Publications by authors named "Joseph Avruch"

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Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage.
Laura Regué, William Wang, Fei Ji, Joseph Avruch, Hua Wang

Diabetes· January 2023

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RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression.
Laura Regué, Liping Zhao, Fei Ji, Hua Wang, Joseph Avruch

Mol Metab· June 2021

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A MicroRNA Linking Human Positive Selection and Metabolic Disorders.
Lifeng Wang, Nasa Sinnott-Armstrong, Alexandre Wagschal, Abigail R Wark, Joao-Paulo Camporez, Joseph Avruch

Cell· October 2020

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Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates.
Luke H Chao, Joseph Avruch

F1000Res· June 2020

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The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.
Faisal Alsufyani, Hamid Mattoo, Dawang Zhou, Annaiah Cariappa, Denille Van Buren, Joseph Avruch

Front Immunol· October 2019

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Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation.
Laura Regué, Liliana Minichiello, Joseph Avruch, Ning Dai

J Biol Chem· August 2019

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Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.
William W Greenwald, Joshua Chiou, Jian Yan, Yunjiang Qiu, Ning Dai, Joseph Avruch

Nat Commun· May 2019

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IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism.
Laura Regué, Fei Ji, Daniel Flicker, Dana Kramer, William Pierce, Joseph Avruch

Mol Cell Biol· April 2019

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IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1.
Ning Dai, Fei Ji, Jason Wright, Liliana Minichiello, Ruslan Sadreyev, Joseph Avruch

Elife· July 2017

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MST1/MST2 Protein Kinases: Regulation and Physiologic Roles.
Jacob A Galan, Joseph Avruch

Biochemistry· October 2016

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A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation.
Angela Papageorgiou, Joseph Rapley, Jill P Mesirov, Pablo Tamayo, Joseph Avruch

PLoS One· April 2016

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Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.
Jing Geng, Xiufeng Sun, Ping Wang, Shihao Zhang, Xiaozhen Wang, Joseph Avruch

Nat Immunol· November 2015

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IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.
Ning Dai, Liping Zhao, Diedra Wrighting, Dana Krämer, Amit Majithia, Joseph Avruch

Cell Metab· April 2015

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YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.
Julien Fitamant, Filippos Kottakis, Samira Benhamouche, Helen S Tian, Nicolas Chuvin, Joseph Avruch

Cell Rep· March 2015

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Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.
Noriko Oshiro, Joseph Rapley, Joseph Avruch

J Biol Chem· January 2014

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Hippo signaling regulates differentiation and maintenance in the exocrine pancreas.
Tao Gao, Dawang Zhou, Chenghua Yang, Tarjinder Singh, Alfredo Penzo-Méndez, Joseph Avruch

Gastroenterology· June 2013

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G protein-coupled receptors engage the mammalian Hippo pathway through F-actin: F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene.
Laura Regué, Fan Mou, Joseph Avruch

Bioessays· May 2013

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The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Hongtan Wu, Yubo Xiao, Shihao Zhang, Suyuan Ji, Luyao Wei, Joseph Avruch

Cell Rep· May 2013

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Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes.
Denise L Faustman, Limei Wang, Yoshiaki Okubo, Douglas Burger, Liqin Ban, Joseph Avruch

PLoS One· February 2013

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mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.
Ning Dai, Jan Christiansen, Finn C Nielsen, Joseph Avruch

Genes Dev· February 2013

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Protein kinases of the Hippo pathway: regulation and substrates.
Joseph Avruch, Dawang Zhou, Julien Fitamant, Nabeel Bardeesy, Fan Mou

Semin Cell Dev Biol· September 2012

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The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.
Fan Mou, Maria Praskova, Fan Xia, Denille Van Buren, Hanno Hock, Joseph Avruch

J Exp Med· April 2012

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Hippo pathway in intestinal homeostasis and tumorigenesis.
Lanfen Chen, Funiu Qin, Xianming Deng, Joseph Avruch, Dawang Zhou

Protein Cell· April 2012

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Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.
John M Kyriakis, Joseph Avruch

Physiol Rev· April 2012

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YAP oncogene overexpression supercharges colon cancer proliferation.
Joseph Avruch, Dawang Zhou, Nabeel Bardeesy

Cell Cycle· March 2012

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