Publications by authors named "Joshua D Thomas"

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XMT-2056, a HER2-Directed STING Agonist Antibody-Drug Conjugate, Induces Innate Antitumor Immune Responses by Acting on Cancer Cells and Tumor-Resident Immune Cells.
Raghida A Bukhalid, Jeremy R Duvall, Kelly Lancaster, Kalli C Catcott, Naniye Malli Cetinbas, Joshua D Thomas

Clin Cancer Res· May 2025

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Development of a Novel DNA Mono-alkylator Platform for Antibody-Drug Conjugates.
Joshua D Thomas, Aleksandr V Yurkovetskiy, Mao Yin, Natalya D Bodyak, Shuyi Tang

Mol Cancer Ther· April 2024

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Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates.
Jeremy R Duvall, Joshua D Thomas, Raghida A Bukhalid, Kalli C Catcott, Keith W Bentley

J Med Chem· August 2023

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Discovery of novel polyamide-pyrrolobenzodiazepine hybrids for antibody-drug conjugates.
Joshua D Thomas, Aleksandr V Yurkovetskiy, Mao Yin, Natalya D Bodyak, Dmitry R Gumerov

Bioorg Med Chem Lett· September 2022

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Dolaflexin: A Novel Antibody-Drug Conjugate Platform Featuring High Drug Loading and a Controlled Bystander Effect.
Aleksandr V Yurkovetskiy, Natalya D Bodyak, Mao Yin, Joshua D Thomas, Susan M Clardy

Mol Cancer Ther· May 2021

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A Polymer-Based Antibody-Vinca Drug Conjugate Platform: Characterization and Preclinical Efficacy.
Alexander V Yurkovetskiy, Mao Yin, Natalya Bodyak, Cheri A Stevenson, Joshua D Thomas

Cancer Res· August 2015

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Tumor Necrosis Factor (TNF) Receptor Superfamily Member 1b on CD8+ T Cells and TNF Receptor Superfamily Member 1a on Non-CD8+ T Cells Contribute Significantly to Upper Genital Tract Pathology Following Chlamydial Infection.
Srikanth Manam, Joshua D Thomas, Weidang Li, Allison Maladore, Justin H Schripsema

J Infect Dis· June 2015

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Harnessing the fcμ receptor for potent and selective cytotoxic therapy of chronic lymphocytic leukemia.
Bérengère Vire, Martin Skarzynski, Joshua D Thomas, Christopher G Nelson, Alexandre David

Cancer Res· December 2014

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Application of strain-promoted azide-alkyne cycloaddition and tetrazine ligation to targeted Fc-drug conjugates.
Joshua D Thomas, Huiting Cui, Patrick J North, Thomas Hofer, Christoph Rader

Bioconjug Chem· October 2012

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Chemically programmed bispecific antibodies that recruit and activate T cells.
Huiting Cui, Joshua D Thomas, Terrence R Burke, Christoph Rader

J Biol Chem· August 2012

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Application of a water-soluble pyridyl disulfide amine linker for use in Cu-free click bioconjugation.
Joshua D Thomas, Terrence R Burke

Tetrahedron Lett· August 2011

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Soft alkyl ether prodrugs of a model phenolic drug: the effect of incorporation of ethyleneoxy groups on transdermal delivery.
Joshua Denver Thomas, Susruta Majumdar, Kenneth Berry Sloan

Molecules· October 2009

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Evaluation of alkyloxycarbonyloxymethyl (AOCOM) ethers as novel prodrugs of phenols for topical delivery: AOCOM prodrugs of acetaminophen.
Joshua D Thomas, Kenneth B Sloan

Int J Pharm· April 2009

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Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates.
Joshua D Thomas, Thomas Hofer, Christoph Rader, Terrence R Burke

Bioorg Med Chem Lett· November 2008

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An engineered selenocysteine defines a unique class of antibody derivatives.
Thomas Hofer, Joshua D Thomas, Terrence R Burke, Christoph Rader

Proc Natl Acad Sci U S A· August 2008

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In vitro evaluation of alkylcarbonyloxymethyl (ACOM) ethers as novel prodrugs of phenols for topical delivery: ACOM prodrugs of acetaminophen.
Joshua D Thomas, Kenneth B Sloan

Int J Pharm· January 2008

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Benzene-Free Synthesis of Phenol This research was supported by a grant awarded by the U.S. Department of Agriculture.
James M. Gibson, Phillip S. Thomas, Joshua D. Thomas, Jessica L. Barker, Sunil S. Chandran

Angew Chem Int Ed Engl· May 2001

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