moscat

Nat Commun· December 2023

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THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer.
Mayuki Omatsu, Yuki Nakanishi, Kosuke Iwane, Naoki Aoyama, Angeles Duran, Jorge Moscat

Nat Commun· September 2023

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Sessile serrated lesions with dysplasia: is it possible to nip them in the bud?
Takahiro Utsumi, Yosuke Yamada, Maria Teresa Diaz-Meco, Jorge Moscat, Yuki Nakanishi

J Gastroenterol· August 2023

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Whole-mount staining of mouse colorectal cancer organoids and fibroblast-organoid co-cultures.
Anxo Martinez-Ordoñez, Tania Cid-Diaz, Angeles Duran, Qixiu Han, Jorge Moscat

STAR Protoc· April 2023

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Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer.
Anxo Martinez-Ordoñez, Angeles Duran, Marc Ruiz-Martinez, Tania Cid-Diaz, Xiao Zhang, Jorge Moscat

Cancer Cell· February 2023

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Protein kinase Cλ/ι in cancer: a contextual balance of time and signals.
Jorge Moscat, Juan F Linares, Angeles Duran, Maria T Diaz-Meco

Trends Cell Biol· December 2022

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Air-liquid organotypic assays to investigate cellular crosstalk in the tumor microenvironment of cancer cells.
Tania Cid-Diaz, Andrea C Lodeiro, Angeles Duran, Jorge Moscat, Maria T Diaz-Meco

STAR Protoc· September 2022

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The lactate-NAD axis activates cancer-associated fibroblasts by downregulating p62.
Juan F Linares, Tania Cid-Diaz, Angeles Duran, Marta Osrodek, Anxo Martinez-Ordoñez, Jorge Moscat

Cell Rep· May 2022

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S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia.
Chang-Ki Oh, Nima Dolatabadi, Piotr Cieplak, Maria T Diaz-Meco, Jorge Moscat

J Neurosci· April 2022

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Immunosurveillance, interferon, and autophagic networking in cancer: the PRKCI-ULK2 paradigm.
Jorge Moscat, Ana Maria Cuervo, Maria T Diaz-Meco

Autophagy· January 2022

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PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Juan F Linares, Xiao Zhang, Anxo Martinez-Ordoñez, Angeles Duran, Hiroto Kinoshita, Jorge Moscat

Mol Cell· November 2021

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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.
Hua Su, Fei Yang, Rao Fu, Xin Li, Randall French, Jorge Moscat

Cancer Cell· May 2021

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NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ.
Jianfeng Huang, Juan F Linares, Angeles Duran, Wenmin Xia, Alan R Saltiel, Jorge Moscat

Nat Commun· May 2021

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Mouse model of colorectal cancer: orthotopic co-implantation of tumor and stroma cells in cecum and rectum.
Hiroaki Kasashima, Angeles Duran, Tania Cid-Diaz, Yu Muta, Hiroto Kinoshita, Jorge Moscat

STAR Protoc· March 2021

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Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.
Hiroaki Kasashima, Angeles Duran, Anxo Martinez-Ordoñez, Yuki Nakanishi, Hiroto Kinoshita, Jorge Moscat

Dev Cell· January 2021

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Jorge Moscat

Autophagy· January 2021

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Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.
Hilaire C Lam, Christian V Baglini, Alicia Llorente Lope, Andrey A Parkhitko, Heng-Jia Liu, Jorge Moscat

Cancer Res· December 2020

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An Orthotopic Implantation Mouse Model of Hepatocellular Carcinoma with Underlying Liver Steatosis.
Hiroaki Kasashima, Angeles Duran, Tania Cid-Diaz, Yotaro Kudo, Maria T Diaz-Meco, Jorge Moscat

STAR Protoc· December 2020

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