Publications by authors named "Joseph Lachance"

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Integrating Pathogenic Variants, Polygenic Risk Score, and Family History for Prostate Cancer Risk Estimation in Men of African Ancestry.
Fei Chen, Xin Sheng, Anqi Wang, Yili Xu, Raymond Hughley, Joseph Lachance

Eur Urol· November 2025

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Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men.
Rohini Janivara, Ujani Hazra, Aaron Pfennig, Maxine Harlemon, Michelle S Kim, Joseph Lachance

HGG Adv· July 2025

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Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.
Thomas J Hoffmann, Rebecca E Graff, Ravi K Madduri, Alex A Rodriguez, Clinton L Cario, Joseph Lachance

Nat Genet· February 2025

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Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.
Rohini Janivara, Wenlong C Chen, Ujani Hazra, Shakuntala Baichoo, Ilir Agalliu, Joseph Lachance

Nat Genet· October 2024

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Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction.
Thomas J Hoffmann, Rebecca E Graff, Ravi K Madduri, Alex A Rodriguez, Clinton L Cario, Joseph Lachance

medRxiv· August 2024

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The evolutionary fate of Neanderthal DNA in 30,780 admixed genomes with recent African-like ancestry.
Aaron Pfennig, Joseph Lachance

bioRxiv· July 2024

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Does Effective Population Size Govern Evolutionary Differences in Telomere Length?
Lyda M Brown, Mia C Elbon, Ajay Bharadwaj, Gargi Damle, Joseph Lachance

Genome Biol Evol· May 2024

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Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men.
Rohini Janivara, Ujani Hazra, Aaron Pfennig, Maxine Harlemon, Michelle S Kim, Joseph Lachance

bioRxiv· January 2024

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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
Anqi Wang, Jiayi Shen, Alex A Rodriguez, Edward J Saunders, Fei Chen, Joseph Lachance

Nat Genet· December 2023

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Heterogeneous genetic architectures and evolutionary genomics of prostate cancer in Sub-Saharan Africa.
Timothy Rebbeck, Rohini Janivara, Wenlong Chen, Ujani Hazra, Shakuntala Baichoo, Joseph Lachance

Res Sq· October 2023

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Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry.
Fei Chen, Ravi K Madduri, Alex A Rodriguez, Burcu F Darst, Alisha Chou, Joseph Lachance

Eur Urol· July 2023

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Evolutionary Genetics and Admixture in African Populations.
Aaron Pfennig, Lindsay N Petersen, Paidamoyo Kachambwa, Joseph Lachance

Genome Biol Evol· April 2023

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Challenges of accurately estimating sex-biased admixture from X chromosomal and autosomal ancestry proportions.
Aaron Pfennig, Joseph Lachance

Am J Hum Genet· February 2023

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Genome of the endangered Guatemalan Beaded Lizard, Heloderma charlesbogerti, reveals evolutionary relationships of squamates and declines in effective population sizes.
Carl J Dyson, Aaron Pfennig, Daniel Ariano-Sánchez, Joseph Lachance, Joseph R Mendelson Iii

G3 (Bethesda)· December 2022

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Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa.
Michelle S Kim, Daphne Naidoo, Ujani Hazra, Melanie H Quiver, Wenlong C Chen, Joseph Lachance

Genome Biol· September 2022

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Hybrid fitness effects modify fixation probabilities of introgressed alleles.
Aaron Pfennig, Joseph Lachance

G3 (Bethesda)· July 2022

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Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations.
Fei Chen, Burcu F Darst, Ravi K Madduri, Alex A Rodriguez, Xin Sheng, Joseph Lachance

Elife· July 2022

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A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry.
Burcu F Darst, Raymond Hughley, Aaron Pfennig, Ujani Hazra, Caoqi Fan, Joseph Lachance

Eur Urol· May 2022

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Adaptive eQTLs reveal the evolutionary impacts of pleiotropy and tissue-specificity while contributing to health and disease.
Melanie H Quiver, Joseph Lachance

HGG Adv· January 2022

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Beyond Stamp Collecting: Evolutionary and Functional Genomics Advance Our Understanding of Cancer Biology.
Joseph Lachance

Cancer Res· April 2021

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Large sample spaces do not imply biological systems are 'fine-tuned'.
Joseph Lachance, Corinne N Simonti, Joshua S Weitz

J Theor Biol· December 2020

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A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa.
Maxine Harlemon, Olabode Ajayi, Paidamoyo Kachambwa, Michelle S Kim, Corinne N Simonti, Joseph Lachance

Cancer Res· July 2020

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Evolving Antibiotics against Resistance: a Potential Platform for Natural Product Development?
Kristofer Wollein Waldetoft, James Gurney, Joseph Lachance, Paul A Hoskisson, Sam P Brown

mBio· December 2019

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Genetic disease risks can be misestimated across global populations.
Michelle S Kim, Kane P Patel, Andrew K Teng, Ali J Berens, Joseph Lachance

Genome Biol· November 2018

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Development, Evaluation, and Implementation of a Pan-African Cancer Research Network: Men of African Descent and Carcinoma of the Prostate.
Caroline Andrews, Brian Fortier, Amy Hayward, Ruth Lederman, Lindsay Petersen, Joseph Lachance

J Glob Oncol· September 2018

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