Publications by authors named "Joshua A Keefe"

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Macrophage Migration Inhibitory Factor: the Next Adjunct to Reperfusion Therapy in Acute Myocardial Infarction?
Joshua A Keefe, Xander H T Wehrens

Cardiovasc Drugs Ther· December 2025

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Multiomic and electrophysiologic analyses reveal that an inherited MRC2 variant causes fibroblast dysfunction and increased atrial fibrillation susceptibility.
Kevin S Ho, Joshua A Keefe, Shuai Zhao, Mohit M Hulsurkar, Sung Yun Jung

Am J Physiol Heart Circ Physiol· November 2025

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Cyclic AMP-dependent regulation of ryanodine receptors in healthy and diseased hearts.
Mohit M Hulsurkar, Isabelle Ong, Joshua A Keefe, Issam H Abu-Taha, Dobromir Dobrev

J Mol Cell Cardiol· November 2025

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Atrial fibroblast-derived macrophage migration inhibitory factor promotes atrial macrophage accumulation in postoperative atrial fibrillation.
Joshua A Keefe, Jose Alberto Navarro-Garcia, Shuai Zhao, Mihail G Chelu, Xander Ht Wehrens

JCI Insight· September 2025

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Mechanisms underlying atrial fibrillation in chronic kidney disease.
Jose Alberto Navarro-Garcia, Joshua A Keefe, Jia Song, Na Li, Xander H T Wehrens

J Mol Cell Cardiol· August 2025

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Macrophage-mediated IL-6 signaling drives ryanodine receptor-2 calcium leak in postoperative atrial fibrillation.
Joshua A Keefe, Yuriana Aguilar-Sanchez, J Alberto Navarro-Garcia, Isabelle Ong, Luge Li

J Clin Invest· May 2025

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Immune cells and arrhythmias.
Joshua A Keefe, Jian Wang, Jiangping Song, Li Ni, Xander H T Wehrens

Cardiovasc Res· April 2025

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A mechanistic LNK between inflammation and atrial fibrillation?
Joshua A Keefe, Shuai Zhao, Xander H T Wehrens

Cardiovasc Res· July 2024

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Tachycardia and Atrial Fibrillation-Related Cardiomyopathies: Potential Mechanisms and Current Therapies.
Joshua A Keefe, Rebecca Garber, Mark D McCauley, Xander H T Wehrens

JACC Heart Fail· April 2024

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Long-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardia.
Oliver M Moore, Yuriana Aguilar-Sanchez, Satadru K Lahiri, Mohit M Hulsurkar, J Alberto Navarro-Garcia, Joshua A Keefe

J Cardiovasc Aging· January 2024

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Blocking p38γ/δ, a molecular cardiac defibrillator.
Joshua A Keefe, Xander H T Wehrens

Nat Cardiovasc Res· December 2023

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Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation.
Jia Song, Jose Alberto Navarro-Garcia, Jiao Wu, Arnela Saljic, Issam Abu-Taha, Joshua A Keefe

J Clin Invest· October 2023

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Endothelial cell dysfunction: the culprit for cardiac denervation in aging?
Oliver M Moore, Joshua A Keefe, Xander H T Wehrens

J Cardiovasc Aging· October 2023

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Anti-Ro/SSA Antibodies in Atrioventricular Block: Innocent Bystander or Mechanistic Driver?
Joshua A Keefe, Xander H T Wehrens

JACC Clin Electrophysiol· August 2023

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Mouse models of spontaneous atrial fibrillation.
Joshua A Keefe, Mohit M Hulsurkar, Svetlana Reilly, Xander H T Wehrens

Mamm Genome· June 2023

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Role of Ca in healthy and pathologic cardiac function: from normal excitation-contraction coupling to mutations that cause inherited arrhythmia.
Joshua A Keefe, Oliver M Moore, Kevin S Ho, Xander H T Wehrens

Arch Toxicol· January 2023

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Cardiac function, structural, and electrical remodeling by microgravity exposure.
Mary R Sy, Joshua A Keefe, Jeffrey P Sutton, Xander H T Wehrens

Am J Physiol Heart Circ Physiol· January 2023

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Abnormalities in cardiac and inflammatory biomarkers in ambulatory subjects after COVID-19 infection.
Joshua A Keefe, Vasanthi Avadhanula, Erin G Nicholson, Sridevi Devaraj, Pedro A Piedra

Int J Cardiol Heart Vasc· December 2022

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Diagnosing atrial fibrillation: Can we do better than the ECG?
Kevin S Ho, Joshua A Keefe, Xander H T Wehrens

Heart Rhythm· September 2022

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Common disease-promoting signalling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences.
Joshua A Keefe, Xander H T Wehrens, Dobromir Dobrev

Cardiovasc Res· August 2022

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In-depth characterization of a mouse model of postoperative atrial fibrillation.
Joshua A Keefe, Jose Alberto Navarro-Garcia, Li Ni, Svetlana Reilly, Dobromir Dobrev

J Cardiovasc Aging· July 2022

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Evidence for a Causal Role of the SH2B3-βM Axis in Blood Pressure Regulation.
Joshua A Keefe, Shih-Jen Hwang, Tianxiao Huan, Michael Mendelson, Chen Yao

Hypertension· February 2019

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Multigenerational memory and adaptive adhesion in early bacterial biofilm communities.
Calvin K Lee, Jaime de Anda, Amy E Baker, Rachel R Bennett, Yun Luo, Joshua A Keefe

Proc Natl Acad Sci U S A· April 2018

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