Publications by authors named "Judith Simcox"

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Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice.
Michaela E Trautman, Cara L Green, Michael R MacArthur, Krittisak Chaiyakul, Yasmine H Alam, Judith A Simcox

Mol Metab· November 2025

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ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism.
Edrees H Rashan, Abigail K Bartlett, Daven B Khana, Jingying Zhang, Raghav Jain, Judith A Simcox

Nat Struct Mol Biol· September 2025

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Stearoyl-CoA Desaturases regulate stem and progenitor cell metabolism and function in response to nutrient abundance.
Kübra B Akkaya-Colak, Andrea R Keller, Maria H Festing, Khushboo Gupta, James Sledziona, Judith A Simcox

bioRxiv· September 2025

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Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis.
Kyle M Flickinger, Carlos A Mellado Fritz, Kimberly S Huggler, Gina M Wade, Gavin R Chang, Judith A Simcox

Nat Metab· June 2025

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PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease.
Kwamina Nyame, Jian Xiong, Hisham N Alsohybe, Arthur P H de Jong, Isabelle V Peña, Judith A Simcox

Nature· June 2025

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Stearoyl-CoA desaturase 1 deficiency drives saturated lipid accumulation and increases liver and plasma acylcarnitines.
Mugagga Kalyesubula, Helaina Von Bank, Jessica W Davidson, Maggie S Burhans, Madelaine M Becker, Judith Simcox

J Lipid Res· June 2025

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Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV.
Jessica W Davidson, Raghav Jain, Thomas Kizzar, Gisela Geoghegan, Daniel J Nesbitt, Judith A Simcox

Cell Metab· June 2025

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Dietary lipids are largely deposited in skin and rapidly affect insulating properties.
Nick Riley, Ildiko Kasza, Isabel D K Hermsmeyer, Michaela E Trautman, Greg Barrett-Wilt, Judith A Simcox

Nat Commun· May 2025

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Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by .
Jessica W Davidson, Raghav Jain, Thomas Kizzar, Gisela Geoghegan, Daniel J Nesbitt, Judith A Simcox

bioRxiv· February 2025

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PLA2G15 is a Lysosomal BMP Hydrolase and its Targeting Ameliorates Lysosomal Disease.
Kwamina Nyame, Jian Xiong, Hisham N Alsohybe, Arthur Ph de Jong, Isabelle V Peña, Judith A Simcox

bioRxiv· February 2025

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The role of ATP citrate lyase in myelin formation and maintenance.
Andrew Schneider, Seongsik Won, Eric A Armstrong, Aaron J Cooper, Amulya Suresh, Judith A Simcox

Glia· January 2025

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Phocaeicola vulgatus shapes the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile.
Jordy Evan Sulaiman, Jaron Thompson, Pak Lun Kevin Cheung, Yili Qian, Jericha Mill, Judith Simcox

Cell Host Microbe· January 2025

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Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging.
Chung-Yang Yeh, Lucas C S Chini, Jessica W Davidson, Gonzalo G Garcia, Meredith S Gallagher, Judith A Simcox

Nat Aging· December 2024

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Liver-specific deletion of Agpat5 protects against liquid sucrose-induced hyperinsulinemia and glucose intolerance.
Sylwia Michorowska, Kara R Vogel, Raghav Jain, Samantha L St Clair, Judith A Simcox

Biochem Biophys Res Commun· December 2024

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Systemic analysis shows that cold exposure modulates triglyceride accumulation and phospholipid distribution in mice.
Isabella James, Raghav Jain, Gina Wade, Philip C Stevenson, Albert Koulman, Judith Simcox

PLoS One· November 2024

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Dietary lipid is largely deposited in skin and rapidly affects insulating properties.
Nick Riley, Ildiko Kasza, Isabel D K Hermsmeyer, Michaela E Trautman, Greg Barrett-Wilt, Judith A Simcox

Res Sq· October 2024

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Neutral sphingomyelinase regulates mechanotransduction in human engineered cardiac tissues and mouse hearts.
Daniel G P Turner, Willem J De Lange, Yanlong Zhu, Christopher L Coe, Judith Simcox

J Physiol· September 2024

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Diabetes mellitus-Progress and opportunities in the evolving epidemic.
E Dale Abel, Anna L Gloyn, Carmella Evans-Molina, Joshua J Joseph, Shivani Misra, Judith Simcox

Cell· July 2024

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Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of .
Jordy Evan Sulaiman, Jaron Thompson, Pak Lun Kevin Cheung, Yili Qian, Jericha Mill, Judith Simcox

bioRxiv· July 2024

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Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer's disease.
Reji Babygirija, Michelle M Sonsalla, Jericha Mill, Isabella James, Jessica H Han, Judith Simcox

Nat Commun· June 2024

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Dietary isoleucine content defines the metabolic and molecular response to a Western diet.
Michaela E Trautman, Cara L Green, Michael R MacArthur, Krittisak Chaiyakul, Yasmine H Alam, Judith A Simcox

bioRxiv· June 2024

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Branching out beyond canonical brown adipocyte function.
Helaina Von Bank, Judith Simcox

Cell Metab· May 2024

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Membrane-bound -acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
Venkateshwari Varadharajan, Iyappan Ramachandiran, William J Massey, Raghav Jain, Rakhee Banerjee, Judith Simcox

Elife· April 2024

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ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism.
Edrees H Rashan, Abigail K Bartlett, Daven B Khana, Jingying Zhang, Raghav Jain, Judith A Simcox

bioRxiv· January 2024

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Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice.
Cara L Green, Michaela E Trautman, Krittisak Chaiyakul, Raghav Jain, Yasmine H Alam, Judith Simcox

Cell Metab· November 2023

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