Publications by authors named "Joseph Schlessinger"

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Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α.
Seong An, Yoshihisa Suzuki, Jyotidarsini Mohanty, Francisco Tome, Irit Lax, Joseph Schlessinger

bioRxiv· December 2025

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Inducible FAK loss but not FAK inhibition in endothelial cells of PYK2-null mice activates p53 tumor suppressor to prevent tumor growth.
Xiao Lei Chen, Marjaana Ojalill, Christine Jean, Isabelle Tancioni, Shulin Jiang, Joseph Schlessinger

Mol Biol Cell· June 2025

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Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.
Mélissa Delanne-Cuménal, Manon Defaye, Améline Delanne-Cuménal, Mansoor Ahmed, Valerie Ho, Joseph Schlessinger

Proc Natl Acad Sci U S A· June 2025

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Exposing the obscured influence of state-controlled media via causal inference of quotation propagation.
Joseph Schlessinger, Richard Bennet, Jacob Coakwell, Steven Smith, Edward Kao

Sci Rep· January 2025

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Inducible FAK Deletion but not FAK Inhibition in Endothelial Cells Activates p53 to Suppress Tumor Growth in PYK2-null Mice.
Xiao Lei Chen, Marjaana Ojalill, Christine Jean, Isabelle Tancioni, Shulin Jiang, Joseph Schlessinger

bioRxiv· November 2024

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Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.
Natasha I Edman, Ashish Phal, Rachel L Redler, Thomas Schlichthaerle, Sanjay R Srivatsan, Joseph Schlessinger

Cell· July 2024

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Expression of Concern: Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection.
Lynn A Kamen, Joseph Schlessinger, Clifford A Lowell

J Immunol· May 2024

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Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix.
Stefania Bellone, Kyungjo Jeong, Mari Kyllesø Halle, Camilla Krakstad, Blair McNamara, Joseph Schlessinger

Proc Natl Acad Sci U S A· April 2024

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Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor.
Blair McNamara, Justin Harold, Diego Manavella, Stefania Bellone, Levent Mutlu, Joseph Schlessinger

Gynecol Oncol· May 2023

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Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Stefan G Krimmer, Nicole Bertoletti, Yoshihisa Suzuki, Luka Katic, Jyotidarsini Mohanty, Joseph Schlessinger

Proc Natl Acad Sci U S A· March 2023

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Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.
Natasha I Edman, Rachel L Redler, Ashish Phal, Thomas Schlichthaerle, Sanjay R Srivatsan, Joseph Schlessinger

bioRxiv· March 2023

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Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability.
Seong J An, Jyotidarsini Mohanty, Francisco Tome, Yoshihisa Suzuki, Irit Lax, Joseph Schlessinger

Proc Natl Acad Sci U S A· February 2023

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Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants.
Stefan G Krimmer, Joseph Schlessinger

Proc Natl Acad Sci U S A· December 2022

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Covalent Modification of the JH2 Domain of Janus Kinase 2.
Sean P Henry, Maria-Elena Liosi, Joseph A Ippolito, Fabian Menges, Ana S Newton, Joseph Schlessinger

ACS Med Chem Lett· November 2022

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Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis.
Seong J An, Alexander Anneken, Zhiqun Xi, Changseon Choi, Joseph Schlessinger

Proc Natl Acad Sci U S A· November 2022

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Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein.
Joon Sung Park, Jungyuen Choi, Longxing Cao, Jyotidarsini Mohanty, Yoshihisa Suzuki, Joseph Schlessinger

Cell Rep· October 2022

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Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.
Maria-Elena Liosi, Joseph A Ippolito, Sean P Henry, Stefan G Krimmer, Ana S Newton, Joseph Schlessinger

J Med Chem· June 2022

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Design of protein-binding proteins from the target structure alone.
Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joseph Schlessinger

Nature· May 2022

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Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies.
Sean P Henry, Maria-Elena Liosi, Joseph A Ippolito, Kara J Cutrona, Stefan G Krimmer, Joseph Schlessinger

ACS Med Chem Lett· May 2022

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A hypothalamic pathway for Augmentor α-controlled body weight regulation.
Mansoor Ahmed, Navjot Kaur, Qianni Cheng, Marya Shanabrough, Evgenii O Tretiakov, Joseph Schlessinger

Proc Natl Acad Sci U S A· April 2022

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Structural basis for ligand reception by anaplastic lymphoma kinase.
Tongqing Li, Steven E Stayrook, Yuko Tsutsui, Jianan Zhang, Yueyue Wang, Joseph Schlessinger

Nature· December 2021

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Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Andrey V Reshetnyak, Paolo Rossi, Alexander G Myasnikov, Munia Sowaileh, Jyotidarsini Mohanty, Joseph Schlessinger

Nature· December 2021

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Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant.
Ana S Newton, Maria-Elena Liosi, Sean P Henry, Luca Deiana, John C Faver, Joseph Schlessinger

Tetrahedron Lett· August 2021

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Integrated mutational landscape analysis of uterine leiomyosarcomas.
Jungmin Choi, Aranzazu Manzano, Weilai Dong, Stefania Bellone, Elena Bonazzoli, Joseph Schlessinger

Proc Natl Acad Sci U S A· April 2021

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Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.
Mo Zhou, Leena Kuruvilla, Xiarong Shi, Stephen Viviano, Ian M Ahearn, Joseph Schlessinger

Proc Natl Acad Sci U S A· December 2020

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