Publications by authors named "Jose Maria Cid"

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Discovery and Optimization of a Novel Series of Pyrazolopyrimidines as Spermine Oxidase Inhibitors.
Josep Llaveria, Suraj Adhikary, Christophe Buyck, Santiago Cañellas, Jose Maria Cid

J Med Chem· November 2025

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Discovery of 6,7-Dihydropyrazolo[1,5-]pyrazin-4(5)-one Derivatives as mGluR Negative Allosteric Modulators with Activity in a Rodent's Model of Cognition.
Sergio A Alonso de Diego, María Lourdes Linares, Aránzazu García Molina, Ana Isabel de Lucas, Alcira Del Cerro, Jose María Cid

J Med Chem· September 2024

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Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1-benzimidazol-2-ones as mGlu Receptor PAMs.
Ana Isabel de Lucas, Juan Antonio Vega, Encarnación Matesanz, María Lourdes Linares, Aránzazu García Molina, José María Cid

ACS Med Chem Lett· March 2020

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mGluR2 positive allosteric modulators: an updated patent review (2013-2018).
Andrés A Trabanco, José Manuel Bartolomé, José María Cid

Expert Opin Ther Pat· July 2019

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Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor.
Jose María Cid, Hilde Lavreysen, Gary Tresadern, Laura Pérez-Benito, Fulgencio Tovar

ACS Chem Neurosci· March 2019

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Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization.
Maarten L J Doornbos, Xuesong Wang, Sophie C Vermond, Luc Peeters, Laura Pérez-Benito, José María Cid

J Med Chem· January 2019

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Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2.
Maarten L J Doornbos, José María Cid, Jordi Haubrich, Alexandro Nunes, Jasper W van de Sande

J Med Chem· August 2017

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Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).
Jose María Cid, Gary Tresadern, Juan Antonio Vega, Ana Isabel de Lucas, Alcira Del Cerro

J Med Chem· September 2016

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Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.
Maarten L J Doornbos, Laura Pérez-Benito, Gary Tresadern, Thea Mulder-Krieger, Ilse Biesmans, Jose María Cid

Br J Pharmacol· February 2016

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QSAR design of triazolopyridine mGlu2 receptor positive allosteric modulators.
Gary Tresadern, José-Maria Cid, Andrés A Trabanco

J Mol Graph Model· September 2014

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Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
José María Cid, Gary Tresadern, Guillaume Duvey, Robert Lütjens, Terry Finn

J Med Chem· August 2014

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Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.
Hilde Lavreysen, Xavier Langlois, Abdel Ahnaou, Wilhelmus Drinkenburg, Paula te Riele, Jose Maria Cid

J Pharmacol Exp Ther· September 2013

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mGluR2 positive allosteric modulators: a patent review (2009 - present).
Andrés A Trabanco, José María Cid

Expert Opin Ther Pat· May 2013

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Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging.
José-Ignacio Andrés, Jesús Alcázar, José María Cid, Meri De Angelis, Laura Iturrino

J Med Chem· October 2012

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Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor.
Jose María Cid, Gary Tresadern, Juan Antonio Vega, Ana Isabel de Lucas, Encarnación Matesanz

J Med Chem· October 2012

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Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor.
Andrés A Trabanco, Gary Tresadern, Gregor J Macdonald, Juan Antonio Vega, Ana Isabel de Lucas, José María Cid

J Med Chem· March 2012

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Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.
Jose María Cid, Guillaume Duvey, Gary Tresadern, Vanthea Nhem, Rocco Furnari

J Med Chem· March 2012

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New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.
Andrés A Trabanco, Guillaume Duvey, José María Cid, Gregor J Macdonald, Philippe Cluzeau

Bioorg Med Chem Lett· February 2011

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Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.
Jose María Cid, Guillaume Duvey, Philippe Cluzeau, Vanthea Nhem, Karim Macary

ACS Chem Neurosci· December 2010

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Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.
Gary Tresadern, Jose María Cid, Gregor J Macdonald, Juan Antonio Vega, Ana Isabel de Lucas

Bioorg Med Chem Lett· January 2010

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Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin derivatives as potential anxiolytic agents.
Andrés Avelino Trabanco, José Manuel Alonso, José Ignacio Andrés, José Maria Cid, Javier Fernández

Chem Pharm Bull (Tokyo)· February 2004

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