Publications by authors named "Joris Pothof"

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A Reporter Platform to Study Therapy-Induced Senescence in Live Cancer Cells.
Jacinta van de Grint, Mengqi Huang, Ruben Sangers, Hanny Odijk, Thom Reuvers, Joris Pothof

Small Methods· December 2025

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Transcriptional stress in aging: integrating experimental data and modeling to quantify DNA damage accumulation.
Jacinta van de Grint, Marko Raseta, Renata Brandt, Yvette van Loon, Joris Demmers, Joris Pothof

Front Mol Biosci· September 2025

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Transcription-coupled DNA-protein crosslink repair by CSB and CRL4-mediated degradation.
Marjolein van Sluis, Qing Yu, Melanie van der Woude, Camila Gonzalo-Hansen, Shannon C Dealy, Joris Pothof

Nat Cell Biol· May 2024

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Age-associated transcriptional stress due to accelerated elongation and increased stalling of RNAPII.
Antonios Papadakis, Akos Gyenis, Joris Pothof, Jan H J Hoeijmakers, Argyris Papantonis

Nat Genet· December 2023

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Trichothiodystrophy-associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation.
Arjan F Theil, Alex Pines, Tuğba Kalayci, José M Heredia-Genestar, Anja Raams, Joris Pothof

EMBO Mol Med· November 2023

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DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice.
Martine de Boer, Maaike Te Lintel Hekkert, Jiang Chang, Bibi S van Thiel, Leonie Martens, Joris Pothof

Aging Cell· March 2023

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Genome-wide RNA polymerase stalling shapes the transcriptome during aging.
Akos Gyenis, Jiang Chang, Joris J P G Demmers, Serena T Bruens, Sander Barnhoorn, Joris Pothof

Nat Genet· February 2023

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Different responses to DNA damage determine ageing differences between organs.
Maria Vougioukalaki, Joris Demmers, Wilbert P Vermeij, Marjolein Baar, Serena Bruens, Joris Pothof

Aging Cell· April 2022

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Organoids Derived from Neoadjuvant FOLFIRINOX Patients Recapitulate Therapy Resistance in Pancreatic Ductal Adenocarcinoma.
Elham Aida Farshadi, Jiang Chang, Bharath Sampadi, Michail Doukas, Freek Van 't Land, Joris Pothof

Clin Cancer Res· December 2021

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The central role of DNA damage in the ageing process.
Björn Schumacher, Joris Pothof, Jan Vijg, Jan H J Hoeijmakers

Nature· April 2021

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Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer.
Myrthe Jager, Francis Blokzijl, Ewart Kuijk, Johanna Bertl, Maria Vougioukalaki, Joris Pothof

Genome Res· July 2019

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Aberrant MicroRNA Expression and Its Implications for Uveal Melanoma Metastasis.
Kyra N Smit, Jiang Chang, Kasper Derks, Jolanda Vaarwater, Tom Brands, Joris Pothof

Cancers (Basel)· June 2019

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Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II.
Barbara Steurer, Roel C Janssens, Bart Geverts, Marit E Geijer, Franziska Wienholz, Joris Pothof

Proc Natl Acad Sci U S A· May 2018

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Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options.
Wilbert P Vermeij, Jan H J Hoeijmakers, Joris Pothof

Annu Rev Pharmacol Toxicol· September 2016

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Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer.
Kishan A T Naipal, Anja Raams, Serena T Bruens, Inger Brandsma, Nicole S Verkaik, Joris Pothof

PLoS One· April 2016

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Deciphering the RNA landscape by RNAome sequencing.
Kasper W J Derks, Branislav Misovic, Mirjam C G N van den Hout, Christel E M Kockx, Cesar Payan Gomez, Joris Pothof

RNA Biol· November 2015

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miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway.
Marijn T M van Jaarsveld, Patricia F van Kuijk, Antonius W M Boersma, Jozien Helleman, Wilfred F van IJcken, Joris Pothof

Mol Cancer· November 2015

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RNAome sequencing delineates the complete RNA landscape.
Kasper W J Derks, Joris Pothof

Genom Data· September 2015

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The DNA damage response: the omics era and its impact.
Kasper W J Derks, Jan H J Hoeijmakers, Joris Pothof

DNA Repair (Amst)· July 2014

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Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures.
Myrrhe van Spronsen, Eljo Y van Battum, Marijn Kuijpers, Vamshidhar R Vangoor, M Liset Rietman, Joris Pothof

PLoS One· June 2014

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Aging: not all DNA damage is equal.
Wilbert P Vermeij, Jan H J Hoeijmakers, Joris Pothof

Curr Opin Genet Dev· June 2014

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DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity.
Marijn T M van Jaarsveld, Maikel D Wouters, Antonius W M Boersma, Marcel Smid, Wilfred F J van Ijcken, Joris Pothof

Mol Oncol· May 2014

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In vivo murine hepatic microRNA and mRNA expression signatures predicting the (non-)genotoxic carcinogenic potential of chemicals.
Joost P M Melis, Kasper W J Derks, Tessa E Pronk, Paul Wackers, Mirjam M Schaap, Joris Pothof

Arch Toxicol· April 2014

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MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells.
Joey Riepsaame, Adri van Oudenaren, Berlinda J H den Broeder, Wilfred F J van Ijcken, Joris Pothof

Front Immunol· November 2013

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