Publications by authors named "Joshua W Modell"

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Bacteria exploit viral dormancy to establish CRISPR-Cas immunity.
Nicholas C Keith, Rhett A Snyder, Chad W Euler, Joshua W Modell

Cell Host Microbe· March 2025

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A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage.
Marie J Stoltzfus, Rachael E Workman, Nicholas C Keith, Joshua W Modell

Nat Microbiol· September 2024

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Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense.
Rachael E Workman, Marie J Stoltzfus, Nicholas C Keith, Chad W Euler, Joseph Bondy-Denomy, Joshua W Modell

Cell Rep· March 2024

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Prophage-like gene transfer agents promote Caulobacter crescentus survival and DNA repair during stationary phase.
Kevin Gozzi, Ngat T Tran, Joshua W Modell, Tung B K Le, Michael T Laub

PLoS Biol· November 2022

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Cleavage of viral DNA by restriction endonucleases stimulates the type II CRISPR-Cas immune response.
Pascal Maguin, Andrew Varble, Joshua W Modell, Luciano A Marraffini

Mol Cell· March 2022

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Viral recombination systems limit CRISPR-Cas targeting through the generation of escape mutations.
Amer A Hossain, Jon McGinn, Alexander J Meeske, Joshua W Modell, Luciano A Marraffini

Cell Host Microbe· October 2021

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A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression.
Rachael E Workman, Teja Pammi, Binh T K Nguyen, Leonardo W Graeff, Erika Smith, Joshua W Modell

Cell· February 2021

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Incomplete prophage tolerance by type III-A CRISPR-Cas systems reduces the fitness of lysogenic hosts.
Gregory W Goldberg, Elizabeth A McMillan, Andrew Varble, Joshua W Modell, Poulami Samai

Nat Commun· January 2018

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CRISPR-Cas systems exploit viral DNA injection to establish and maintain adaptive immunity.
Joshua W Modell, Wenyan Jiang, Luciano A Marraffini

Nature· April 2017

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Cas9 specifies functional viral targets during CRISPR-Cas adaptation.
Robert Heler, Poulami Samai, Joshua W Modell, Catherine Weiner, Gregory W Goldberg

Nature· March 2015

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A DNA damage-induced, SOS-independent checkpoint regulates cell division in Caulobacter crescentus.
Joshua W Modell, Tracy K Kambara, Barrett S Perchuk, Michael T Laub

PLoS Biol· October 2014

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A DNA damage checkpoint in Caulobacter crescentus inhibits cell division through a direct interaction with FtsW.
Joshua W Modell, Alexander C Hopkins, Michael T Laub

Genes Dev· June 2011

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Mitochondrial gradients and p38 activity in early sea urchin embryos.
Joshua W Modell, Cynthia A Bradham

Mol Reprod Dev· April 2011

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Chordin is required for neural but not axial development in sea urchin embryos.
Cynthia A Bradham, Catherine Oikonomou, Alexander Kühn, Amanda B Core, Joshua W Modell

Dev Biol· April 2009

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.
Justin Lamb, Emily D Crawford, David Peck, Joshua W Modell, Irene C Blat

Science· September 2006

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