Publications by authors named "Joseph B Lin"

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MicroRNA-34a suppresses KLF2 to promote pathological angiogenesis through the CXCR4/CXCL12 pathway in age-related macular degeneration.
Jason J Colasanti, Joseph B Lin, Ryo Terao, Tae Jun Lee, Andrea Santeford

bioRxiv· February 2025

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The Landscape of Vascular Endothelial Growth Factor Inhibition in Retinal Diseases.
Joseph B Lin, Rajendra S Apte

Invest Ophthalmol Vis Sci· January 2025

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Cholesterol Accumulation Promotes Photoreceptor Senescence and Retinal Degeneration.
Ryo Terao, Brian S Sohn, Taku Yamamoto, Tae Jun Lee, Jason Colasanti, Joseph B Lin

Invest Ophthalmol Vis Sci· August 2024

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LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD depletion.
Ryo Terao, Tae Jun Lee, Jason Colasanti, Charles W Pfeifer, Joseph B Lin

Cell Rep· May 2024

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Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function.
Tae Jun Lee, Yo Sasaki, Philip A Ruzycki, Norimitsu Ban, Joseph B Lin

JCI Insight· January 2024

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Targeting cell-type-specific, choroid-peripheral immune signaling to treat age-related macular degeneration.
Joseph B Lin, Andrea Santeford, Jason J Colasanti, Yoon Lee, Aaditya V Shah

Cell Rep Med· January 2024

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Aqueous Macrophages Contribute to Conserved CCL2 and CXCL10 Gradients in Uveitis.
Joseph B Lin, Kathryn L Pepple, Christian Concepcion, Yulia Korshunova, Michael A Paley

Ophthalmol Sci· December 2023

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Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
Charles W Pfeifer, James T Walsh, Andrea Santeford, Joseph B Lin, Wandy L Beatty

Proc Natl Acad Sci U S A· November 2023

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Cell-specific Systemic Immune Signatures Associated with Treatment Burden in Neovascular Age-related Macular Degeneration.
Joseph B Lin, Andrea Santeford, Darksha Usmani, Aaditya V Shah, Philip A Ruzycki

Ophthalmol Sci· October 2023

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Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages.
Joseph B Lin, Amy Mora, Tzu Jui Wang, Andrea Santeford, Darksha Usmani

mBio· August 2023

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Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis.
Joseph B Lin, Xiaolei Shen, Charles W Pfeifer, Fion Shiau, Andrea Santeford

Proc Natl Acad Sci U S A· January 2023

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SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration.
Yo Sasaki, Hiroki Kakita, Shunsuke Kubota, Abdoulaye Sene, Tae Jun Lee, Joseph B Lin

Elife· October 2020

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Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.
Jonathan B Lin, Joseph B Lin, Howard C Chen, Teresa Chen, Rajendra S Apte

Sci Rep· March 2019

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WNT7A/B promote choroidal neovascularization.
Joseph B Lin, Abdoulaye Sene, Luke A Wiley, Andrea Santeford, Eric Nudleman, Jonathan B Lin

Exp Eye Res· September 2018

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Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration.
Jonathan B Lin, Harsh V Moolani, Abdoulaye Sene, Rohini Sidhu, Pamela Kell, Joseph B Lin

JCI Insight· April 2018

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Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).
Natalia Mast, Joseph B Lin, Kyle W Anderson, Ingemar Bjorkhem, Irina A Pikuleva

PLoS One· November 2017

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Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.
Natalia Mast, Kyle W Anderson, Joseph B Lin, Yong Li, Illarion V Turko

J Biol Chem· March 2017

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Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity.
Kyle W Anderson, Natalia Mast, Jeffrey W Hudgens, Joseph B Lin, Illarion V Turko

J Biol Chem· May 2016

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Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis.
Joseph B Lin, Natalia Mast, Ilya R Bederman, Yong Li, Henri Brunengraber

J Lipid Res· February 2016

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Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.
Natalia Mast, Joseph B Lin, Irina A Pikuleva

Mol Pharmacol· September 2015

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