Publications by authors named "Joseph Schrag"

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Sequence tolerance of immunoglobulin variable domain framework regions to noncanonical intradomain disulfide linkages.
Dae Young Kim, Hiba Kandalaft, Michael J Lowden, Qingling Yang, Martin A Rossotti, Joseph D Schrag

J Biol Chem· November 2023

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Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates.
Matthew Stuible, Joseph D Schrag, Joey Sheff, Daria Zoubchenok, Simon Lord-Dufour

Sci Rep· October 2023

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A CHO stable pool production platform for rapid clinical development of trimeric SARS-CoV-2 spike subunit vaccine antigens.
Simon Joubert, Matthew Stuible, Simon Lord-Dufour, Linda Lamoureux, François Vaillancourt, Joseph D Schrag

Biotechnol Bioeng· July 2023

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An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity.
Nina E Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O'Toole, Elizabeth Whalen, Joseph D Schrag

Nat Commun· March 2023

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Corrigendum: Structure-guided design of a potent toxin A inhibitor.
Greg Hussack, Martin A Rossotti, Henk van Faassen, Tomohiko Murase, Luiz Eugenio, Joseph D Schrag

Front Microbiol· March 2023

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Structure-guided design of a potent toxin A inhibitor.
Greg Hussack, Martin A Rossotti, Henk van Faassen, Tomohiko Murase, Luiz Eugenio, Joseph D Schrag

Front Microbiol· January 2023

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Characterization of a SARS-CoV-2 spike protein reference material.
Bradley B Stocks, Marie-Pier Thibeault, Joseph D Schrag, Jeremy E Melanson

Anal Bioanal Chem· May 2022

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Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9.
Pranav R H Joshi, Alice Bernier, Pablo D Moço, Joseph Schrag, Parminder S Chahal

Mol Ther Methods Clin Dev· June 2021

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Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment.
Traian Sulea, Nazanin Rohani, Jason Baardsnes, Christopher R Corbeil, Christophe Deprez, Joseph D Schrag

MAbs· January 2021

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Rapid, high-yield production of full-length SARS-CoV-2 spike ectodomain by transient gene expression in CHO cells.
Matthew Stuible, Christian Gervais, Simon Lord-Dufour, Sylvie Perret, Denis L'Abbé, Joseph Schrag

J Biotechnol· January 2021

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Binding symmetry and surface flexibility mediate antibody self-association.
Joseph D Schrag, Marie-Ève Picard, Francis Gaudreault, Louis-Patrick Gagnon, Jason Baardsnes

MAbs· October 2019

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Achieving High-Yield Production of Functional AAV5 Gene Delivery Vectors via Fedbatch in an Insect Cell-One Baculovirus System.
Pranav R H Joshi, Laura Cervera, Ibrahim Ahmed, Oleksandr Kondratov, Sergei Zolotukhin, Joseph Schrag

Mol Ther Methods Clin Dev· June 2019

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Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human V/V Single-Domain Antibodies from Display Libraries.
Kevin A Henry, Dae Young Kim, Hiba Kandalaft, Michael J Lowden, Qingling Yang, Joseph D Schrag

Front Immunol· December 2017

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Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function.
Eric Escobar-Cabrera, Paula Lario, Jason Baardsnes, Joseph Schrag, Yves Durocher

Antibodies (Basel)· May 2017

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Antibody light chain variable domains and their biophysically improved versions for human immunotherapy.
Dae Young Kim, Rebecca To, Hiba Kandalaft, Wen Ding, Henk van Faassen, Joseph D Schrag

MAbs· October 2014

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Structural and enzymatic characterization of NanS (YjhS), a 9-O-Acetyl N-acetylneuraminic acid esterase from Escherichia coli O157:H7.
Erumbi S Rangarajan, Karen M Ruane, Ariane Proteau, Joseph D Schrag, Ricardo Valladares

Protein Sci· July 2011

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Different active-site loop orientation in serine hydrolases versus acyltransferases.
Yun Jiang, Krista L Morley, Joseph D Schrag, Romas J Kazlauskas

Chembiochem· March 2011

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Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase.
De Lu Tyler Yin, Peter Bernhardt, Krista L Morley, Yun Jiang, Jeremy D Cheeseman, Joseph D Schrag

Biochemistry· March 2010

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Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72.
Guennadi Kozlov, Pekka Määttänen, Joseph D Schrag, Greg L Hura, Lisa Gabrielli

Structure· May 2009

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Molecular dynamics-solvated interaction energy studies of protein-protein interactions: the MP1-p14 scaffolding complex.
Qizhi Cui, Traian Sulea, Joseph D Schrag, Christine Munger, Ming-Ni Hung

J Mol Biol· June 2008

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The crystal structure and dimerization interface of GADD45gamma.
Joseph D Schrag, Sarn Jiralerspong, Myriam Banville, Maria Luz Jaramillo, Maureen D O'Connor-McCourt

Proc Natl Acad Sci U S A· May 2008

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Crystal structure of the bb' domains of the protein disulfide isomerase ERp57.
Guennadi Kozlov, Pekka Maattanen, Joseph D Schrag, Stephanie Pollock, Miroslaw Cygler

Structure· August 2006

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The structure of the exopolyphosphatase (PPX) from Escherichia coli O157:H7 suggests a binding mode for long polyphosphate chains.
Erumbi S Rangarajan, Guy Nadeau, Yunge Li, John Wagner, Ming-Ni Hung, Joseph D Schrag

J Mol Biol· June 2006

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Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI.
J Sivaraman, Rebecca S Myers, Lorena Boju, Traian Sulea, Miroslaw Cygler, Joseph D Schrag

Biochemistry· August 2005

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Mirror-image packing in enantiomer discrimination molecular basis for the enantioselectivity of B.cepacia lipase toward 2-methyl-3-phenyl-1-propanol.
Alessandra Mezzetti, Joseph D Schrag, Chan Seong Cheong, Romas J Kazlauskas

Chem Biol· April 2005

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