Publications by authors named "Joseph Beckman"

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The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-implications for the toxic gain of function observed in ALS.
Victor A Streltsov, Katherine E Ganio, Stewart D Nuttall, J Andres Hernandez, Cassandra N Dennys, Joseph S Beckman

Neurobiol Dis· December 2025

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Electron Capture Dissociation for Discovery Top-Down Proteomics of Peptides and Small Proteins on Chromatographic Time Scales.
Lester S Manly, Anne M Roberts, Joseph S Beckman, Blaine R Roberts

J Am Soc Mass Spectrom· October 2025

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The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS.
Victor A Streltsov, Katherine E Ganio, Stewart D Nuttall, J Andres Hernandez, Cassandra N Dennys, Joseph S Beckman

bioRxiv· September 2025

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Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis.
James B W Hilton, Kai Kysenius, Jeffrey R Liddell, Stephen W Mercer, Carsten Rautengarten, Joseph S Beckman

Neurotherapeutics· September 2024

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Evidence for disrupted copper availability in human spinal cord supports Cu(atsm) as a treatment option for sporadic cases of ALS.
James B W Hilton, Kai Kysenius, Jeffrey R Liddell, Stephen W Mercer, Bence Paul, Joseph S Beckman

Sci Rep· March 2024

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Microglial ferroptotic stress causes non-cell autonomous neuronal death.
Jeffrey R Liddell, James B W Hilton, Kai Kysenius, Jessica L Billings, Sara Nikseresht, Joseph S Beckman

Mol Neurodegener· February 2024

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Autonomous Synthesis of Functional, Permanently Phosphorylated Proteins for Defining the Interactome of Monomeric 14-3-3ζ.
Phillip Zhu, Stanislau Stanisheuski, Rachel Franklin, Amber Vogel, Cat Hoang Vesely, Joseph S Beckman

ACS Cent Sci· April 2023

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CuATSM effectively ameliorates ALS patient astrocyte-mediated motor neuron toxicity in human in vitro models of amyotrophic lateral sclerosis.
Cassandra N Dennys, Florence Roussel, Rochelle Rodrigo, Xiaojin Zhang, Andrea Sierra Delgado, Joseph Beckman

Glia· February 2023

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Determining Copper and Zinc Content in Superoxide Dismutase Using Electron Capture Dissociation Under Native Spray Conditions.
Rachel Franklin, Michael Hare, Joseph S Beckman

Methods Mol Biol· June 2022

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Nanobody assemblies with fully flexible topology enabled by genetically encoded tetrazine amino acids.
Elise M Van Fossen, Riley M Bednar, Subhashis Jana, Rachel Franklin, Joseph Beckman

Sci Adv· May 2022

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Enhanced Top-Down Protein Characterization with Electron Capture Dissociation and Cyclic Ion Mobility Spectrometry.
Jared B Shaw, Dale A Cooper-Shepherd, Darren Hewitt, Jason L Wildgoose, Joseph S Beckman

Anal Chem· March 2022

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Strategies to protect against age-related mitochondrial decay: Do natural products and their derivatives help?
Francesco Visioli, Avery Ingram, Joseph S Beckman, Kathy R Magnusson, Tory M Hagen

Free Radic Biol Med· January 2022

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PermaPhos : autonomous synthesis of functional, permanently phosphorylated proteins.
Phillip Zhu, Rachel Franklin, Amber Vogel, Stanislau Stanisheuski, Patrick Reardon, Joseph S Beckman

bioRxiv· December 2021

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Genetic Incorporation of Two Mutually Orthogonal Bioorthogonal Amino Acids That Enable Efficient Protein Dual-Labeling in Cells.
Riley M Bednar, Subhashis Jana, Sahiti Kuppa, Rachel Franklin, Joseph Beckman

ACS Chem Biol· November 2021

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Improved Protein and PTM Characterization with a Practical Electron-Based Fragmentation on Q-TOF Instruments.
Joseph S Beckman, Valery G Voinov, Michael Hare, Derrill Sturgeon, Yury Vasil'ev

J Am Soc Mass Spectrom· August 2021

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Capillary Zone Electrophoresis-Electron-Capture Collision-Induced Dissociation on a Quadrupole Time-of-Flight Mass Spectrometer for Top-Down Characterization of Intact Proteins.
Xiaojing Shen, Tian Xu, Blake Hakkila, Mike Hare, Qianjie Wang, Joseph S Beckman

J Am Soc Mass Spectrom· June 2021

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Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis.
Emiliano Trias, Mariángeles Kovacs, Peter H King, Ying Si, Yuri Kwon, Joseph S Beckman

Glia· June 2020

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Comparative Structural Analysis of 20S Proteasome Ortholog Protein Complexes by Native Mass Spectrometry.
Shay Vimer, Gili Ben-Nissan, David Morgenstern, Fanindra Kumar-Deshmukh, Caley Polkinghorn, Joseph S Beckman

ACS Cent Sci· April 2020

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Top-Down Characterization of Denatured Proteins and Native Protein Complexes Using Electron Capture Dissociation Implemented within a Modified Ion Mobility-Mass Spectrometer.
Jonathan P Williams, Lindsay J Morrison, Jeffery M Brown, Joseph S Beckman, Valery G Voinov

Anal Chem· March 2020

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Direct Determination of Antibody Chain Pairing by Top-down and Middle-down Mass Spectrometry Using Electron Capture Dissociation and Ultraviolet Photodissociation.
Jared B Shaw, Weijing Liu, Yury V Vasil Ev, Carter C Bracken, Neha Malhan, Joseph S Beckman

Anal Chem· January 2020

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Neuroprotective effect of CuATSM on neurotoxin-induced motor neuron loss in an ALS mouse model.
Michael T H Kuo, Joseph S Beckman, Christopher A Shaw

Neurobiol Dis· October 2019

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Ligand-independent activation of the P2X7 receptor by Hsp90 inhibition stimulates motor neuron apoptosis.
Amy L Strayer, Cassandra N Dennys-Rivers, Karina C Ricart, Narae Bae, Joseph S Beckman

Exp Biol Med (Maywood)· August 2019

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CD34 Identifies a Subset of Proliferating Microglial Cells Associated with Degenerating Motor Neurons in ALS.
Mariángeles Kovacs, Emiliano Trias, Valentina Varela, Sofia Ibarburu, Joseph S Beckman

Int J Mol Sci· August 2019

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Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS.
Emiliano Trias, Pamela R Beilby, Mariángeles Kovacs, Sofía Ibarburu, Valentina Varela, Joseph S Beckman

Front Aging Neurosci· February 2019

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Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS.
Emiliano Trias, Peter H King, Ying Si, Yuri Kwon, Valentina Varela, Joseph S Beckman

JCI Insight· October 2018

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