Publications by authors named "Joseph Perchiacca"

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Navigating PUPSIT implementation challenges for high-viscosity oligonucleotide drug products.
Yu Zoe Zhang, Joseph Perchiacca, Anya Batalina, Mery George De la Rosa, Jian Lu

J Pharm Sci· November 2025

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Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.
Joseph M Perchiacca, Christine C Lee, Peter M Tessier

Protein Eng Des Sel· February 2014

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Toward aggregation-resistant antibodies by design.
Christine C Lee, Joseph M Perchiacca, Peter M Tessier

Trends Biotechnol· November 2013

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Rational design of potent domain antibody inhibitors of amyloid fibril assembly.
Ali Reza A Ladiwala, Moumita Bhattacharya, Joseph M Perchiacca, Ping Cao, Daniel P Raleigh

Proc Natl Acad Sci U S A· December 2012

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Engineering aggregation-resistant antibodies.
Joseph M Perchiacca, Peter M Tessier

Annu Rev Chem Biomol Eng· October 2012

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Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions.
Joseph M Perchiacca, Ali Reza A Ladiwala, Moumita Bhattacharya, Peter M Tessier

Protein Eng Des Sel· October 2012

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Polyphenolic disaccharides endow proteins with unusual resistance to aggregation.
Ali Reza A Ladiwala, Joseph M Perchiacca, Zachary S Fishman, Moumita Bhattacharya, Anne Marie Hickey

Biotechnol Bioeng· July 2012

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Structure-based design of conformation- and sequence-specific antibodies against amyloid β.
Joseph M Perchiacca, Ali Reza A Ladiwala, Moumita Bhattacharya, Peter M Tessier

Proc Natl Acad Sci U S A· January 2012

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Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions.
Joseph M Perchiacca, Moumita Bhattacharya, Peter M Tessier

Proteins· September 2011

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