Publications by authors named "Jose Imperio"

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Compound muscle action potential as an early functional in vivo measure of Sarm1 inhibition after sciatic nerve transection.
Seong Kwon Hur, Rebecca R Leahey, Mitchell Geringer, Chang Hoon Cho, Hilda Hernandez-Barry, Jose Imperio

J Neuropathol Exp Neurol· November 2025

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Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism.
Stephen P Schauer, Chang Hoon Cho, Gloriia Novikova, Gillie A Roth, Julie Lee, Jose Imperio

Alzheimers Dement· September 2024

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Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer's Disease and Multiple Sclerosis.
Ainhoa Etxeberria, Yun-An A Shen, Stephen Vito, Sean M Silverman, Jose Imperio

J Neurosci· July 2024

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A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity.
Amy E Byrnes, Filip Roudnicky, Alvin Gogineni, Allison L Soung, Monica Xiong, Jose Imperio

Cell Rep Methods· January 2024

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Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology.
Seung-Hye Lee, William J Meilandt, Luke Xie, Vineela D Gandham, Hai Ngu, Jose Imperio

Neuron· April 2021

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Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS.
Sara Dominguez, Eugene Varfolomeev, Robert Brendza, Kim Stark, Joy Tea, Jose Imperio

Cell Death Differ· March 2021

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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
William J Meilandt, Hai Ngu, Alvin Gogineni, Guita Lalehzadeh, Seung-Hye Lee, Jose Imperio

J Neurosci· February 2020

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Corrigendum to "Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS" Neurobiology of Disease 124 (2019) 340-352.
Arundhati Sengupta-Ghosh, Sara L Dominguez, Luke Xie, Kai H Barck, Zhiyu Jiang, Jose Imperio

Neurobiol Dis· December 2019

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Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ.
William J Meilandt, Janice A Maloney, Jose Imperio, Guita Lalehzadeh, Tim Earr

Alzheimers Res Ther· December 2019

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Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1 mouse model of ALS.
Arundhati Sengupta-Ghosh, Sara L Dominguez, Luke Xie, Kai H Barck, Zhiyu Jiang, Jose Imperio

Neurobiol Dis· April 2019

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Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.
Snahel Patel, William J Meilandt, Rebecca I Erickson, Jinhua Chen, Gauri Deshmukh, Jose Imperio

J Med Chem· October 2017

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Investigation of the rat model for preclinical evaluation of pH-dependent oral absorption in humans.
Joseph W Lubach, Jacob Z Chen, Jonathan Hau, Jose Imperio, Melis Coraggio

Mol Pharm· November 2013

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