Publications by authors named "Joseph A Jurcisek"

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Mycobacterium abscessus biofilm cleared from murine lung by monoclonal antibody against bacterial DNABII proteins.
Joseph A Jurcisek, Nikola Kurbatfinski, Kathryn Q Wilbanks, Jaime D Rhodes, Steven D Goodman

J Cyst Fibros· March 2025

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Z-Form Extracellular DNA in Pediatric CRS May Provide a Mechanism for Recalcitrance to Treatment.
Llwyatt K Hofer, Joseph A Jurcisek, Charles Elmaraghy, Steven D Goodman, Lauren O Bakaletz

Laryngoscope· April 2024

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Oral and middle ear delivery of otitis media standard of care antibiotics, but not biofilm-targeted antibodies, alter chinchilla nasopharyngeal and fecal microbiomes.
Audrey F Duff, Joseph A Jurcisek, Nikola Kurbatfinski, Tendy Chiang, Steven D Goodman

NPJ Biofilms Microbiomes· February 2024

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Monoclonal antibodies that target extracellular DNABII proteins or the type IV pilus of nontypeable (NTHI) worked additively to disrupt 2-genera biofilms.
Joseph A Jurcisek, Llwyatt K Hofer, Steven D Goodman, Lauren O Bakaletz

Biofilm· December 2022

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Complement Receptor 3 Mediates HIV-1 Transcytosis across an Intact Cervical Epithelial Cell Barrier: New Insight into HIV Transmission in Women.
Christopher J Day, Rachael L Hardison, Belinda L Spillings, Jessica Poole, Joseph A Jurcisek

mBio· February 2022

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Z-form extracellular DNA is a structural component of the bacterial biofilm matrix.
John R Buzzo, Aishwarya Devaraj, Erin S Gloag, Joseph A Jurcisek, Frank Robledo-Avila

Cell· November 2021

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The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation.
Aishwarya Devaraj, Laura A Novotny, Frank H Robledo-Avila, John R Buzzo, Lauren Mashburn-Warren, Joseph A Jurcisek

J Clin Invest· August 2021

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The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media.
Luke V Blakeway, Aimee Tan, Joseph A Jurcisek, Lauren O Bakaletz, John M Atack

BMC Microbiol· December 2019

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Biofilm biology and vaccine strategies for otitis media due to nontypeable .
Laura A Novotny, Kenneth L Brockman, Elaine M Mokrzan, Joseph A Jurcisek, Lauren O Bakaletz

J Pediatr Infect Dis· February 2019

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Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery.
Kara M Rood, Irina A Buhimschi, Joseph A Jurcisek, Taryn L Summerfield, Guomao Zhao

Sci Rep· June 2018

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Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable .
Jayajit Das, Elaine Mokrzan, Vinal Lakhani, Lucia Rosas, Joseph A Jurcisek

mBio· December 2017

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Nontypeable releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery.
Joseph A Jurcisek, Kenneth L Brockman, Laura A Novotny, Steven D Goodman, Lauren O Bakaletz

Proc Natl Acad Sci U S A· August 2017

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ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media.
Kenneth L Brockman, Joseph A Jurcisek, John M Atack, Yogitha N Srikhanta, Michael P Jennings

J Infect Dis· September 2016

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Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo.
Laura A Novotny, Joseph A Jurcisek, Steven D Goodman, Lauren O Bakaletz

EBioMedicine· August 2016

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Identification of biofilms in post-tympanostomy tube otorrhea.
Winslo K Idicula, Joseph A Jurcisek, Nathan D Cass, Syed Ali, Steven D Goodman

Laryngoscope· August 2016

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Selection and Counterselection of Hia Expression Reveals a Key Role for Phase-Variable Expression of Hia in Infection Caused by Nontypeable Haemophilus influenzae.
John M Atack, Linda E Winter, Joseph A Jurcisek, Lauren O Bakaletz, Stephen J Barenkamp

J Infect Dis· August 2015

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A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.
John M Atack, Yogitha N Srikhanta, Kate L Fox, Joseph A Jurcisek, Kenneth L Brockman

Nat Commun· July 2015

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Antibodies against the majority subunit of type IV Pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media.
Laura A Novotny, Joseph A Jurcisek, Michael O Ward, Zachary B Jordan, Steven D Goodman

Mol Microbiol· April 2015

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Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms.
Christine Cho, Aroon Chande, Lokesh Gakhar, Lauren O Bakaletz, Joseph A Jurcisek

Infect Immun· March 2015

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Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms.
M Elizabeth Brockson, Laura A Novotny, Elaine M Mokrzan, Sankalp Malhotra, Joseph A Jurcisek

Mol Microbiol· September 2014

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Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis.
Subinoy Das, Lucia E Rosas, Joseph A Jurcisek, Laura A Novotny, Kari B Green

Laryngoscope· March 2014

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Antibodies directed against integration host factor mediate biofilm clearance from Nasopore.
Kathleyn A Brandstetter, Joseph A Jurcisek, Steven D Goodman, Lauren O Bakaletz, Subinoy Das

Laryngoscope· November 2013

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Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis.
Jodi E Gustave, Joseph A Jurcisek, Karen S McCoy, Steven D Goodman, Lauren O Bakaletz

J Cyst Fibros· July 2013

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Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media.
M Elizabeth Brockson, Laura A Novotny, Joseph A Jurcisek, Glen McGillivary, Martha R Bowers

PLoS One· November 2012

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In vitro biofilm formation in an 8-well chamber slide.
Joseph A Jurcisek, Amanda C Dickson, Molly E Bruggeman, Lauren O Bakaletz

J Vis Exp· January 2011

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