Publications by authors named "Joseph D Mancias"

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Targeting KRAS Inhibitor-Resistant Pancreatic Cancer with an MUC1-C Antibody-Drug Conjugate.
Hiroki Ozawa, Kazuki Takahashi, Tomoki Motegi, Justine Jacobi, Atrayee Bhattarchya, Joseph D Mancias

Clin Cancer Res· December 2025

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Stereotactic magnetic resonance imaging-guided adaptive radiotherapy: a pooled analysis of a master prospective trial.
Jonathan E Leeman, Kee-Young Shin, Alexander Droznin, Paul Catalano, Daniel N Cagney, Joseph D Mancias

J Natl Cancer Inst· November 2025

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An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesis.
Justin Loke, Peter G Kim, Thuy T P Nguyen, Meaghan Boileau, Marie McConkey, Joseph D Mancias

Blood· September 2025

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Integrative genomic identification of therapeutic targets for pancreatic cancer.
Jimmy A Guo, Dennis Gong, Kyle Evans, Kazuki Takahashi, Ananya D Jambhale, Joseph D Mancias

Cell Rep· September 2025

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Open-Label, Phase II Trial of Extracellular Regulated Kinase Inhibition Alone and in Combination With Autophagy Inhibition in Patients With Metastatic Pancreatic Cancer.
Rishi Surana, Micaela Morgado, Ashwin Somasundaram, Bruno Bockorny, Colin D Weekes, Joseph D Mancias

JCO Precis Oncol· September 2025

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Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer.
Stephen L DeAngelo, Liang Zhao, Sofia Dziechciarz, Myungsun Shin, Sumeet Solanki, Joseph D Mancias

Cancer Res· August 2025

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De novo pyrimidine biosynthesis inhibition synergizes with BCL-X targeting in pancreatic cancer.
Huan Zhang, Naiara Santana-Codina, Qijia Yu, Clara Poupault, Claudia Campos, Joseph D Mancias

Nat Commun· July 2025

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Autophagosomes anchor an AKAP11-dependent regulatory checkpoint that shapes neuronal PKA signaling.
Ashley Segura-Roman, Y Rose Citron, Myungsun Shin, Nicole Sindoni, Alex Maya-Romero, Joseph D Mancias

EMBO J· June 2025

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The hepcidin-ferroportin axis modulates liver endothelial cell BMP expression to influence iron homeostasis in mice.
Allison L Fisher, Sydney Phillips, Chia-Yu Wang, Joao A Paulo, Xia Xiao, Joseph D Mancias

Blood· February 2025

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IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion.
Lina Herhaus, Uxía Gestal-Mato, Vinay V Eapen, Igor Mačinković, Henry J Bailey, Joseph D Mancias

Cell· December 2024

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BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III.
Brandon Chen, Drew C Stark, Pankaj V Jadhav, Theophilus M Lynn-Nguyen, Benjamin S Halligan, Joseph D Mancias

bioRxiv· November 2024

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Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer.
Julien Dilly, Megan T Hoffman, Laleh Abbassi, Ziyue Li, Francesca Paradiso, Joseph D Mancias

Cancer Discov· November 2024

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Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer.
Stephen L DeAngelo, Liang Zhao, Sofia Dziechciarz, Myungsun Shin, Sumeet Solanki, Joseph D Mancias

bioRxiv· August 2024

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Methods for Monitoring NCOA4-Mediated Ferritinophagy.
Thuy T P Nguyen, Joseph D Mancias

Methods Mol Biol· August 2024

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Autophagosomes coordinate an AKAP11-dependent regulatory checkpoint that shapes neuronal PKA signaling.
Ashley Segura-Roman, Y Rose Citron, Myungsun Shin, Nicole Sindoni, Alex Maya-Romero, Joseph D Mancias

bioRxiv· August 2024

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Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice.
Allison L Fisher, Sydney Phillips, Chia-Yu Wang, Joao A Paulo, Xia Xiao, Joseph D Mancias

Blood· June 2024

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Structural basis for the intracellular regulation of ferritin degradation.
Fabian Hoelzgen, Thuy T P Nguyen, Elina Klukin, Mohamed Boumaiza, Ayush K Srivastava, Joseph D Mancias

Nat Commun· May 2024

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PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer.
Lestat R Ali, Patrick J Lenehan, Victoire Cardot-Ruffino, Andressa Dias Costa, Matthew H G Katz, Joseph D Mancias

Clin Cancer Res· February 2024

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Stereotactic MR-guided on-table adaptive radiation therapy (SMART) for borderline resectable and locally advanced pancreatic cancer: A multi-center, open-label phase 2 study.
Michael D Chuong, Percy Lee, Daniel A Low, Joshua Kim, Kathryn E Mittauer, Joseph D Mancias

Radiother Oncol· February 2024

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Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron.
Allison L Fisher, Chia-Yu Wang, Yang Xu, Sydney Phillips, Joao A Paulo, Joseph D Mancias

iScience· December 2023

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A Multi-Institutional Phase 2 Trial of Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided On-Table Adaptive Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Cancer.
Parag Jitendra Parikh, Percy Lee, Daniel A Low, Joshua Kim, Kathryn E Mittauer, Joseph D Mancias

Int J Radiat Oncol Biol Phys· November 2023

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Gender-Affirming Surgery and Cancer: Considerations for Radiation Oncologists for Pelvic Radiation in Transfeminine Patients.
Alicia C Smart, Kevin X Liu, Jason D Domogauer, Carlos Rodriguez-Russo, Brianna Jones, Joseph D Mancias

Int J Radiat Oncol Biol Phys· October 2023

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Comparison of MR-soft tissue based versus biliary stent based alignment for image guidance in pancreatic SBRT.
Zhaohui Han, Atchar Sudhyadhom, Shu-Hui Hsu, Yue-Houng Hu, Raymond H Mak, Joseph D Mancias

J Appl Clin Med Phys· July 2023

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PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool.
Brandon Chen, Nupur K Das, Indrani Talukder, Rashi Singhal, Cristina Castillo, Joseph D Mancias

J Biol Chem· May 2023

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Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer.
Subhadip Mukhopadhyay, Joel Encarnación-Rosado, Elaine Y Lin, Albert S W Sohn, Huan Zhang, Joseph D Mancias

Sci Adv· April 2023

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