Publications by authors named "Joshua B Simpson"

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Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.
Amanda L Graboski, Joshua B Simpson, Samuel J Pellock, Naimee Mehta, Benjamin C Creekmore

RSC Chem Biol· August 2024

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Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Joshua B Simpson, Morgan E Walker, Joshua J Sekela, Samantha M Ivey, Parth B Jariwala

Cell Host Microbe· June 2024

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Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.
Amanda L Graboski, Mark E Kowalewski, Joshua B Simpson, Xufeng Cao, Mary Ha

Cell Chem Biol· November 2023

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Diverse but desolate landscape of gut microbial azoreductases: A rationale for idiopathic IBD drug response.
Joshua B Simpson, Josh J Sekela, Benjamin S Carry, Violet Beaty, Shakshi Patel

Gut Microbes· May 2023

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Microbial β-glucuronidases drive human periodontal disease etiology.
Adam D Lietzan, Joshua B Simpson, William G Walton, Parth B Jariwala, Yongmei Xu

Sci Adv· May 2023

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Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.
Matthew H Foley, Morgan E Walker, Allison K Stewart, Sarah O'Flaherty, Emily C Gentry, Joshua B Simpson

Nat Microbiol· April 2023

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Multi-omic analysis of host-microbial interactions central to the gut-brain axis.
Joshua B Simpson, Matthew R Redinbo

Mol Omics· December 2022

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A structural metagenomics pipeline for examining the gut microbiome.
Morgan E Walker, Joshua B Simpson, Matthew R Redinbo

Curr Opin Struct Biol· August 2022

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Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate.
Joshua B Simpson, Josh J Sekela, Amanda L Graboski, Valentina B Borlandelli, Marissa M Bivins

Gut Microbes· August 2022

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Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.
Adam L Edwinson, Lu Yang, Stephanie Peters, Nikita Hanning, Patricio Jeraldo, Joshua B Simpson

Nat Microbiol· May 2022

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Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.
Jianan Zhang, Morgan E Walker, Katherine Z Sanidad, Hongna Zhang, Yanshan Liang, Joshua B Simpson

Nat Commun· January 2022

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Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases.
Samantha M Ervin, Joshua B Simpson, Morgan E Gibbs, Benjamin C Creekmore, Lauren Lim

Biochemistry· October 2020

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Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling.
Parth B Jariwala, Samuel J Pellock, Dennis Goldfarb, Erica W Cloer, Marta Artola, Joshua B Simpson

ACS Chem Biol· January 2020

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Prebiotics for Lactose Intolerance: Variability in Galacto-Oligosaccharide Utilization by Intestinal .
Jason W Arnold, Joshua B Simpson, Jeffery Roach, Jose M Bruno-Barcena, M Andrea Azcarate-Peril

Nutrients· October 2018

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Intra-species Genomic and Physiological Variability Impact Stress Resistance in Strains of Probiotic Potential.
Jason W Arnold, Joshua B Simpson, Jeffrey Roach, Jakub Kwintkiewicz, M Andrea Azcarate-Peril

Front Microbiol· February 2018

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