Publications by authors named "Joshua D Simpson"

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Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy.
Gayathri R Ediriweera, Amal J Sivaram, Gary Cowin, Mikayla L Brown, Luke McAlary, Joshua D Simpson

J Control Release· February 2025

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From viral assembly to host interaction: AFM's contributions to virology.
Ankita Ray, Joshua D Simpson, Irem Demir, Victor G Gisbert, David B Gomes

J Virol· January 2025

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Single-Molecule Investigation of the Binding Interface Stability of SARS-CoV-2 Variants with ACE2.
Ankita Ray, Thu Thi Minh Tran, Rita Dos Santos Natividade, Rodrigo A Moreira, Joshua D Simpson

ACS Nanosci Au· April 2024

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Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus.
Pengcheng Shang, Joshua D Simpson, Gwen M Taylor, Danica M Sutherland, Olivia L Welsh

Nat Commun· May 2023

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Deciphering molecular mechanisms stabilizing the reovirus-binding complex.
Rita Dos Santos Natividade, Melanie Koehler, Priscila S F C Gomes, Joshua D Simpson, Sydni Caet Smith

Proc Natl Acad Sci U S A· May 2023

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Single-Molecule Analysis of SARS-CoV-2 Binding to C-Type Lectin Receptors.
Joshua D Simpson, Ankita Ray, Claire Marcon, Rita Dos Santos Natividade, Gol Mohammad Dorrazehi

Nano Lett· February 2023

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Enhanced drug delivery to cancer cells through a pH-sensitive polycarbonate platform.
Maria C Arno, Joshua D Simpson, Lewis D Blackman, Ruairí P Brannigan, Kristofer J Thurecht

Biomater Sci· January 2023

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Modulating Macrophage Clearance of Nanoparticles: Comparison of Small-Molecule and Biologic Drugs as Pharmacokinetic Modifiers of Soft Nanomaterials.
Jessica A Mills, James Humphries, Joshua D Simpson, Stefan E Sonderegger, Kristofer J Thurecht

Mol Pharm· November 2022

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Atomic force microscopy applied to interrogate nanoscale cellular chemistry and supramolecular bond dynamics for biomedical applications.
Joshua D Simpson, Ankita Ray, Melanie Koehler, Danahe Mohammed, David Alsteens

Chem Commun (Camb)· April 2022

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Role of the Redox State of Human Peroxiredoxin-5 on Its TLR4-Activating DAMP Function.
Mégane A Poncin, Pierre Van Meerbeeck, Joshua D Simpson, André Clippe, François Tyckaert

Antioxidants (Basel)· November 2021

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Cyanine-5-Driven Behaviours of Hyperbranched Polymers Designed for Therapeutic Delivery Are Cell-Type Specific and Correlated with Polar Lipid Distribution in Membranes.
Joshua D Simpson, Denni L Currin-Ross, Gayathri R Ediriweera, Horst Joachim Schirra, Nicholas L Fletcher

Nanomaterials (Basel)· July 2021

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Fluorophore Selection and Incorporation Contribute to Permeation and Distribution Behaviors of Hyperbranched Polymers in Multi-Cellular Tumor Spheroids and Xenograft Tumor Models.
Joshua D Simpson, Patrícia F Monteiro, Gayathri R Ediriweera, Amber R Prior, Stefan E Sonderegger

ACS Appl Bio Mater· March 2021

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Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery.
Gayathri R Ediriweera, Joshua D Simpson, Adrian V Fuchs, Taracad K Venkatachalam, Matthias Van De Walle

Chem Sci· March 2020

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Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells.
Joshua D Simpson, Gayathri R Ediriweera, Christopher B Howard, Nicholas L Fletcher, Craig A Bell

Biomater Sci· November 2019

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Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface.
Joshua D Simpson, Samuel A Smith, Kristofer J Thurecht, Georgina Such

Polymers (Basel)· September 2019

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Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice.
Liyu Chen, Joshua D Simpson, Adrian V Fuchs, Barbara E Rolfe, Kristofer J Thurecht

Mol Pharm· December 2017

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Localised delivery of doxorubicin to prostate cancer cells through a PSMA-targeted hyperbranched polymer theranostic.
Amanda K Pearce, Joshua D Simpson, Nicholas L Fletcher, Zachary H Houston, Adrian V Fuchs

Biomaterials· October 2017

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Using Peptide Aptamer Targeted Polymers as a Model Nanomedicine for Investigating Drug Distribution in Cancer Nanotheranostics.
Yongmei Zhao, Zachary H Houston, Joshua D Simpson, Liyu Chen, Nicholas L Fletcher

Mol Pharm· October 2017

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Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies.
Christopher B Howard, Nicholas Fletcher, Zachary H Houston, Adrian V Fuchs, Nathan R B Boase, Joshua D Simpson

Adv Healthc Mater· August 2016

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